FGF2 - fibroblast growth factor 2 Gene
Also Known as BFGF; FGFB; FGF-2; HBGF-2
Species: Homo sapiens
About FGF2
This gene has 3 transcripts (splice variants), 121 orthologues and 21 paralogues. Broad expression in fat (RPKM 17.2), endometrium (RPKM 8.8) and 21 other tissues.
Summary
The protein encoded by this gene is a member of the Fibroblast Growth Factor (FGF) family. FGF Family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
FGF2 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001361665.2 | NP_001348594.1 | fibroblast growth factor 2 isoform 18 kDa |
| NM_002006.6 | NP_001997.5 | fibroblast growth factor 2 isoform 34 kDa |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables chemoattractant activity |
IDA
IDA: Inferred from direct assay
|
18059339 | GOA |
| enables chemokine binding |
IPI
IPI: Inferred from physical interaction
|
11708770 | GOA |
| enables cytokine activity |
IDA
IDA: Inferred from direct assay
|
18059339 | GOA |
| enables fibroblast growth factor receptor binding |
IPI
IPI: Inferred from physical interaction
|
2161540 | GOA |
| enables growth factor activity |
IDA
IDA: Inferred from direct assay
|
18059339 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
11708770 | GOA |
| enables integrin binding |
IDA
IDA: Inferred from direct assay
|
28302677 | GOA |
| enables nuclear receptor coactivator activity |
IDA
IDA: Inferred from direct assay
|
17500071 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9700203 | GOA |
| enables receptor-receptor interaction |
IDA
IDA: Inferred from direct assay
|
24157794 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
2161540 | GOA |
FGF2 Protein Structure
FGF: Fibroblast growth factor (162 - 282)
- 0
- 100
- 200
- 288 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
fibroblast growth factor 2 |
|
FGF2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
FGF2 | P09038 | FGFR1 | Homo sapiens | P11362 | 14613973 | |
|
Intra
|
FGF2 | P09038 | FGFR1 | Homo sapiens | P11362 | 23597563 | |
|
Intra
|
FGF2 | P09038 | FGFR1 | Homo sapiens | P11362 | 26267536 | |
|
Intra
|
FGF2 | P09038 | FGFR1 | Homo sapiens | P11362 | 10490103 | |
|
Intra
|
FGF2 | P09038 | PTX3 | Homo sapiens | P26022 | 22267482 | |
|
Intra
|
FGF2 | P09038 | PTX3 | Homo sapiens | P26022 | 20363749 | |
|
Intra
|
FGF2 | P09038 | PTX3 | Homo sapiens | P26022 | 22267482 | |
|
Intra
|
FGF2 | P09038 | PTX3 | Homo sapiens | P26022 | 22267482 |
Recombinant FGF2 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7004 | FGF basic/bFGF Protein, Human (146a.a) | P09038-4 (P143-S288) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7330 | FGF basic/bFGF Protein, Human (145a.a) | P09038-4 (A144-S288) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7331 | FGF basic/bFGF Protein, Human (154a.a) | P09038-4 (A135-S288) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70440 | FGF basic/bFGF Protein, Human (157a.a) | P09038-4 (G132-S288) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70440G | GMP FGF basic/bFGF Protein, Human | P09038-4 (G132-S288) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78877 | FGF basic/bFGF Protein, Human (Biotinylated, HEK293, His-Avi) | P09038-4 (P143-S288) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P7331A | FGF basic/bFGF Protein, Human (154a.a, His) | P09038-4 (A135-S288) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7330A | FGF basic/bFGF Protein, Human (145a.a, His) | P09038-4 (A144-S288) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700479 | FGF basic/bFGF Protein, Human (P. pastoris, N-His) | P09038-4 (P143-S288) | ≥ 90%, as determined by reducing SDS-PAGE. |
FGF2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80671 | FGF-2 Antibody (YA442) | WB, IP, FC, IHC-P | Human, Mouse |
| HY-P811254 | FGF2 Antibody | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P84024 | FGF-2 Antibody (YA3721) | IHC-P, ELISA | Human |
| HY-P84024A | FGF-2 Antibody (YA3721)(PBS only) | IHC-P, ELISA | Human |
| HY-P85160 | FGF-2 Antibody (YA4852) | WB, IHC-P, ICC/IF, ELISA | Human |
| HY-P89404 | FGF-2 Antibody (YA8853) | WB, ICC/IF, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Corneal Neovascularization |
|
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| Chronic Ulcer Of Skin |
|
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| Apert Syndrome |
|
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| Myelofibrosis |
|
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| Gastric Ulcer |
|
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| Diabetic Macular Edema |
|
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| Hemangioma |
|
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| Angiodysplasia |
|
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| Vitreoretinopathy, Neovascular Inflammatory |
|
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| Dupuytren Contracture |
|
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| Microvascular Complications Of Diabetes 1 |
|
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| Laryngitis |
|
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| Teratocarcinoma |
|
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| Crouzon Syndrome |
|
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| Central Neurocytoma |
|
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| Diverticulitis |
|
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| Neuroma |
|
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| Endometrial Cancer |
|
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| Proctitis |
|
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| Cholesteatoma Of Middle Ear |
|
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| Vascular Cancer |
|
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| Pericardial Effusion |
|
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| Malignant Pleural Mesothelioma |
|
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| Melorheostosis |
|
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| Craniosynostosis |
|
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| Ischemia |
|
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| Moyamoya Disease 1 |
|
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| Chondrosarcoma |
|
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| Pancreatic Adenocarcinoma |
|
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| Vascular Disease |
|
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| Poems Syndrome |
|
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| Kaposi Sarcoma |
|
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| Hepatic Veno-Occlusive Disease |
|
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| Osteonecrosis |
|
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| Retinal Detachment |
|
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| Fibrosarcoma |
|
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| Microvascular Complications Of Diabetes 5 |
|
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| Glioma |
|
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| Limb Ischemia |
