CCL2 - C-C motif chemokine ligand 2 Gene
Also Known as HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30
Species: Homo sapiens
About CCL2
This gene has 3 transcripts (splice variants), 118 orthologues, 25 paralogues and is associated with 4 phenotypes. Ubiquitous expression in gall bladder (RPKM 117.6), appendix (RPKM 92.3) and 23 other tissues.
Summary
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Infection. [provided by RefSeq, Aug 2020]
CCL2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_002982.4 | NP_002973.1 | C-C motif chemokine 2 precursor |
CCL2 Protein Structure
IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (30 - 90)
- 0
- 99 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
C-C motif chemokine 2 |
|
CCL2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
CCL2 | P13500 | CCL8 | Homo sapiens | P80075 | 28381538 | |
|
Intra
|
CCL2 | P13500 | RNF4 | Homo sapiens | P78317 | 32296183 | |
|
Intra
|
CCL2 | P13500 | RNF4 | Homo sapiens | P78317 | 32296183 | |
|
Intra
|
CCL2 | P13500 | RNF4 | Homo sapiens | P78317 | 32296183 | |
|
Intra
|
CCL2 | P13500 | PF4 | Homo sapiens | P02776 | 28381538 | |
|
Intra
|
CCL2 | P13500 | PF4 | Homo sapiens | P02776 | 28381538 | |
|
Intra
|
CCL2 | P13500 | CCL5 | Homo sapiens | P13501 | 28381538 | |
|
Intra
|
CCL2 | P13500 | CCL5 | Homo sapiens | P13501 | 28381538 | |
|
Intra
|
CCL2 | P13500 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
CCL2 | P13500 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
CCL2 | P13500 | TMX2 | Homo sapiens | Q9Y320 | 32296183 |
Recombinant CCL2 Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P7237 | MCP-1/CCL2 Protein, Human | P13500 (Q24-T99) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78173 | MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) | P13500 (Q24-T99) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78488 | MCP-1/CCL2 Protein, Human (HEK293, His-Avi) | P13500 (Q24-T99) | ≥ 90%, as determined by Bis-Tris PAGE. |
| HY-P700034AF | Animal-Free MCP-1/CCL2 Protein, Human (His) | P13500 (Q24-T99) | ≥ 95%, as determined by reducing SDS-PAGE. |
CCL2 Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P81171 | MCP1 Antibody | WB, ELISA, IHC-P, IHC-F, FC, ICC/IF | Human, Rat |
| HY-P84082 | MCP1 Antibody (YA3779) | WB, IHC-P, ICC/IF, FC, ELISA, ELISA | Human, Mouse, Rat, Monkey |
| HY-P84082A | MCP1 Antibody (YA3779)(PBS only) | WB, IHC-P, ICC/IF, FC, ELISA, ELISA | Human, Mouse, Rat, Monkey |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Neural Tube Defects |
|
|
| Human Immunodeficiency Virus Type 1 |
|
|
| Severe Acute Respiratory Syndrome |
|
|
| Proliferative Glomerulonephritis |
|
|
| Arteriosclerosis |
|
|
| Peritonitis |
|
|
| Pertussis |
|
|
| Retinal Vasculitis |
|
|
| Mesangial Proliferative Glomerulonephritis |
|
|
| Anthracosis |
|
|
| Fatty Liver Disease |
|
|
| Covid-19 |
|
|
| Renal Fibrosis |
|
|
| Pelvic Inflammatory Disease |
|
|
| Kawasaki Disease |
|
|
| Uveitis |
|
|
| Diabetic Angiopathy |
|
|
| Pulmonary Alveolar Proteinosis |
|
|
| Mast-Cell Leukemia |
|
|
| Rheumatoid Arthritis |
|
|
| Radiculopathy |
|
|
| Encephalitis |
|
|
| Glomerulonephritis |
|
|
| Retinal Vein Occlusion |
|
|
| Interstitial Lung Disease |
|
|
| Lung Disease |
|
|
| Pulmonary Sarcoidosis |
|
|
| Erdheim-Chester Disease |
|
|
| Pulmonary Fibrosis |
|
|
| Viral Meningitis |
|
|
| Arthritis |
|
|
| Alcoholic Hepatitis |
|
|
| Pneumonia |
|
|
| Hyperhomocysteinemia |
|
