BD-7148

BD-7148 (100 nM; 1200 sec association, 1800 sec dissociation) binds to recombinant human BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, and BRD4-BD2 domain proteins with K_d values ranging from 26 nM to 240 nM, showing no selective binding to BRD4 domains over BRD2 or BRD3 domains^[1].
BD-7148 (Up to 1000 nM; 4 h) potently and selectively degrades BRD4 (DC₅₀ = 0.9 nM, Dmax = 99%) with no effect on BRD2 or BRD3 in MV4;11 human acute leukemia cells treated for 4 hours^[1].
BD-7148 (Up to 1000 nM; 4 h) potently degrades BRD4 (DC₅₀ = 0.2-13 nM, Dmax = 92-93%) with minimal to no effect on BRD2 and BRD3 in RS4;11, HL-60, and MOLM-13 human acute leukemia cells treated for 4 hours^[1].
BD-7148 (Multiple concentrations; 4 day) potently inhibits growth of MV4;11, MOLM-13, HL-60, RS4;11, MDA-MB-231, MDA-MB-453, MCF7, and T47D human cancer cells with IC₅₀ values of 3.3-59.9 nM, and is 8-189 times more potent than QCA276^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.