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Art. -Nr.: HY-163374

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Cdc7-IN-20

Cdc7-IN-20 (EP-05) is an orally effective and selective Cdc7 inhibitor with IC₅₀ and K_i values of 0.93 and 0.11 nM, respectively. Cdc7-IN-20 has antitumor activity.

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Formel: C₁₅H₁₆N₄OS
Molecular Weight:300.38

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Cdc7-IN-20 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cdc7-IN-20 (EP-05) is an orally effective and selective Cdc7 inhibitor with IC₅₀ and K_i values of 0.93 and 0.11 nM, respectively. Cdc7-IN-20 has antitumor activity^[1].

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In Vitro

Cdc7-IN-20 (0.5, 1, 2 μM, 24 h) can inhibit the proliferation of COLO 205 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

COLO 205
Concentration:

0.5, 1, 2 μM
Incubation Time:

24 h
Result:

Inhibited the phosphorylation at Ser53 and Ser40 of MCM2 in a dose-dependent manner.

In Vivo

Cdc7-IN-20 (2, 4, 8 mg/kg, orally, for 3 consecutive days) has an antitumor effect in COLO 205 xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

COLO 205 xenograft mice model^[1]
Dosage:

2, 4, 8 mg/kg
Administration:

p.o. for 3 consecutive days
Result:

Inhibit the expression of p-MCM2 protein.

Chemical Information

Molecular Weight 300.38
Formel C₁₅H₁₆N₄OS
SMILES

O=C1NC(C(N)C(C)C)=NC2=C1SC(C3=CC=NC=C3)=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Fu M, et al. Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin-4-yl) thieno [3, 2-d] pyrimidin-4 (3H)-one derivatives as an orally active antitumor agent. Acta Pharmaceutica Sinica. B, 2024, 14(2): 893.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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Cdc7-IN-20

Alle CDK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Cdc7-IN-20 Related Classifications

HY-163374 Related Classifications