CDK7-IN-28
CDK7-IN-28 (CDK7-1276) is a potent CDK7 inhibitor(IC50＜5 nM). CDK7-IN-28 can inhibit proliferation of MDA-MB-468 cell line by blocking cell cycle and inhibiting DNA replication.
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- CAS. Nr.: 3034082-58-8
- Formel: C23H27F3N6O
- Molecular Weight:460.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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CDK7/Cyclin H/MNAT1 ＜5 nM (IC50) |
cdk2/cyclin A 6224 nM (IC50) |
CDK9/CyclinA 296 nM (IC50) |
CDK13/Cyclin K 152 nM (IC50) |
CDK7-IN-28 applies to MDA-MB-468 cells (IC50=2 nM), HepaRG cells (IC50 < 10 nM), NAl-H82 (IC50< 10 nM) has good antiproliferative activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:
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Concentration:
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Incubation Time:
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Result:
Chemical Information
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CAS. Nr. 3034082-58-8
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Molecular Weight 460.50
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Formel C23H27F3N6O
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SMILES
FC(F)(C1=CN=C(N=C1C2=CNC3=C2CCCN(C3=O)C4CC4)N[C@@H]5CNC6(CC5)CC6)F
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CDK7-IN-28 Related Classifications
HY-158170 Related Classifications
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