Zerumbone
Based on 2 publication(s) in Google Scholar
Zerumbone is an orally active natural cyclic sesquiterpene and can be isolated from Zingiber zerumbet. Zerumbone has anti-proliferative, anti-inflammation, anti-cancer, anti-bacterial and anti-mutagenic activity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.74%
- CAS No.: 471-05-6
- Formule: C15H22O
- Masse moléculaire:218.33
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) Zerumbone
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Migration/Invasion Assay
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WB
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IF
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RT-PCR
Voir tous les produits spécifiques à Isoform Caspase
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Activité biologique
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Caspase 3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
5.5 nM
Compound: Zerumbone
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Potentiation of PTX-induced anticancer activity in human DU145 cells assessed as reduction in PTX IC50 (Rvb = 13.5 nmol/L)
Potentiation of PTX-induced anticancer activity in human DU145 cells assessed as reduction in PTX IC50 (Rvb = 13.5 nmol/L)
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[PMID: 31336310] |
| DU-145 | IC50 |
6.9 μM
Compound: Zerumbone
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Cytotoxicity against human DU145 cells
Cytotoxicity against human DU145 cells
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[PMID: 31336310] |
| HeLa | IC50 |
3.15 μg/mL
Compound: 2, Zerumbone
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Antiproliferative activity against human HeLa cells
Antiproliferative activity against human HeLa cells
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[PMID: 26459207] |
| HepG2 | IC50 |
13.34 μg/mL
Compound: 2, Zerumbone
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Antiproliferative activity against human HepG2 cells
Antiproliferative activity against human HepG2 cells
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[PMID: 26459207] |
| MCF7 | IC50 |
9.67 μg/mL
Compound: 2, Zerumbone
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Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
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[PMID: 26459207] |
| P338 | IC50 |
2.63 μg/mL
Compound: 2, Zerumbone
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Antiproliferative activity against mouse P338 cells
Antiproliferative activity against mouse P338 cells
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[PMID: 26459207] |
| PANC-1 | IC50 |
0.91 μM
Compound: 130
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Inhibition of Gli2-mediated transcription expressed in human PANC1 cells
Inhibition of Gli2-mediated transcription expressed in human PANC1 cells
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[PMID: 19309080] |
| PANC-1 | IC50 |
7.1 μM
Compound: 130
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Inhibition of Gli1-mediated transcription expressed in human PANC1 cells
Inhibition of Gli1-mediated transcription expressed in human PANC1 cells
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[PMID: 19309080] |
| PC-3 | IC50 |
9.1 μM
Compound: Zerumbone
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Cytotoxicity against human PC3 cells
Cytotoxicity against human PC3 cells
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[PMID: 31336310] |
| RAW264.7 | IC50 |
13.6 μM
Compound: 11
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Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
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[PMID: 30024153] |
| SW480 | IC50 |
3.15 μg/mL
Compound: 2, Zerumbone
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Antiproliferative activity against human SW480 cells
Antiproliferative activity against human SW480 cells
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[PMID: 26459207] |
Zerumbone (20.3/24.3/27.7 μM, 72 h) exert antiproliferative effects toward HeLa, Coav-3, and MCF-7 cells[1].
Zerumbone (20.3 μM, 72 h) has an apoptogenic effect on HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa, Coav-3, and MCF-7
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Concentration:20.3 μM for HeLa, 24.3 μM for Coav-3, 27.7 μM for MCF-7
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Incubation Time:72 h
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Result:Showed IC50 values of 20.30 ± 1.1, 24.30 ± 0.9 and 27.7 ± 1.2 μM for HeLa, Coav-3, and MCF-7.
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Cell Line:HeLa
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Concentration:20.3 μM
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Incubation Time:72 h
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Result:Significantly stimulated caspase-3.
Triggered morphological features that relates to apoptosis in a time-dependent manner.
Zerumbone (100-500 ppm, Oral, supplemented in daily diet for 17 weeks) has chemopreventive effect on AOM (HY-111375)/DSS-induced colon carcinogenesis in mice[3].
Zerumbone (100-500 ppm, Oral, supplemented in daily diet for 21 weeks) has chemopreventive effect on NNK (HY-126477)-induced lung carcinogenesis in mice.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Carrageenan (HY-125474)-induced mice paw edema/Cotton pellet-induced granuloma mice[2]
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Dosage:5 mg/kg, 10 mg/kg, 50 mg/kg, 100 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Significantly produced dose-dependent inhibition of paw oedema induced by carrageenan in mice with inhibition of 33.3, 66.7, 83.3, and 83.3%, respectively.
