Solimastat
Solimastat (BB-3644) is a potent metalloproteinase (MMP) inhibitor that blocks constitutive and antibody-stimulated CD30 shedding from cell surfaces with an IC50 of 180 nM. Solimastat enhances persistence of anti-CD30 antibody Ki-3 on cells and favors its internalization. Solimastat enhances cytotoxic activity of Ki-3.dgA towards CD30+ L540 cells. Solimastat can be used for the research of CD30+ malignancies.
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- CAS No.: 226072-63-5
- Formule: C20H32N4O5
- Masse moléculaire:408.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Solimastat (0-105 nM, 10 min) potently inhibits PMA (HY-18739)-induced CD30 shedding from Karpas 299 cells in a dose-dependent manner[1].
Solimastat (5 μM; 12 h) significantly increases internalization and surface persistence of Ki-3 MAb in Karpas 299 cells, while showing no effect on the process of antibody endocytosis itself[1].
Solimastat (5 μM; 48 h) increases the cytotoxic activity of Ki-3.dgA immunotoxin against L540 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CD30+ L540 and CD30- HD-MyZ cells
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Concentration:5 μM
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Incubation Time:48 h
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Result:Had no influence on the cell viability of L540 and HD-MyZ cells alone.
Increased cytotoxic activity of Ki-3.dgA immunotoxin against L540 cells, with IC50 shifts from 0.34 nM to 18.3 nM.
Chemical Information
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CAS No. 226072-63-5
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Masse moléculaire 408.50
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Formule C20H32N4O5
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SMILES
[C@@H]([C@@H](C(NO)=O)OC)(C(N[C@H](C(NC1=CC=CC=N1)=O)[C@@](C)(C)C)=O)CC(C)C
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Synonyms
BB-3644
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Solimastat Related Classifications
HY-180412 Related Classifications
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