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Art. -Nr.: HY-161736

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ARN25499

ARN25499 (compound 15) is a CDC42 inhibitor. ARN25499 can be used in cancer-related research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₃H₂₆N₄O₂
Molecular Weight:390.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

ARN25499 Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

ARN25499 (compound 15) is a CDC42 inhibitor. ARN25499 can be used in cancer-related research^[1].

IC₅₀ & Target

Cdc42

Alle CDK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	9.7 μM Compound: 15; ARN25499	Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay	[PMID: 38866385]
SK-MEL-28	IC₅₀	13.5 μM Compound: 15; ARN25499	Antiproliferative activity against human SK-MEL-28 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay Antiproliferative activity against human SK-MEL-28 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay	[PMID: 38866385]
SK-MEL3	IC₅₀	8.1 μM Compound: 15; ARN25499	Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay	[PMID: 38866385]
SW480	IC₅₀	11.2 μM Compound: 15; ARN25499	Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay	[PMID: 38866385]

Chemical Information

Molecular Weight 390.48
Formel C₂₃H₂₆N₄O₂
SMILES

COC1=CC(NC2=NC(C3=CC=CC=C3)=CC(C4CCNCC4)=N2)=CC=C1OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Brindani N, et al. Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy. J Med Chem. 2024 Jun 27;67(12):10401-10424. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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ARN25499

Alle CDK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

ARN25499 Related Classifications

HY-161736 Related Classifications