NU2058
Based on 1 Customer Validation
NU2058 (O6-(Cyclohexylmethyl)guanine) is a potent, competitive and guanine-based CDK inhibitor with IC50s of 17 μM and 26 μM for CDK2 and CDK1. NU2058 has anti-cancer activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.66%
- No. CAS: 161058-83-9
- Fòrmula: C12H17N5O
- Peso molecular:247.30
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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CDK1 26 μM (IC50) |
CDK2 17 μM (IC50) |
CDK2 12 μM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
>1000 μM
Compound: 20
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concentration required to reduce AGT activity to 50% of control rate in HT-29 cell extract.
concentration required to reduce AGT activity to 50% of control rate in HT-29 cell extract.
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[PMID: 11063604] |
| MCF7 | GI50 |
20 μM
Compound: 25
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Inhibition of MCF-7 human breast carcinoma cell proliferation
Inhibition of MCF-7 human breast carcinoma cell proliferation
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[PMID: 12139449] |
| MCF7 | IC50 |
24.2 μM
Compound: 1, NU2058
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Antiproliferative activity against human MCF7 cells after 3 days by SRB assay
Antiproliferative activity against human MCF7 cells after 3 days by SRB assay
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[PMID: 18069093] |
NU2058 (O6-(Cyclohexylmethyl)guanine) is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 μM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 161058-83-9
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Appearance Solid
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Peso molecular 247.30
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Fòrmula C12H17N5O
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Color White to off-white
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SMILES
NC1=NC(OCC2CCCCC2)=C3NC=NC3=N1
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Synonyms
O6-(Cyclohexylmethyl)guanine
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
DMSO : ≥ 32 mg/mL (129.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0437 mL | 20.2184 mL | 40.4367 mL | 101.0918 mL |
| 5 mM | 0.8087 mL | 4.0437 mL | 8.0873 mL | 20.2184 mL | |
| 10 mM | 0.4044 mL | 2.0218 mL | 4.0437 mL | 10.1092 mL | |
| 15 mM | 0.2696 mL | 1.3479 mL | 2.6958 mL | 6.7395 mL | |
| 20 mM | 0.2022 mL | 1.0109 mL | 2.0218 mL | 5.0546 mL | |
| 25 mM | 0.1617 mL | 0.8087 mL | 1.6175 mL | 4.0437 mL | |
| 30 mM | 0.1348 mL | 0.6739 mL | 1.3479 mL | 3.3697 mL | |
| 40 mM | 0.1011 mL | 0.5055 mL | 1.0109 mL | 2.5273 mL | |
| 50 mM | 0.0809 mL | 0.4044 mL | 0.8087 mL | 2.0218 mL | |
| 60 mM | 0.0674 mL | 0.3370 mL | 0.6739 mL | 1.6849 mL | |
| 80 mM | 0.0505 mL | 0.2527 mL | 0.5055 mL | 1.2636 mL | |
| 100 mM | 0.0404 mL | 0.2022 mL | 0.4044 mL | 1.0109 mL |
NU2058 Related Classifications
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