CDK12 ligand-3
CDK12 ligand-3 is a molecular glucose degrading agent that targets the CDK12 protein (DC50 = 35 nM). CDK12 ligand-3 degrades CDK12, CDK13 and their regulatory subunit Cyclin K in a concentration dependent manner, and inhibits RNA polymerase II CTD (Ser2) phosphorylation. CDK12 ligand-3 exhibits potent anti proliferative activity against Jurkat cells. CDK12 ligand-3 can be used for research on cancers such as leukemia.
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- CAS. Nr.: 3093763-27-7
- Formel: C25H28ClN5O3S
- Molecular Weight:514.04
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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CAS. Nr. 3093763-27-7
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Molecular Weight 514.04
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Formel C25H28ClN5O3S
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SMILES
ClC1=CN=C(N[C@H]2CN(CCC2)C(C3=CC=CC=C3)=O)N=C1NC4=CC=CC=C4S(=O)(C(C)C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CDK12 ligand-3 Related Classifications
HY-177786 Related Classifications
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