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Referencia número: HY-161736

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ARN25499

ARN25499 (compound 15) is a CDC42 inhibitor. ARN25499 can be used in cancer-related research.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₃H₂₆N₄O₂
Peso molecular:390.48

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

ARN25499 Chemical Structure

Tamaño

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

ARN25499 (compound 15) is a CDC42 inhibitor. ARN25499 can be used in cancer-related research^[1].

IC₅₀ & Target

Cdc42

Ver todos los productos específicos de isoformas CDK :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	9.7 μM Compound: 15; ARN25499	Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay	[PMID: 38866385]
SK-MEL-28	IC₅₀	13.5 μM Compound: 15; ARN25499	Antiproliferative activity against human SK-MEL-28 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay Antiproliferative activity against human SK-MEL-28 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay	[PMID: 38866385]
SK-MEL3	IC₅₀	8.1 μM Compound: 15; ARN25499	Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay	[PMID: 38866385]
SW480	IC₅₀	11.2 μM Compound: 15; ARN25499	Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay	[PMID: 38866385]

Chemical Information

Peso molecular 390.48
Fòrmula C₂₃H₂₆N₄O₂
SMILES

COC1=CC(NC2=NC(C3=CC=CC=C3)=CC(C4CCNCC4)=N2)=CC=C1OC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Brindani N, et al. Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy. J Med Chem. 2024 Jun 27;67(12):10401-10424. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
Referencias

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ARN25499

Ver todos los productos específicos de isoformas CDK

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

ARN25499 Related Classifications

HY-161736 Related Classifications