WIKI4
Based on 6 publication(s) in Google Scholar
WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 μM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.61%
- No. CAS: 838818-26-1
- Fòrmula: C29H23N5O3S
- Peso molecular:521.59
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-15147
XAV-939Tankyrase Inhibitor -
HY-12238
IWR-1Wnt Signaling Inhibitor -
HY-13968
JW 55PARP Inhibitor -
HY-10182
LaduviglusibGSK-3 Inhibitor -
HY-B0795
MHY1485mTOR Activator -
HY-147082
GA-017LATS1/2 Inhibitor -
HY-120697
MSABWnt/β-Catenin Inhibitor -
HY-10930
UNC0321G9a Inhibitor -
HY-10162
OlaparibPARP Inhibitor -
HY-10619
NiraparibPARP Inhibitor -
HY-12418
StenoparibPARP Inhibitor -
HY-10129
VeliparibPARP Inhibitor
Publications Citing Use of MedChemExpress (MCE) WIKI4
More
Customer Validation & Images
-
WB
-
RT-PCR
Actividad biológica
Descripciòn
IC50 & Target
[2]|
TNKS2 26 nM (IC50) |
In Vitro
WIKI4 (100 nM, 1 μM; 6 days; DLD1 cells) inhibits growth of DLD1 cells relative to DMSO controls in media containing low serum. WIKI4 inhibits expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling[1].
WIKI4 (1 μM; 2 hours, 4 hours, 6 hours, or 24 hours; DLD1 cells) significantly increases the steady-state abundance of AXIN1 and AXIN2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:DLD1 cells
-
Concentration:100 nM, 1 μM
-
Incubation Time:6 days
-
Result:Inhibited growth of DLD1 cells.
-
Cell Line:DLD1 cells
-
Concentration:1 μM
-
Incubation Time:2 hours,4 hours,6 hours, or 24 hours
-
Result:Significantly increased the steady-state abundance of AXIN1 and AXIN2.
Chemical Information
-
No. CAS 838818-26-1
-
Appearance Solid
-
Peso molecular 521.59
-
Fòrmula C29H23N5O3S
-
Color Off-white to light yellow
-
SMILES
O=C1N(CCCSC2=NN=C(C3=CC=NC=C3)N2C4=CC=C(OC)C=C4)C(C5=CC=CC6=CC=CC1=C56)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (6)
-
Journal Impact Factor
-
Most Recent
-
J Clin Invest
A pathogenic variant of AMOT leads to isolated X-linked congenital hydrocephalus due to N-terminal truncation. [Abstract]2025 Sep 2;135(17):e179438. PMID: 40892511 -
Discov Oncol
Aberrant expression of MRAS and HEG1 as the biomarkers for osimertinib resistance in LUAD. [Abstract]2024 Nov 19;15(1):678. PMID: 39560891 -
Dig Dis Sci
Tumor Necrosis Factor Ligand-Related Molecule 1A Regulates the Occurrence of Colitis-Associated Colorectal Cancer. [Abstract]2018 Sep;63(9):2341-2350. PMID: 29796912
WIKI4 purchased from MedChemExpress. Usage Cited in: Dig Dis Sci. 2018 Sep;63(9):2341-2350. [Abstract]
The expression of c-myc and Cyclin D1 is further decreased after adding β-catenin inhibitor (WIKI4) in protein level.
WIKI4 purchased from MedChemExpress. Usage Cited in: Dig Dis Sci. 2018 Sep;63(9):2341-2350. [Abstract]
The expression of c-myc and Cyclin D1 is further decreased after adding β-catenin inhibitor (WIKI4) in mRNA level.
-
Dig Dis
LncRNA H19 Promoted the Epithelial to Mesenchymal Transition and Metastasis in Gastric Cancer via Activating Wnt/β-Catenin Signaling. [Abstract]2022;40(4):436-447. PMID: 34348271 -
-
Solvente y solubilidad
In Vitro:
DMSO : 6.8 mg/mL (13.04 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
-
Ficha de datos (280 KB)
-
SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. James RG, et al. WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. PLoS One. 2012;7(12):e50457. [Content Brief]
[2]. Haikarainen T, et al. Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4. PLoS One. 2013 Jun 6;8(6):e65404. [Content Brief]
[3]. Sadava D, et al. The effect of brassinolide, a plant steroid hormone, on drug resistant small-cell lung carcinoma cells. Biochem Biophys Res Commun. 2017 Nov 4;493(1):783-787. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9172 mL | 9.5861 mL | 19.1721 mL | 47.9304 mL |
| 5 mM | 0.3834 mL | 1.9172 mL | 3.8344 mL | 9.5861 mL | |
| 10 mM | 0.1917 mL | 0.9586 mL | 1.9172 mL | 4.7930 mL |
WIKI4 Related Classifications
HY-16910 Related Classifications
Powered by Bioz