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Art. -Nr.: HY-117677

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Cdc7-IN-21

Cdc7-IN-21 (compound 10c) is a potent and selective Cdc7 inhibitor with an IC₅₀ of 0.07 nM. Cdc7-IN-21 can be used to study cancer.

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CAS. Nr.: 1330781-04-8
Formel: C₁₅H₁₇N₅OS
Molecular Weight:315.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Cdc7-IN-21 Chemical Structure

CAS. Nr.: 1330781-04-8

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
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Calculators
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Biologische Aktivität

Beschreibung

Cdc7-IN-21 (compound 10c) is a potent and selective Cdc7 inhibitor with an IC₅₀ of 0.07 nM. Cdc7-IN-21 can be used to study cancer^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
COLO 205	EC₅₀	1100 nM Compound: 10c	Cytotoxicity against human COLO205 cells after 3 days by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human COLO205 cells after 3 days by CellTiter-Glo luminescent cell viability assay	[PMID: 28533114]
COLO 205	EC₅₀	1100 nM Compound: Cpd I	Antiproliferative activity against human COLO205 cells assessed as reduction in cell growth after 3 days by CellTiter-Glo luminescence assay Antiproliferative activity against human COLO205 cells assessed as reduction in cell growth after 3 days by CellTiter-Glo luminescence assay	[PMID: 31895562]
HeLa	IC₅₀	250 nM Compound: 10c	Inhibition of Cdc7 in human HeLa cells assessed as reduction in MCM2 phosphorylation at ser40 residues after 7 hrs by Western blot analysis Inhibition of Cdc7 in human HeLa cells assessed as reduction in MCM2 phosphorylation at ser40 residues after 7 hrs by Western blot analysis	[PMID: 28533114]
HeLa	IC₅₀	250 nM Compound: Cpd I	Inhibition of CDC7 in human HeLa cells assessed as inhibition of MCM2 phosphorylation at Ser40 residue in human HeLa cells after 7 hrs by Western blot analysis Inhibition of CDC7 in human HeLa cells assessed as inhibition of MCM2 phosphorylation at Ser40 residue in human HeLa cells after 7 hrs by Western blot analysis	[PMID: 31895562]

Chemical Information

CAS. Nr. 1330781-04-8
Molecular Weight 315.39
Formel C₁₅H₁₇N₅OS
SMILES

O=C1N=C(CN2CCCC2)NC3=C1SC(C4=CNN=C4C)=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kurasawa O, et al. 2-Aminomethylthieno [3, 2-d] pyrimidin-4 (3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase[J]. Bioorganic & Medicinal Chemistry, 2017, 25(14): 3658-3670.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Cdc7-IN-21

Alle CDK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Cdc7-IN-21 Related Classifications

HY-117677 Related Classifications