CDK7-IN-11
CDK7-IN-11 is an orally active CDK7 inhibitor. CDK7-IN-11 exhibits high CDK7 inhibitory activity with IC50 value of 4.2 nM. CDK7-IN-11 can be effectively used for the research of diseases associated with CDK7.
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- CAS. Nr.: 2414896-32-3
- Formel: C26H28N6O2S
- Molecular Weight:488.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
CDK7 4.2 nM (IC50) |
In Vitro
CDK7-IN-11 (example 5) has inhibitory activity for CDK7 with IC50 value of 4.2 nM[1].
CDK7-IN-11 (72 h) inhibits cell proliferation in MDA-MB-468 cells and HepG2 cells with IC50 values of 14.0 nM and 3.0 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-468 cells, HepG2 cells
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Concentration:
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Incubation Time:72 h
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Result:Showed antiproliferative effect in cells.
Chemical Information
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CAS. Nr. 2414896-32-3
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Molecular Weight 488.60
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Formel C26H28N6O2S
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SMILES
N#CC1=CC(C2=CC([C@H](C)C(NC3=NC=C(CC)S3)=O)=CC=C2)=CN=C1NC(/C=C/CN(C)C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CDK7-IN-11 Related Classifications
HY-145655 Related Classifications
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