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Art. -Nr.: HY-190718

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CF-Eugenol

Name: CF-Eugenol
Brand: MedChemExpress
SKU: HY-190718
Availability: PreOrder

(Synonyms: Eugenol-clofibrate)

CF-Eugenol (Eugenol-clofibrate) is an orally effective PPAR-α activator. CF-Eugenol drives the expression of lipid-lowering genes and reduces serum triglyceride and total cholesterol in a dose-dependent manner. CF-Eugenol upregulates hepatic Nrf2 expression and activates the Nrf2/HO-1 axis to coordinate the expression of antioxidant and detoxifying enzymes. CF-Eugenol enhances antioxidant defense by increasing SOD activity and GSH content and reducing MDA accumulation. CF-Eugenol downregulates hepatic TNF-α and IL-6 to exert anti-inflammatory effects. CF-Eugenol reduces serum ALT, AST, and AKP and improves liver histopathology. CF-Eugenol can be used for research on hyperlipidemia.

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CAS. Nr.: 1449608-33-6
Formel: C₂₀H₂₁ClO₄
Molecular Weight:360.83

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CF-Eugenol Chemical Structure

CAS. Nr.: 1449608-33-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

PPAR-α

IL-6

Nrf2

SOD

HO-1

TNF-α

Alle PPAR Isoform-spezifische Produkte anzeigen :

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vivo

Lipid MetabolismOthers

Lipid Metabolism

CF-Eugenol (Eugenol-clofibrate) (0.1335-0.534 mmol/kg; intragastric administration; daily dosing; 7 consecutive days) dose-dependently reduces serum TG and TC in Triton WR 1339-induced hyperlipidemic KM mice^[1].

Others

CF-Eugenol (1.65 mmol/kg; intragastric administration; once daily for 30 consecutive days) causes significantly less liver injury than CF (Clofibrate) (HY-B0287) under long-term dosing, demonstrating superior liver safety^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

KM mice, body weight 20 g^[1]
Dosage:

0.1335 mmol/kg; 0.267 mmol/kg; 0.534 mmol/kg
Administration:

intragastric administration; daily dosing; 7 consecutive days
Result:

Reduced lipid levels in a dose-dependent manner.
Was more effective than CF in lowering TG levels.

Animal Model:

KM mice, body weight 20 g^[1]
Dosage:

1.65 mmol/kg
Administration:

intragastric administration; once daily for 30 consecutive days
Result:

In the CF-Eugenol group, liver weight and the liver-to-body-weight ratio were significantly lower than those in the CF group.
AST, ALT, and AKP levels decreased by 31.56%, 31.56%, and 49.35%, respectively, indicating a significant reduction in liver injury.
Oxidative stress was notably alleviated, as evidenced by increased SOD activity, elevated GSH content, and reduced MDA levels.

Related Protocols :

Chemical Information

CAS. Nr. 1449608-33-6
Molecular Weight 360.83
Formel C₂₀H₂₁ClO₄
SMILES

C=CCC1=CC=C(C(OC)=C1)OC(C(C)(C)OC2=CC=C(C=C2)Cl)=O
Synonyms

Eugenol-clofibrate
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Zhang X, et al. Optimizing clofibrate with eugenol contributes a novel hypolipidemic agent with minimal liver injury. Bioorganic & medicinal chemistry letters. 2026 Aug;137:130651. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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- In Vivo
Chemical Information
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CF-Eugenol

Alle PPAR Isoform-spezifische Produkte anzeigen

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Alle Interleukin Related Isoform-spezifische Produkte anzeigen