Art. -Nr.: HY-N7015

Zerumbone

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Zerumbone is an orally active natural cyclic sesquiterpene and can be isolated from Zingiber zerumbet. Zerumbone has anti-proliferative, anti-inflammation, anti-cancer, anti-bacterial and anti-mutagenic activity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.74%
CAS. Nr.: 471-05-6
Formel: C₁₅H₂₂O
Molecular Weight:218.33

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Zerumbone Chemical Structure

CAS. Nr.: 471-05-6

Größe

Preis

Verfügbarkeit

Menge

Sample (0.1mg)

In-stock

(In Japan)

Apply Now

Angebot einholen Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability Angebot einholen Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability

Massenanfrage

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Caspase 3

Alle Caspase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	5.5 nM Compound: Zerumbone	Potentiation of PTX-induced anticancer activity in human DU145 cells assessed as reduction in PTX IC50 (Rvb = 13.5 nmol/L) Potentiation of PTX-induced anticancer activity in human DU145 cells assessed as reduction in PTX IC50 (Rvb = 13.5 nmol/L)	[PMID: 31336310]
DU-145	IC₅₀	6.9 μM Compound: Zerumbone	Cytotoxicity against human DU145 cells Cytotoxicity against human DU145 cells	[PMID: 31336310]
HeLa	IC₅₀	3.15 μg/mL Compound: 2, Zerumbone	Antiproliferative activity against human HeLa cells Antiproliferative activity against human HeLa cells	[PMID: 26459207]
HepG2	IC₅₀	13.34 μg/mL Compound: 2, Zerumbone	Antiproliferative activity against human HepG2 cells Antiproliferative activity against human HepG2 cells	[PMID: 26459207]
MCF7	IC₅₀	9.67 μg/mL Compound: 2, Zerumbone	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 26459207]
P338	IC₅₀	2.63 μg/mL Compound: 2, Zerumbone	Antiproliferative activity against mouse P338 cells Antiproliferative activity against mouse P338 cells	[PMID: 26459207]
PANC-1	IC₅₀	0.91 μM Compound: 130	Inhibition of Gli2-mediated transcription expressed in human PANC1 cells Inhibition of Gli2-mediated transcription expressed in human PANC1 cells	[PMID: 19309080]
PANC-1	IC₅₀	7.1 μM Compound: 130	Inhibition of Gli1-mediated transcription expressed in human PANC1 cells Inhibition of Gli1-mediated transcription expressed in human PANC1 cells	[PMID: 19309080]
PC-3	IC₅₀	9.1 μM Compound: Zerumbone	Cytotoxicity against human PC3 cells Cytotoxicity against human PC3 cells	[PMID: 31336310]
RAW264.7	IC₅₀	13.6 μM Compound: 11	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by Griess reagent based assay Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by Griess reagent based assay	[PMID: 30024153]
SW480	IC₅₀	3.15 μg/mL Compound: 2, Zerumbone	Antiproliferative activity against human SW480 cells Antiproliferative activity against human SW480 cells	[PMID: 26459207]

In Vitro

Zerumbone (20.3/24.3/27.7 μM, 72 h) exert antiproliferative effects toward HeLa, Coav-3, and MCF-7 cells^[1].
Zerumbone (20.3 μM, 72 h) has an apoptogenic effect on HeLa cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HeLa, Coav-3, and MCF-7
Concentration:

20.3 μM for HeLa, 24.3 μM for Coav-3, 27.7 μM for MCF-7
Incubation Time:

72 h
Result:

Showed IC₅₀ values of 20.30 ± 1.1, 24.30 ± 0.9 and 27.7 ± 1.2 μM for HeLa, Coav-3, and MCF-7.

Apoptosis Analysis^[1]

Cell Line:

HeLa
Concentration:

20.3 μM
Incubation Time:

72 h
Result:

Significantly stimulated caspase-3.
Triggered morphological features that relates to apoptosis in a time-dependent manner.

In Vivo

Zerumbone (5-100 mg/kg, Intraperitoneal injection, single dose/once a day for 7 consecutive days) has anti-inflammatory effect in acute exudative/chronic proliferative models of inflammation in mice^[2].
Zerumbone (100-500 ppm, Oral, supplemented in daily diet for 17 weeks) has chemopreventive effect on AOM (HY-111375)/DSS-induced colon carcinogenesis in mice^[3].
Zerumbone (100-500 ppm, Oral, supplemented in daily diet for 21 weeks) has chemopreventive effect on NNK (HY-126477)-induced lung carcinogenesis in mice.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Carrageenan (HY-125474)-induced mice paw edema/Cotton pellet-induced granuloma mice^[2]
Dosage:

5 mg/kg, 10 mg/kg, 50 mg/kg, 100 mg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Significantly produced dose-dependent inhibition of paw oedema induced by carrageenan in mice with inhibition of 33.3, 66.7, 83.3, and 83.3%, respectively.
Produced a significant reduction on the granulomatous tissue formation on implanted cotton pellets with inhibition of 34.8, 60.6 and 70.6%, respectively.

