CDK4-IN-7
CDK4-IN-7 is a CDK4 inhibitor with an IC50 of 26 nM. CDK4-IN-7 shows selectivity for CDK1, with an IC50 of 4.2262 μM. CDK4-IN-7 can be used in cancer research.
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- CAS No.: 3113087-01-4
- Formule: C20H28F2N6O2S
- Masse moléculaire:454.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
CDK4 26 nM (IC50) |
CDK1 4.2262 μM (IC50) |
In Vitro
CDK4-IN-7 (Compound 5) potently inhibits CDK4 with an IC50 of 26 nM and shows 162.5-fold selectivity for CDK4 over CDK1 in a biochemical kinase assay measuring retinoblastoma protein Ser780 phosphorylation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3113087-01-4
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Masse moléculaire 454.54
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Formule C20H28F2N6O2S
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SMILES
CC1=CC2=CN=C(N[C@H]3[C@H](F)CN(S(C4CC4)(=O)=O)CC3)N=C2N1[C@@H]5CCNC[C@@H]5F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK4-IN-7 Related Classifications
HY-184444 Related Classifications
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