M464
Based on 1 Customer Validation
M464, a non-steroidal anti-inflammatory compound, is a potent and orally active NLRP3 inflammasome inhibitor. M464 inhibits pyroptosis and hinders the activation of downstream Caspase-1 expression and the release of IL-1β by impeding ASC oligomerisation and curtailing ROS production. M464 exhibits protective effects against acute lung and liver injury in mice. M464 can be used for the research of NLRP3-related inflammatory diseases.
For research use only. We do not sell to patients.
- Purity: 99.58%
- Formula: C23H28O4S3
- Molecular Weight:464.66
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Differentiation Inducing Compound Library
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Oxygen Sensing Compound Library
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Pyroptosis Compound Library
HY-L059
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Angiogenesis-Related Compound Library
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Pain-Related Compound Library
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Protease Inhibitor Library
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Membrane Receptor-targeted Compound Library
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Autoimmune Disease Compound Library
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Cytokine Inhibitors Library
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Cell Death Library
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Inflammasomes related Compound Library
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Multi-Target Compound Library
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Radioprotector Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Bioactive Compound Library
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
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High-Throughput Bioactive Compound Library
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Pattern Recognition Receptors Library
HY-L237
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Lactylation Compound Library
HY-L249
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Apoptosis Compound Library
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Immunology/Inflammation Compound Library
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Metabolism/Protease Compound Library
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NF-κB Signaling Compound Library
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Anti-Aging Compound Library
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All Caspase Isoforms
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Biological Activity
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NLRP3 inflammasome |
M464 (3-12 μM) inhibits the expression of marker proteins associated with NLRP3 inflammasome activation (IL-1β and Caspase-1), and restrains the production of intracellular ROS and the formation of ASC oligomers in J774A.1 and THP-1 cells[1].
M464 (3-12 μM; 1 h) inhibits pyroptosis in macrophages triggered by the NLRP3 inflammasome stimulator in J774A.1 and THP-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
M464 (15, 30, 60 mg/kg; i.g.; single dose; 1 hour before LPS injection) mitigates LPS and D-GalN-induced acute liver injury in mice by inhibiting NLRP3 inflammasome activation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male KM mice (42-56 days old) intraperitoneally injected with LPS (10 mg/kg)[1]
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Dosage:15, 30, 60 mg/kg
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Administration:i.g.; single dose; 1 hour before LPS injection
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Result:Dose-dependently reduced the pathological scores of lung injury.
Significantly improved the lung tissue damage in mice.
Inhibited the lung wet/dry (W/D) weight ratio and significantly improved pulmonary edema in mice.
Significantly reduced the levels of mature IL-1β and Caspase-1.
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Animal Model:Male KM mice (42-56 days old) intraperitoneally injected with LPS (50 μg/kg) and D-GalN (800 mg/kg)[1]
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Dosage:15, 30, 60 mg/kg
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Administration:i.g.; 1 hour before LPS injection
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Result:Reversed the LPS and D-GalN induced increase of the liver-to-body weight ratio.
Markedly attenuated LPS/D-GalN-induced liver injury in mice.
Exhibited dose-dependent suppression of serum levels of AST and ALT.
Effectively suppressed the mature IL-1β release and Caspase-1 production in a dose-dependent manner.
Effectively reversed the LPS/D-GalN-induced reduction in SOD content and increase in MDA level.
Chemical Information
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Appearance Solid
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Molecular Weight 464.66
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Formula C23H28O4S3
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Color Orange to red
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SMILES
CC1CC(OC(CCC(OC2=CC=C(C3=CC(SS3)=S)C=C2)=O)=O)C(C(C)C)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
M464 Related Classifications
HY-179494 Related Classifications
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