Chemical Information

CAS. Nr. 471-05-6
Appearance Solid
Molecular Weight 218.33
Formel C₁₅H₂₂O
Color White to light yellow
SMILES

C/C1=C\CC/C(C)=C/CC(C)(C)/C=C/C1=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

All Cell Proliferation/Viability AssayCell Migration/Invasion AssayWBIFRT-PCR

Sort by:

Journal Impact Factor

Naunyn Schmiedebergs Arch Pharmacol

Zerumbone alleviated bleomycin-induced pulmonary fibrosis in mice via SIRT1/Nrf2 pathway. [Abstract]

2024 Nov;397(11):8979-8992. PMID: 38874804

Zerumbone purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov;397(11):8979-8992. [Abstract]

Cell viability of MRC-5 cells treated with various concentrations of Zerumbone (Zerum) (0, 10, 20, 40, 80, 160 μM) as determined by CCK-8 assay.

Zerumbone purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov;397(11):8979-8992. [Abstract]

Migration of MRC-5 cells assessed by wound healing assay treated with Zerumbone (Zerum) (20, 40 μM).

Zerumbone purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov;397(11):8979-8992. [Abstract]

Protein expression of Collagen I, α-SMA, Fibronectin, p-SMAD2/3 and SMAD2/3 in MRC-5 cells treated with Zerumbone (Zerum) (20, 40 μM).

Zerumbone purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov;397(11):8979-8992. [Abstract]

Representative immunofuorescence staining images for Collagen I, α-SMA, and F-actin proteins treated with Zerumbone (Zerum) (20, 40 μM).

Zerumbone purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov;397(11):8979-8992. [Abstract]

mRNA expression levels of Collagen I and α-SMA treated with Zerumbone (Zerum) (20, 40 μM).
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 125 mg/mL (572.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.5802 mL

22.9011 mL

45.8022 mL

5 mM

0.9160 mL

4.5802 mL

9.1604 mL

10 mM

0.4580 mL

2.2901 mL

4.5802 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (9.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.08 mg/mL (9.53 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (9.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Portuguese - PT (537 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Abdel Wahab S I, et al. In vitro ultramorphological assessment of apoptosis induced by zerumbone on (HeLa) [J]. BioMed Research International, 2009, 2009. [Content Brief]

[2]. Sulaiman M R, et al. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice [J]. Fitoterapia, 2010, 81(7): 855-858. [Content Brief]

[3]. Kim M, et al. Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice [J]. International journal of cancer, 2009, 124(2): 264-271. [Content Brief]

[4]. Kumar S C S, et al. Antibacterial and antimutagenic activities of novel zerumbone analogues [J]. Food Chemistry, 2013, 141(2): 1097-1103. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.5802 mL	22.9011 mL	45.8022 mL	114.5056 mL
	5 mM	0.9160 mL	4.5802 mL	9.1604 mL	22.9011 mL
	10 mM	0.4580 mL	2.2901 mL	4.5802 mL	11.4506 mL
	15 mM	0.3053 mL	1.5267 mL	3.0535 mL	7.6337 mL
	20 mM	0.2290 mL	1.1451 mL	2.2901 mL	5.7253 mL
	25 mM	0.1832 mL	0.9160 mL	1.8321 mL	4.5802 mL
	30 mM	0.1527 mL	0.7634 mL	1.5267 mL	3.8169 mL
	40 mM	0.1145 mL	0.5725 mL	1.1451 mL	2.8626 mL
	50 mM	0.0916 mL	0.4580 mL	0.9160 mL	2.2901 mL
	60 mM	0.0763 mL	0.3817 mL	0.7634 mL	1.9084 mL
	80 mM	0.0573 mL	0.2863 mL	0.5725 mL	1.4313 mL
	100 mM	0.0458 mL	0.2290 mL	0.4580 mL	1.1451 mL

Keywords

Zerumbone

2 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Zerumbone

Anti-Infection Compound Library

Apoptosis Compound Library

Natural Product Library

Anti-Cancer Compound Library

Macrocyclic Compound Library

Antibacterial Compound Library

Medicine Food Homology Compound Library

Terpenoids Library

Pyroptosis Compound Library

Orally Active Compound Library

Traditional Chinese Medicine Active Compound Library

Food-Sourced Compound Library

Anti-Cancer Natural Product Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Cell Death Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Zerumbone

Alle Caspase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Zerumbone Related Classifications

Art. -Nr.: HY-N7015