Cernuumolide J
Cernuumolide J (TMJ-105) is an JAK2/STAT3 inhibitor. Cernuumolide J induces G2/M phase arrest and apoptosis in HEL leukemia cells by downregulating the phosphorylation of JAK2, STAT3, and Erk, and activating the phosphorylation of JNK and p38 MAPK. Cernuumolide J inhibits HEL leukemia cell growth in a time- and concentration-dependent manner, with an IC50 value of 1.79 μM. Cernuumolide J can be used for research in the field of anti-cancer therapy.
For research use only. We do not sell to patients.
- CAS No.: 2019163-02-9
- Formula: C24H34O8
- Molecular Weight:450.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
JNK3 |
Stat-3 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
18.36 μM
Compound: 10
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 27668963] |
| A549 | IC50 |
4.7 μM
Compound: 20
|
Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay
Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay
|
[PMID: 30869892] |
| BEL-7404 tumor cell line | IC50 |
7.35 μM
Compound: 10
|
Cytotoxicity against human Bel7404 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human Bel7404 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 27668963] |
| HCT-116 | IC50 |
5.51 μM
Compound: 10
|
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 27668963] |
| HL-60 | IC50 |
3 μM
Compound: 20
|
Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay
Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay
|
[PMID: 30869892] |
| MDA-MB-231 | IC50 |
7.53 μM
Compound: 10
|
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 27668963] |
Chemical Information
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CAS No. 2019163-02-9
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Molecular Weight 450.52
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Formula C24H34O8
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SMILES
CC(C)C(O[C@@H]1[C@]2([H])[C@@](C(C(O2)=O)=C)([H])[C@@H](C([C@@H](CCC[C@@]1(O)C)C)=O)OC(/C(C)=C\C)=O)=O
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Synonyms
TMJ-105
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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