QA-68
QA-68 (QA-68-ZU81) is an effective PROTAC-class BRD9 degrader. QA-68 can inhibit cell cycle progression and cell colony formation. QA-68 has antiproliferative activity against acute myeloid leukemia (AML) cell lines
(Pink: BRD9 ligand (HY-131318); Blue: Cereblon ligand (HY-131318); Black: linker (HY-170315)).
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- Formule: C61H72N10O10S2
- Masse moléculaire:1169.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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BRD9 |
QA-68 (0-1000 nM; 24 h) exhibits antiproliferative activity against MV4-11, SKM-1 and Kasumi-1-luc+ cells, and inhibits BRD9 protein expression in MV4-11, SKM-1, SEM, NALM6, RS4;11[1].
QA-68 (0.1-1000 nM; 4 days) effectively inhibits SKM-1 cell cycle progression[1].
QA-68 (1000 nM; 12 days) inhibits colony formation of additional primary AML bone marrow and PBMC cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV4-11, SKM-1 and Kasumi-1-luc+ cells
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Concentration:0-1000 nM
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Incubation Time:24 h
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Result:Exhibited concentration-dependent inhibition of proliferation of MV4-11, SKM-1 and Kasumi-1-luc+ cells with IC50s of 1-10 nM in MV4;11 and SKM-1, and IC50 of 10-100 nM in Kasumi-1-luc +, respectively.
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Cell Line:SKM-1cells
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Concentration:0.1, 1, 10, 100 and 1000 nM
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Incubation Time:6 days
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Result:Effectively inhibited SKM-1 cell cycle progression.
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Cell Line:MV4-11, SKM-1, SEM, NALM6, RS4;11
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Concentration:0, 1, 10, 100 and 1000 nM
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Incubation Time:24 h
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Result:Inhibited BRD9 protein in all tested cell lines.
Chemical Information
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Masse moléculaire 1169.42
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Formule C61H72N10O10S2
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SMILES
CCCN1C=C(C2=C(C1=O)C=C(C(NC3CCS(CC3)(=O)=O)=O)S2)C4=CC=C(C5=C4)N(C=C5C)CC6CCN(CC6)C(CCC(N7CCN(CC7)C(N8CCN(CC8)CCC#CC9=CC=CC%10=C9CN(C%10=O)C%11CCC(NC%11=O)=O)=O)=O)=O
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Synonyms
QA-68-ZU81
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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