Art. -Nr.: HY-N1463

Luteolin 7-O-glucuronide

(Synonyms: Luteolin 7-glucuronide)

3 Cited Publications

Kundenbewertung

Based on 3 publication(s) in Google Scholar

Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively.

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Reinheit: 99.98%
CAS. Nr.: 29741-10-4
Formel: C₂₁H₁₈O₁₂
Molecular Weight:462.36

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Luteolin 7-O-glucuronide Chemical Structure

CAS. Nr.: 29741-10-4

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively^[1].

IC₅₀ & Target

MMP-1

17.63 μM (IC₅₀)

MMP-3

7.99 μM (IC₅₀)

MMP-8

11.42 μM (IC₅₀)

MMP-9

12.85 μM (IC₅₀)

MMP13

0.03 μM (IC₅₀)

Alle MMP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	CC₅₀	>100 μM Compound: 21	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 33667099]
RAW264.7	IC₅₀	>100 μM Compound: 21	Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay	[PMID: 33667099]

In Vitro

Luteolin 7-O-glucuronide (0-50 μM, 2 h) inhibits NO production and mRNA expression of inflammatory mediators (COX-2, IL-6, IL-1β, and TNF-α) in LPS-stimulated RAW 264.7 macrophages^[2].
Luteolin 7-O-glucuronide (0-50 μM, 2 h) inhibits NF-κB, p38, and JNK activation in LPS-stimulated RAW 264.7 macrophages^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

LPS-stimulated RAW 264.7 macrophages
Concentration:

0-50 μM
Incubation Time:

2 h
Result:

Inhibited phosphorylation and degradation of IκB.
Inhibited phosphorylation of p38 and JNK.

In Vivo

Luteolin 7-O-glucuronide (0.3-3 mg/kg, p.o., once daily for 5 days) improves depression-like and stress coping behaviors in the tail suspension test and forced swimming test in a mouse sleep deprivation model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

mouse sleep deprivation model^[3]
Dosage:

0.3-3 mg/kg
Administration:

p.o., once daily for 5 days
Result:

Reduced the increased immobility time in sleep-deprived mice.
Reduced the increased plasma corticosterone level.
Reduced TNF-α and IL-1β level and increased BDNF mRNA expression in the hippocampus of sleep-deprived mice.

Chemical Information

CAS. Nr. 29741-10-4
Appearance Solid
Molecular Weight 462.36
Formel C₂₁H₁₈O₁₂
Color White to light yellow
SMILES

O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC(O)=C3C(C=C(C4=CC=C(O)C(O)=C4)OC3=C2)=O
Synonyms

Luteolin 7-glucuronide
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (3)

All Cell Proliferation/Viability Assay

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Journal Impact Factor

Nat Aging

Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice. [Abstract]

2024 Sep;4(9):1231-1248. PMID: 38951692

Luteolin 7-O-glucuronide purchased from MedChemExpress. Usage Cited in: Nat Aging. 2024 Sep;4(9):1231-1248. [Abstract]

Quantification of SA-β-Gal assay of UV-B-irradiated IMR90 fibroblasts, treated with the indicated compounds (3,4-Dicaffeoylquinic acid (Dicaffeoylquinic acid), etc.) at 1 μM concentration or 10 μg/mL for HK.
Nat Prod Bioprospect

Exploring anti-SARS-CoV-2 natural products: dual-viral target inhibition by delphinidin and the anti-coronaviral efficacy of deapio platycodin D. [Abstract]

2025 Jun 13;15(1):39. PMID: 40512442
Adv Redox Res

Food phytochemicals, epigallocatechin gallate and myricetin, covalently bind to the active site of the coronavirus main protease in vitro. [Abstract]

2021 Dec:3:100021. PMID: 35425933

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (270.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1628 mL

10.8141 mL

21.6282 mL

5 mM

0.4326 mL

2.1628 mL

4.3256 mL

10 mM

0.2163 mL

1.0814 mL

2.1628 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 5 mg/mL (10.81 mM); Clear solution; Need ultrasonic

Protocol 2

Add each solvent one by one: 0.5% Methyl cellulose/0.5% Tween-80 in Saline water

Solubility: 15.71 mg/mL (33.98 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Crascì L, et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83(11):901-911. [Content Brief]

[2]. Cho YC, et al. Anti-Inflammatory and Anti-Oxidative Effects of luteolin-7-O-glucuronide in LPS-Stimulated Murine Macrophages through TAK1 Inhibition and Nrf2 Activation. Int J Mol Sci. 2020 Mar 16;21(6):2007. [Content Brief]

[3]. Ryu D, et al. Luteolin-7-O-Glucuronide Improves Depression-like and Stress Coping Behaviors in Sleep Deprivation Stress Model by Activation of the BDNF Signaling. Nutrients. 2022 Aug 12;14(16):3314. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1628 mL	10.8141 mL	21.6282 mL	54.0704 mL
	5 mM	0.4326 mL	2.1628 mL	4.3256 mL	10.8141 mL
	10 mM	0.2163 mL	1.0814 mL	2.1628 mL	5.4070 mL
	15 mM	0.1442 mL	0.7209 mL	1.4419 mL	3.6047 mL
	20 mM	0.1081 mL	0.5407 mL	1.0814 mL	2.7035 mL
	25 mM	0.0865 mL	0.4326 mL	0.8651 mL	2.1628 mL
	30 mM	0.0721 mL	0.3605 mL	0.7209 mL	1.8023 mL
	40 mM	0.0541 mL	0.2704 mL	0.5407 mL	1.3518 mL
	50 mM	0.0433 mL	0.2163 mL	0.4326 mL	1.0814 mL
	60 mM	0.0360 mL	0.1802 mL	0.3605 mL	0.9012 mL
	80 mM	0.0270 mL	0.1352 mL	0.2704 mL	0.6759 mL
	100 mM	0.0216 mL	0.1081 mL	0.2163 mL	0.5407 mL

Keywords

Luteolin 7-O-glucuronide

3 Cited Publications

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Luteolin 7-O-glucuronide

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Publications Citing Use of MedChemExpress (MCE) Luteolin 7-O-glucuronide

Alle MMP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Luteolin 7-O-glucuronide Related Classifications

HY-N1463 Related Classifications