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Referencia número: HY-115797

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LQFM030

LQFM030 is a novel small molecule MDM2 inhibitor. LQFM030 exhibits concentration dependent cytotoxicity in K562 cells (IC₅₀ = 0.28 mM). LQFM030 induces cell apoptosis through G0/G1 phase cell cycle arrest and increased Caspase activity. LQFM030 downregulates the mRNA expression of MDM2, MDMX, p73, MYC, and NF-κB. LQFM030 is commonly used in research on cancers such as leukemia.

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No. CAS: 2180931-49-9
Fòrmula: C₁₆H₁₉ClN₄O
Peso molecular:318.80

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

LQFM030 Chemical Structure

No. CAS: 2180931-49-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Caspase :

Ver todos los productos específicos de isoformas NF-κB :

Chemical Information

No. CAS 2180931-49-9
Peso molecular 318.80
Fòrmula C₁₆H₁₉ClN₄O
SMILES

CC(N1CCN(CC2=CN(C3=CC=C(Cl)C=C3)N=C2)CC1)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. de Oliveira Ribeiro H, et al. Small-molecule MDM2 inhibitor LQFM030-induced apoptosis in p53-null K562 chronic myeloid leukemia cells. Fundam Clin Pharmacol. 2020 Aug;34(4):444-457. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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Chemical Information
Pureza y Documentación
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LQFM030

Ver todos los productos específicos de isoformas Caspase

Ver todos los productos específicos de isoformas NF-κB