|
| Pleurisy |
|
|
| Pneumoconiosis |
|
|
| Atherosclerosis Susceptibility |
|
|
| Schnitzler Syndrome |
|
|
| Vascular Disease |
|
|
| Nephrosclerosis |
|
|
| Vasculitis |
|
|
| Chronic Eosinophilic Pneumonia |
|
|
| Bacteriuria |
|
|
| Pleural Tuberculosis |
|
|
| Scleritis |
|
|
| Lipoid Nephrosis |
|
|
| Liver Disease |
|
|
| Psoriasis |
|
|
| Trypanosomiasis |
|
|
| Pyelonephritis |
|
|
| Endometriosis |
|
|
| Microvascular Complications Of Diabetes 1 |
|
|
| Extrinsic Allergic Alveolitis |
|
|
| Chorioamnionitis |
|
|
| Meningitis |
|
|
| Bacterial Meningitis |
|
|
| Systemic Lupus Erythematosus |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Leptospirosis |
|
|
| Carpal Tunnel Syndrome |
|
|
| Conjunctivitis |
|
|
| Iga Glomerulonephritis |
|
|
| Pustular Psoriasis |
|
|
| Yellow Fever |
|
|
| Bronchiolitis |
|
|
| Hepatopulmonary Syndrome |
|
|
| Hydronephrosis |
|
|
| Ileus |
|
|
| Proteasome-Associated Autoinflammatory Syndrome 1 |
|
|
| Silicosis |
|
|
| Interstitial Lung Disease 2 |
|
|
| Eosinophilic Pneumonia |
|
|
| Vitreoretinopathy, Neovascular Inflammatory |
|
|
| Periodontitis |
|
|
| Q Fever |
|
|
| Cardiovascular System Disease |
|
|
| Aggressive Periodontitis |
|
|
| Relapsing-Remitting Multiple Sclerosis |
|
|
| Kidney Disease |
|
|
| Urolithiasis |
|
|
| Chagas Disease |
|
|
| Peripheral Vascular Disease |
|
|
| Appendicitis |
|
|
| Central Nervous System Disease |
|
|
| Disseminated Intravascular Coagulation |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Periapical Granuloma |
|
|
| Retinal Detachment |
|
|
| Neuritis |
|
|
| Glucose Intolerance |
|
|
| Multiple Sclerosis |
|
|
| Sleep Apnea |
|
|
| Sarcoidosis 1 |
|
|
| Fibromyalgia |
|
|
| Gingivitis |
|
|
| Obstructive Nephropathy |
|
|
| Schistosomiasis |
|
|
| Leishmaniasis |
|
|
| Malaria |
|
|
| Pulmonary Tuberculosis |
|
|
| Osteomyelitis |
|
|
| Myocarditis |
|
|
| Demyelinating Disease |
|
|
| Synovitis |
|
|
| Cystitis |
|
|
| Chikungunya |
|
|
| Aortic Aneurysm, Familial Abdominal, 1 |
|
|
| Chlamydia |
|
|
| Acute Pancreatitis |
|
|
| Aortic Aneurysm |
|
|
| Monocytic Leukemia |
|
|
| Takayasu Arteritis |
|
|
| Systemic Scleroderma |
|
|
| Autoimmune Disease |
|
|
| Lymphangioleiomyomatosis |
|
|
| Pulmonary Disease, Chronic Obstructive |
|
|
| Pulmonary Hypertension |
|
|
| Macular Retinal Edema |
|
|
| Gastroesophageal Reflux |
|
|
| Pancreatic Cancer |
|
|
| Bacterial Infectious Disease |
|
|
| Varicose Veins |
|
|
| Membranous Nephropathy |
|
|
| Asthma |
|
|
| Otitis Media |
|
|
| Aortic Atherosclerosis |
|
|
| Diabetic Macular Edema |
|
|
| Inflammatory Bowel Disease |
|
|
| Palladium Allergic Contact Dermatitis |
|
|
| Macular Degeneration, Age-Related, 1 |
|
|
| Coronavirus Infectious Disease |
|
|
| Severe Covid-19 |
|
|
| Crescentic Glomerulonephritis |
|
|
| Ureteral Disease |
|
|
| Viral Pneumonia |
|
|
| Acute Proliferative Glomerulonephritis |
|
|
| Lipid Metabolism Disorder |
|
|
| Critical Covid-19 |
|
|
| Retinal Vascular Occlusion |
|
|
| Leukostasis |
|
|
| Danubian Endemic Familial Nephropathy |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Viral Infectious Disease |
|
|
| Central Retinal Vein Occlusion |
|
|
| Immune Deficiency Disease |
|
|
| Autoimmune Myocarditis |
|
|
| Viral Encephalitis |
|
|
| Heart Disease |
|
|
| Bacterial Sepsis |
|
|
| Endometrial Stromal Sarcoma |
|
|
| Fuchs' Heterochromic Uveitis |
|
|
| Myelofibrosis |
|
|
| Extrinsic Cardiomyopathy |
|
|
