HS-36
HS-36 is a highly selective and orally active dual inhibitor of CDK4 and CDK9 with IC50 values of 18.9 and 4.2 nM respectively. HS-36 exhibits nanomolar-level potent activity against various cancer cells, inducing G0/G1 phase arrest and promoting cell apoptosis. HS-36 efficiently inhibits tumor growth in a mouse model of MV-4-11 tumors. HS-36 can be used for the study of acute myeloid leukemia.
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- Formule: C24H25N3O5
- Masse moléculaire:435.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CDK9 4.2 nM (IC50) |
CDK4 18.9 nM (IC50) |
CDK2 197.3 nM (IC50) |
CDK6 125.5 nM (IC50) |
CDK9 216.9 nM (IC50) |
CDK1 > 500 nM (IC50) |
CDK7 > 500 nM (IC50) |
CDK12 > 500 nM (IC50) |
Chemical Information
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Masse moléculaire 435.47
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Formule C24H25N3O5
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SMILES
O=C1C2=C(C=C3C(N(C(O3)=O)[C@H](C)CC)=C2OC(C4=CC=C(C=C4)N5CCNCC5)=C1)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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