Probenecid-d14
Based on 1 Customer Validation
Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels.
For research use only. We do not sell to patients.
- Purity: 99.54%
- CAS No.: 1189657-87-1
- Formula: C13H5D14NO4S
- Molecular Weight:299.45
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1189657-87-1
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Unlabeled Cas 57-66-9
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Appearance Solid
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Molecular Weight 299.45
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Formula C13H5D14NO4S
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Color White to off-white
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SMILES
S(N(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])(=O)(=O)C1=CC=C(C(O)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 30 mg/mL (100.18 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53(1):134-44. [Content Brief]
[3]. Bakos E, et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8. [Content Brief]
[4]. Greene TA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6(5):e20123. [Content Brief]
[5]. Silverman W, et al. Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008 Sep;295(3):C761-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3395 mL | 16.6973 mL | 33.3946 mL | 83.4864 mL |
| 5 mM | 0.6679 mL | 3.3395 mL | 6.6789 mL | 16.6973 mL | |
| 10 mM | 0.3339 mL | 1.6697 mL | 3.3395 mL | 8.3486 mL | |
| 15 mM | 0.2226 mL | 1.1132 mL | 2.2263 mL | 5.5658 mL | |
| 20 mM | 0.1670 mL | 0.8349 mL | 1.6697 mL | 4.1743 mL | |
| 25 mM | 0.1336 mL | 0.6679 mL | 1.3358 mL | 3.3395 mL | |
| 30 mM | 0.1113 mL | 0.5566 mL | 1.1132 mL | 2.7829 mL | |
| 40 mM | 0.0835 mL | 0.4174 mL | 0.8349 mL | 2.0872 mL | |
| 50 mM | 0.0668 mL | 0.3339 mL | 0.6679 mL | 1.6697 mL | |
| 60 mM | 0.0557 mL | 0.2783 mL | 0.5566 mL | 1.3914 mL | |
| 80 mM | 0.0417 mL | 0.2087 mL | 0.4174 mL | 1.0436 mL | |
| 100 mM | 0.0334 mL | 0.1670 mL | 0.3339 mL | 0.8349 mL |
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