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GK444

GK444 (Compound 15a) is a HDAC1/2 inhibitor (IC50: 100 and 92 nM for HDAC1/2 respectively). GK444 inhibits Caco-2 cells with IC50 of 4.1 μM. GK444 also reduces TGF-β1 induced COL1A1 mRNA levels in primary normal human lung fibroblasts. GK444 inhibits Bleomycin (HY-108345)-induced lung fibrosis in mice.

For research use only. We do not sell to patients.

  • CAS No.: 3032392-39-2
  • Formula: C33H32N4O4
  • Molecular Weight:548.63
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • GK444 Chemical Structure
    GK444 Chemical Structure
CAS No.: 3032392-39-2
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To place orders, for customer services and technical support, please contact:

609-228-6898
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Use of MCE Products

All HDAC Isoforms

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    GK444 Chemical Structure
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  • GK444