| Narcolepsy |
|
|
| Urinary Tract Obstruction |
|
|
| Temporal Arteritis |
|
|
| Dermatitis, Atopic |
|
|
| Neovascular Glaucoma |
|
|
| Retinal Artery Occlusion |
|
|
| Myocardial Infarction |
|
|
| Tenosynovial Giant Cell Tumor |
|
|
| Non-Alcoholic Steatohepatitis |
|
|
| Hypertension, Essential |
|
|
| Thrombocytopenia |
|
|
| Retinal Ischemia |
|
|
| Long Covid |
|
|
| Diabetes Mellitus |
|
|
| Retinal Vascular Disease |
|
|
| Autoimmune Disease Of Musculoskeletal System |
|
|
| Cataract |
|
|
| Orchitis |
|
|
| Degeneration Of Macula And Posterior Pole |
|
|
| Middle East Respiratory Syndrome |
|
|
| Bacterial Pneumonia |
|
|
| Background Diabetic Retinopathy |
|
|
| Vitreous Disease |
|
|
| Bone Inflammation Disease |
|
|
| Macular Holes |
|
|
| Leukemia, Acute Monocytic |
|
|
| Autoimmune Disease Of Central Nervous System |
|
|
| Severe Nonproliferative Diabetic Retinopathy |
|
|
| Blood Group, Globoside System |
|
|
| Bronchial Disease |
|
|
| Nephrotic Syndrome |
|
|
| Baritosis |
|
|
| Leptin Deficiency Or Dysfunction |
|
|
| Vein Disease |
|
|
| Autoimmune Disease Of Eyes, Ear, Nose And Throat |
|
|
| Primary Bacterial Infectious Disease |
|
|
| Acute Kidney Tubular Necrosis |
|
|
| Kuhnt-Junius Degeneration |
|
|
| Peripheral Artery Disease |
|
|
| Overnutrition |
|
|
| Acquired Metabolic Disease |
|
|
| Bronchopneumonia |
|
|
| Autoimmune Disease Of Cardiovascular System |
|
|
| Avian Influenza |
|
|
| Conjunctival Disease |
|
|
| Osteoporosis |
|
|
| Retinitis Pigmentosa 90 |
|
|
| Bipolar Disorder |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Uveal Disease |
|
|
| Lung Cancer |
|
|
| Ebola Hemorrhagic Fever |
|
|
| Lipid Storage Disease |
|
|
| Cerebral Artery Occlusion |
|
|
| Hemophagocytic Lymphohistiocytosis |
|
|
| Commensal Bacterial Infectious Disease |
|
|
| Arteries, Anomalies Of |
|
|
| Respiratory Failure |
|
|
| Cystic Fibrosis |
|
|
| Autoimmune Disease Of Skin And Connective Tissue |
|
|
| Leukocyte Disease |
|
|
| Microphthalmia, Isolated 1 |
|
|
| Lens Disease |
|
|
| Toxic Encephalopathy |
|
|
| Autoimmune Disease Of Gastrointestinal Tract |
|
|
| Glucose Metabolism Disease |
|
|
| Carbohydrate Metabolic Disorder |
|
|
| Ovarian Cancer |
|
|
| Integumentary System Disease |
|
|
| Gastric Cancer |
|
|
| Prostate Cancer |
|
|
| Exudative Vitreoretinopathy 1 |
|
|
| Colorectal Cancer |
|
|
| Crohn'S Disease |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Cervix Carcinoma |
|
|
| Leprosy 3 |
|
|
| Preterm Premature Rupture Of The Membranes |
|
|
| Breast Cancer |
|
|
| Schizophrenia |
|
|
| Behcet Syndrome |
|
|
| Peripheral Nervous System Disease |
|
|
| Cholangitis, Primary Sclerosing |
|
|
| Eye Disease |
|
|
| Breast Adenocarcinoma |
|
|
| Skin Disease |
|
|
| Connective Tissue Disease |
|
|
| Autosomal Dominant Polycystic Kidney Disease |
|
|
| Nervous System Disease |
|
|
| Primary Biliary Cholangitis |
|
|
| Aortic Aneurysm, Familial Thoracic 1 |
|
|
| Celiac Disease 1 |
|
|
| Polycystic Kidney Disease |
|
|
| Migraine With Or Without Aura 1 |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Dilated Cardiomyopathy |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Retinitis Pigmentosa |
|
|
| Fundus Dystrophy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | CCL2 | MGD | MGI:98259 |
| Macaca mulatta | CCL2 | VGNC | VGNC:70698 |
| Canis familiaris | CCL2 | VGNC | VGNC:52021 |
| Rattus norvegicus | CCL2 | RGD | RGD:3645 |
| Others | CCL2 | NCBI |