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Disulfiram

(Synonyms: Tetraethylthiuram disulfide; TETD)
143 Cited Publications
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Based on 143 publication(s) in Google Scholar

Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu2+ increases intracellular ROS levels and induces cuproptosis.

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  • Pureté: 99.77%
  • CAS No.: 97-77-8
  • Formule: C10H20N2S4
  • Masse moléculaire:296.54
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Disulfiram Chemical Structure
    Disulfiram Chemical Structure
  • Experimental Validation Results for Disulfiram
  • Experimental Validation Results for Disulfiram
  • Experimental Validation Results for Disulfiram
  • Experimental Validation Results for Disulfiram
  • Experimental Validation Results for Disulfiram
  • Experimental Validation Results for Disulfiram
CAS No.: 97-77-8
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  • Disulfiram Chemical Structure
    Disulfiram Chemical Structure
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    Disulfiram purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2025 Oct;26(10):1660-1672. [Abstract]

    Customer Validation
     Wild-type (WT) and Gsdmd−/− mice were intraperitoneally injected with 15 mg/kg (body weight) LPS and treated with normal saline, SK56 (1 mg/kg (body weight) i.v.) or 50 mg/kg (body weight) DSF, 50 mg/kg (body weight) DMF or 20 mg/kg (body weight) Necrosulfonamide (NSA) i.p. at 16 h after LPS injection. Blood AST, BUN, ALT and CK levels in wild-type and Gsdmd−/− mice treated as in a at day 2 after LPS injection; n = 6 mice.

  • 1/16

    Disulfiram purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Mar 1:36:96-111. [Abstract]

    Customer Validation
     (b) Cytotoxic effects of different concentrations CuCl2, CuCy, and Disulfiram (DSF) (12.5-200 μM) and (c) Combination therapy with different concentrations of CuCy (0.5 μM; 24 h) and DSF (0.5 μM; 24 h) on Ishikawa cells.

  • 1/16

    Disulfiram purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Mar 1:36:96-111. [Abstract]

    Customer Validation
     Disulfiram (DSF) (0.5 μM; 3-5 h). Vessel formation assay of HUVEC cells after drug treatment.

  • 1/16

    Disulfiram purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Mar 1:36:96-111. [Abstract]

    Customer Validation
     Disulfiram (DSF) (0.5 μM; 12-24 h). Protein levels of Caspase-9, Caspase-3, Cleaved Caspase-9, and Cleaved Caspase-3 were evaluated by Western blotting after 12 and 24 h of drug treatment.

  • 1/16

    Disulfiram purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Mar 1:36:96-111. [Abstract]

    Customer Validation
     Disulfiram (DSF) (0.5 μM; 12 h); CuCy (0.5 μM; 12 h). Mitochondrial membrane potential assay and DAPI staining.

  • 1/16

    Disulfiram purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Mar 1:36:96-111. [Abstract]

    Customer Validation
     Disulfiram (DSF) (0.5 μM; local injection; once every 3 days, 5 times in total); CuCy (0.5 μM; local injection; once every 3 days, 5 times in total). Results of H&E staining for subcutaneously transplanted tumors and organs (heart, liver, spleen, lung, kidney) in mice. Additionally, TUNEL staining results for the transplanted tumors.

  • Disulfiram