Cernuumolide J
Cernuumolide J (TMJ-105) is an JAK2/STAT3 inhibitor. Cernuumolide J induces G2/M phase arrest and apoptosis in HEL leukemia cells by downregulating the phosphorylation of JAK2, STAT3, and Erk, and activating the phosphorylation of JNK and p38 MAPK. Cernuumolide J inhibits HEL leukemia cell growth in a time- and concentration-dependent manner, with an IC50 value of 1.79 μM. Cernuumolide J can be used for research in the field of anti-cancer therapy.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 2019163-02-9
- Formule: C24H34O8
- Masse moléculaire:450.52
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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JNK3 |
Stat-3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
18.36 μM
Compound: 10
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 27668963] |
| A549 | IC50 |
4.7 μM
Compound: 20
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Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay
Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay
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[PMID: 30869892] |
| BEL-7404 tumor cell line | IC50 |
7.35 μM
Compound: 10
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Cytotoxicity against human Bel7404 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human Bel7404 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 27668963] |
| HCT-116 | IC50 |
5.51 μM
Compound: 10
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Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 27668963] |
| HL-60 | IC50 |
3 μM
Compound: 20
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Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay
Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay
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[PMID: 30869892] |
| MDA-MB-231 | IC50 |
7.53 μM
Compound: 10
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 27668963] |
Chemical Information
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CAS No. 2019163-02-9
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Masse moléculaire 450.52
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Formule C24H34O8
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SMILES
CC(C)C(O[C@@H]1[C@]2([H])[C@@](C(C(O2)=O)=C)([H])[C@@H](C([C@@H](CCC[C@@]1(O)C)C)=O)OC(/C(C)=C\C)=O)=O
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Synonyms
TMJ-105
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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