|
|
| Supraglottis Squamous Cell Carcinoma |
|
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| Gingival Overgrowth |
|
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| Pituitary Adenoma |
|
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| Breast Cancer |
|
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| Pleomorphic Adenoma |
|
|
| Familial Glomangioma |
|
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| Decubitus Ulcer |
|
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| Bladder Cancer |
|
|
| Multiple Endocrine Neoplasia, Type I |
|
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| Hypophosphatemia |
|
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| Prolactinoma |
|
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| Pancreatic Cancer |
|
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| Arteriosclerosis |
|
|
| Pfeiffer Syndrome |
|
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| Pulmonary Hypertension |
|
|
| Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1 |
|
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| Renal Fibrosis |
|
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| Germ Cell And Embryonal Cancer |
|
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| Hepatocellular Carcinoma |
|
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| Prostate Cancer |
|
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| Vitreous Disease |
|
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| Macular Degeneration, Age-Related, 1 |
|
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| Lung Cancer |
|
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| Essential Thrombocythemia |
|
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| Demyelinating Disease |
|
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| Brain Cancer |
|
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| Insulin-Like Growth Factor I |
|
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| Capillary Hemangioma |
|
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| Dientamoebiasis |
|
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| Colorectal Cancer |
|
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| Upper Lip Cancer |
|
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| Chondroblastoma |
|
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| High Grade Glioma |
|
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| Dental Pulp Necrosis |
|
|
| Ichthyosis, Congenital, Autosomal Recessive 11 |
|
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| Mesothelioma, Malignant |
|
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| Myopia |
|
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| Retinal Degeneration |
|
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| Laryngeal Squamous Cell Carcinoma |
|
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| Rett Syndrome |
|
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| Heart Disease |
|
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| Ulcer Of Lower Limbs |
|
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| Neovascular Glaucoma |
|
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| Adenoid Cystic Carcinoma |
|
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| Capillary Disease |
|
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| Germ Cell Cancer |
|
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| Melanoma |
|
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| Interstitial Lung Disease 2 |
|
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| Ovarian Cancer |
|
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| Glioblastoma |
|
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| Buerger Disease |
|
|
| Paraganglioma |
|
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| Degeneration Of Macula And Posterior Pole |
|
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| Renal Cell Carcinoma, Nonpapillary |
|
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| Gingival Recession |
|
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| Pheochromocytoma |
|
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| Retinal Ischemia |
|
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| Exudative Vitreoretinopathy 1 |
|
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| Corneal Disease |
|
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| Intussusception |
|
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| Keratitis, Hereditary |
|
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| Scoliosis |
|
|
| Thanatophoric Dysplasia, Type I |
|
|
| Diabetic Polyneuropathy |
|
|
| Cataract |
|
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| Vitreous Detachment |
|
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| Muscular Dystrophy |
|
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| Kidney Cancer |
|
|
| Myeloproliferative Neoplasm |
|
|
| Kuhnt-Junius Degeneration |
|
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| Retinal Vascular Disease |
|
|
| Myelodysplastic Syndrome |
|
|
| Medulloblastoma |
|
|
| Osteoporosis |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Rhabdomyosarcoma |
|
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| Neuroblastoma |
|
|
| Autism Spectrum Disorder |
|
|
| Myocardial Infarction |
|
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| Cardiovascular Organ Benign Neoplasm |
|
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| Eye Degenerative Disease |
|
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| Type 2 Diabetes Mellitus |
|
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| Gastric Cancer |
|
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| Systemic Lupus Erythematosus |
|
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| Diabetes Mellitus |
|
|
| Myeloma, Multiple |
|
|
| Sensory System Disease |
|
|
| Cataract 23, Multiple Types |
|
|
| Autism |
|
|
| Esophageal Cancer |
|
|
| Gliosarcoma |
|
|
| Breast Adenocarcinoma |
|
|
| Hypertension, Essential |
|
|
| Peripheral Nervous System Disease |
|
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| Osteochondrodysplasia |
|
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| Eye Disease |
|
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| Gastrointestinal Stromal Tumor |
|
|
| Nervous System Disease |
|
|
| Connective Tissue Disease |
|
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| Rasopathy |
|
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| Skin Disease |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Congenital Nervous System Abnormality |
|
|
| Fundus Dystrophy |
|
|
| Retinitis Pigmentosa |
|
|
| Dilated Cardiomyopathy |
|
|
| Leukemia, Acute Myeloid |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | FGF2 | RGD | RGD:2609 |
| Macaca mulatta | FGF2 | VGNC | VGNC:100227 |
| Bos taurus | FGF2 | VGNC | VGNC:107260 |
| Canis familiaris | FGF2 | VGNC | VGNC:40847 |
| Mus musculus | FGF2 | MGD | MGI:95516 |
| Felis catus | FGF2 | VGNC | VGNC:78495 |
| Others | FGF2 | NCBI |