Cefadroxil
Based on 5 publication(s) in Google Scholar
Cefadroxil is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain.
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- Pureza: 98.58%
- No. CAS: 50370-12-2
- Fòrmula: C16H17N3O5S
- Peso molecular:363.39
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Cefadroxil
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Actividad biológica
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β-lactam |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | IC50 |
5400 μM
Compound: Cefadroxil
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TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 5 uM) in Caco-2 cells
TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 5 uM) in Caco-2 cells
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[PMID: 7592745] |
| HeLa | IC50 |
66 μM
Compound: Cefadroxil
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TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 50 uM) in PEPT2-expressing HeLa cells
TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 50 uM) in PEPT2-expressing HeLa cells
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[PMID: 7592745] |
| HeLa | IC50 |
870 μM
Compound: Cefadroxil
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TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 25 uM) in PEPT1-expressing HeLa cells
TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 25 uM) in PEPT1-expressing HeLa cells
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[PMID: 7592745] |
| S2 | IC50 |
1780 μM
Compound: Cefadroxil
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TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells
TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells
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[PMID: 12005172] |
| S2 | IC50 |
>2000 μM
Compound: Cefadroxil
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TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells
TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells
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[PMID: 12005172] |
Cefadroxil has similar inhibitory activity against most Gram-positive and Gram-negative bacteria as Cephalexin and Cephradine (HY-B1156), but is twice as active as Cephalexin (HY-B0200) against Streptococcus pyogenes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Cefadroxil (150 mg/kg; p.o.) exerts analgesic effects on mechanical allodynia in rats and mice with spared nerve injury (SNI) model, and also shows analgesic effect on cold pain in mice[4].
Cefadroxil (0.39-100 mg/kg; p.o.; single dose or three times at 24, 27, and 30 h) is more effective than Cephalexin in the rat streptococcal pneumonia model, with a larger AUC in lung tissue and a longer half-life[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 50370-12-2
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Appearance Solid
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Peso molecular 363.39
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Fòrmula C16H17N3O5S
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Color White to off-white
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SMILES
O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC([C@H](N)C3=CC=C(O)C=C3)=O)C1=O)O
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Synonyms
BL-S 578
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
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Journal Impact Factor
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Most Recent
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J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
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Solvente y solubilidad
H2O : 9.17 mg/mL (25.23 mM; ultrasonic and adjust pH to 3 with HCl)
DMSO : 5 mg/mL (13.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 4.55 mg/mL (12.52 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Buck RE, et al. Cefadroxil, a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1977 Feb;11(2):324-30. [Content Brief]
[2]. Posada MM, et al. Relevance of PepT1 in the intestinal permeability and oral absorption of cefadroxil. Pharm Res. 2013 Apr;30(4):1017-25. [Content Brief]
[3]. Hu Y, et al. Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice. Biochem Pharmacol. 2016 May 1;107:81-90. [Content Brief]
[4]. Han CJ, et al. Antinociceptive effects of cefadroxil and ceftriaxone in experimental animal models of pain. Neuro Endocrinol Lett. 2023 Jul 28;44(5):309-320. [Content Brief]
[5]. Tan Z, et al. Physiologically Based Pharmacokinetic Modeling of Cefadroxil in Mouse, Rat, and Human to Predict Concentration-Time Profile at Infected Tissue. Front Pharmacol. 2021 Dec 23;12:692741. [Content Brief]
[6]. Chisholm DR, et al. Therapeutic efficacy of cefadroxil and cephalexin for pneumonia in a rat test model. Antimicrob Agents Chemother. 1986 Jul;30(1):105-9. [Content Brief]
[7]. Chen X, et al. Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study. Biochem Pharmacol. 2017 May 1;131:89-97. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.7519 mL | 13.7593 mL | 27.5186 mL | 68.7966 mL |
| 5 mM | 0.5504 mL | 2.7519 mL | 5.5037 mL | 13.7593 mL | |
| 10 mM | 0.2752 mL | 1.3759 mL | 2.7519 mL | 6.8797 mL | |
| H2O | 15 mM | 0.1835 mL | 0.9173 mL | 1.8346 mL | 4.5864 mL |
| 20 mM | 0.1376 mL | 0.6880 mL | 1.3759 mL | 3.4398 mL | |
| 25 mM | 0.1101 mL | 0.5504 mL | 1.1007 mL | 2.7519 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cefadroxil Related Classifications
HY-B1190 Related Classifications
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