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Cat. No.: HY-117421

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CM-579

CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC₅₀ values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.

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CAS No.: 1846570-40-8
Formule: C₂₉H₄₀N₄O₃
Masse moléculaire:492.65

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CM-579 Chemical Structure

CAS No.: 1846570-40-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

DNA Methyltransferase

32 nM (IC₅₀)

DNMT1

1.5 nM (Kd)

DNMT3A

92 nM (IC₅₀)

DNMT3B

1000 nM (IC₅₀)

G9a

16 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

Voir tous les produits spécifiques à Isoform DNA Methyltransferase :

Cellular Effect

Cell Line	Type	Value	Description	References
MM1.S	GI₅₀	3842 nM Compound: 6; CM-579	Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay	[PMID: 33661013]
OCI-Ly10	GI₅₀	<31 nM Compound: 12	Antiproliferative activity against human OCI-LY10 cells after 48 hrs by MTS assay Antiproliferative activity against human OCI-LY10 cells after 48 hrs by MTS assay	[PMID: 29890830]
OCI-Ly3	GI₅₀	202 nM Compound: 12	Antiproliferative activity against human OCI-LY3 cells after 48 hrs by MTS assay Antiproliferative activity against human OCI-LY3 cells after 48 hrs by MTS assay	[PMID: 29890830]

In Vitro

The K_d of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC₅₀s of 92 nM and 1000 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1846570-40-8
Masse moléculaire 492.65
Formule C₂₉H₄₀N₄O₃
SMILES

CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. San José-Enériz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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CM-579

Voir tous les produits spécifiques à Isoform Histone Methyltransferase

Voir tous les produits spécifiques à Isoform DNA Methyltransferase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CM-579 Related Classifications

HY-117421 Related Classifications