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Art. -Nr.: HY-180412

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Solimastat

(Synonyms: BB-3644)

Solimastat (BB-3644) is a potent metalloproteinase (MMP) inhibitor that blocks constitutive and antibody-stimulated CD30 shedding from cell surfaces with an IC₅₀ of 180 nM. Solimastat enhances persistence of anti-CD30 antibody Ki-3 on cells and favors its internalization. Solimastat enhances cytotoxic activity of Ki-3.dgA towards CD30⁺ L540 cells. Solimastat can be used for the research of CD30⁺ malignancies.

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CAS. Nr.: 226072-63-5
Formel: C₂₀H₃₂N₄O₅
Molecular Weight:408.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Solimastat Chemical Structure

CAS. Nr.: 226072-63-5

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Biologische Aktivität
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- In Vitro
Chemical Information
Reinheit & Dokumentation
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Calculators
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Bioz

Biologische Aktivität

Beschreibung

Alle MMP Isoform-spezifische Produkte anzeigen :

In Vitro

Solimastat (0-10⁵ nM, 10 min) potently inhibits PMA (HY-18739)-induced CD30 shedding from Karpas 299 cells in a dose-dependent manner^[1].
Solimastat (5 μM; 12 h) significantly increases internalization and surface persistence of Ki-3 MAb in Karpas 299 cells, while showing no effect on the process of antibody endocytosis itself^[1].
Solimastat (5 μM; 48 h) increases the cytotoxic activity of Ki-3.dgA immunotoxin against L540 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

CD30⁺ L540 and CD30^- HD-MyZ cells
Concentration:

5 μM
Incubation Time:

48 h
Result:

Had no influence on the cell viability of L540 and HD-MyZ cells alone.
Increased cytotoxic activity of Ki-3.dgA immunotoxin against L540 cells, with IC₅₀ shifts from 0.34 nM to 18.3 nM.

Chemical Information

CAS. Nr. 226072-63-5
Molecular Weight 408.50
Formel C₂₀H₃₂N₄O₅
SMILES

[C@@H]([C@@H](C(NO)=O)OC)(C(N[C@H](C(NC1=CC=CC=N1)=O)[C@@](C)(C)C)=O)CC(C)C
Synonyms

BB-3644
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002;98(2):210-215. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- In Vitro
Chemical Information
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Solimastat

Alle MMP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Solimastat Related Classifications

HY-180412 Related Classifications