Produced a significant reduction on the granulomatous tissue formation on implanted cotton pellets with inhibition of 34.8, 60.6 and 70.6%, respectively.
Chemical Information
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CAS No. 471-05-6
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Appearance Solid
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Masse moléculaire 218.33
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Formule C15H22O
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Color White to light yellow
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SMILES
C/C1=C\CC/C(C)=C/CC(C)(C)/C=C/C1=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Naunyn Schmiedebergs Arch Pharmacol
Zerumbone alleviated bleomycin-induced pulmonary fibrosis in mice via SIRT1/Nrf2 pathway. [Abstract]2024 Nov;397(11):8979-8992. PMID: 38874804
Zerumbone purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov;397(11):8979-8992. [Abstract]
Cell viability of MRC-5 cells treated with various concentrations of Zerumbone (Zerum) (0, 10, 20, 40, 80, 160 μM) as determined by CCK-8 assay.
Zerumbone purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov;397(11):8979-8992. [Abstract]
Migration of MRC-5 cells assessed by wound healing assay treated with Zerumbone (Zerum) (20, 40 μM).
Zerumbone purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov;397(11):8979-8992. [Abstract]
Protein expression of Collagen I, α-SMA, Fibronectin, p-SMAD2/3 and SMAD2/3 in MRC-5 cells treated with Zerumbone (Zerum) (20, 40 μM).
Zerumbone purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov;397(11):8979-8992. [Abstract]
Representative immunofuorescence staining images for Collagen I, α-SMA, and F-actin proteins treated with Zerumbone (Zerum) (20, 40 μM).
Zerumbone purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov;397(11):8979-8992. [Abstract]
mRNA expression levels of Collagen I and α-SMA treated with Zerumbone (Zerum) (20, 40 μM).
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Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607
Solvant et solubilité
DMSO : ≥ 125 mg/mL (572.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (9.53 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.08 mg/mL (9.53 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (284 KB)
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SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Korean - KR (537 KB)
- Portuguese - PT (537 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Abdel Wahab S I, et al. In vitro ultramorphological assessment of apoptosis induced by zerumbone on (HeLa) [J]. BioMed Research International, 2009, 2009. [Content Brief]
[2]. Sulaiman M R, et al. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice [J]. Fitoterapia, 2010, 81(7): 855-858. [Content Brief]
[3]. Kim M, et al. Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice [J]. International journal of cancer, 2009, 124(2): 264-271. [Content Brief]
[4]. Kumar S C S, et al. Antibacterial and antimutagenic activities of novel zerumbone analogues [J]. Food Chemistry, 2013, 141(2): 1097-1103. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5802 mL | 22.9011 mL | 45.8022 mL | 114.5056 mL |
| 5 mM | 0.9160 mL | 4.5802 mL | 9.1604 mL | 22.9011 mL | |
| 10 mM | 0.4580 mL | 2.2901 mL | 4.5802 mL | 11.4506 mL | |
| 15 mM | 0.3053 mL | 1.5267 mL | 3.0535 mL | 7.6337 mL | |
| 20 mM | 0.2290 mL | 1.1451 mL | 2.2901 mL | 5.7253 mL | |
| 25 mM | 0.1832 mL | 0.9160 mL | 1.8321 mL | 4.5802 mL | |
| 30 mM | 0.1527 mL | 0.7634 mL | 1.5267 mL | 3.8169 mL | |
| 40 mM | 0.1145 mL | 0.5725 mL | 1.1451 mL | 2.8626 mL | |
| 50 mM | 0.0916 mL | 0.4580 mL | 0.9160 mL | 2.2901 mL | |
| 60 mM | 0.0763 mL | 0.3817 mL | 0.7634 mL | 1.9084 mL | |
| 80 mM | 0.0573 mL | 0.2863 mL | 0.5725 mL | 1.4313 mL | |
| 100 mM | 0.0458 mL | 0.2290 mL | 0.4580 mL | 1.1451 mL |
Zerumbone Related Classifications
HY-N7015 Related Classifications
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