Senexin B
Based on 2 publication(s) in Google Scholar
Senexin B (SNX2-1-165; BCD-115) is a potent, highly water-soluble and bioavailable CDK8/19 inhibitor, with Kds of 140 nM for CDK8 and 80 nM for CDK19.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.09%
- No. CAS: 1449228-40-3
- Fòrmula: C27H26N6O
- Peso molecular:450.53
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Senexin B
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Customer Validation & Images
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WB
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
Actividad biológica
Descripciòn
IC50 & Target
[3]|
CDK19 80 nM (Kd) |
CDK8 140 nM (Kd) |
In Vitro
Senexin B inhibits CDK8/19 in low nanomolar range[1]. Senexin B is a newly optimized derivative of Senexin A. It has the same high selectivity for CDK8/19 and is more potent than Senexin A. Senexin B strongly reduces the emergence of estrogen independent cells. Senexin B shows synergy with fulvestrant in MCF7, T47D-ER/Luc and BT474[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 1449228-40-3
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Appearance Solid
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Peso molecular 450.53
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Fòrmula C27H26N6O
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Color White to off-white
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SMILES
N#CC1=CC2=C(NCCC3=CC=C4C=C(C(N5CCN(C)CC5)=O)C=CC4=C3)N=CN=C2C=C1
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Synonyms
SNX2-1-165; BCD-115
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
Corosolic acid inhibits cancer progression by decreasing the level of CDK19-mediated O-GlcNAcylation in liver cancer cells. [Abstract]2021 Sep 29;12(10):889. PMID: 34588426
Senexin B purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2021 Sep 29;12(10):889. [Abstract]
Senexin B (80 nM) significantly downregulated CDK19, OGT, and YAP protein levels and O-GlcNAcylation levels in Bel7402 and Bel-7404 cells.
Senexin B purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2021 Sep 29;12(10):889. [Abstract]
Senexin B (80 nM; 24 h) resulted in significantly inhibited cell proliferation in Bel7402 and Bel-7404 cells.
Senexin B purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2021 Sep 29;12(10):889. [Abstract]
Senexin B (80 nM; 2 weeks) significantly inhibited cell colony-formation capacity in Bel7402 and Bel-7404 cells.
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bioRxiv
2025 Nov 3:2025.11.02.685764. PMID: 41279360
Solvente y solubilidad
In Vitro:
DMSO : 6 mg/mL (13.32 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2196 mL | 11.0980 mL | 22.1961 mL | 55.4902 mL |
| 5 mM | 0.4439 mL | 2.2196 mL | 4.4392 mL | 11.0980 mL | |
| 10 mM | 0.2220 mL | 1.1098 mL | 2.2196 mL | 5.5490 mL |
Senexin B Related Classifications
HY-101800 Related Classifications
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