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Referencia número: HY-N13294

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Cernuumolide J

(Synonyms: TMJ-105)

Cernuumolide J (TMJ-105) is an JAK2/STAT3 inhibitor. Cernuumolide J induces G2/M phase arrest and apoptosis in HEL leukemia cells by downregulating the phosphorylation of JAK2, STAT3, and Erk, and activating the phosphorylation of JNK and p38 MAPK. Cernuumolide J inhibits HEL leukemia cell growth in a time- and concentration-dependent manner, with an IC₅₀ value of 1.79 μM. Cernuumolide J can be used for research in the field of anti-cancer therapy.

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No. CAS: 2019163-02-9
Fòrmula: C₂₄H₃₄O₈
Peso molecular:450.52

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Cernuumolide J Chemical Structure

No. CAS: 2019163-02-9

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IC₅₀ & Target

JNK3

Stat-3

Ver todos los productos específicos de isoformas JAK :

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	18.36 μM Compound: 10	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27668963]
A549	IC₅₀	4.7 μM Compound: 20	Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay	[PMID: 30869892]
BEL-7404 tumor cell line	IC₅₀	7.35 μM Compound: 10	Cytotoxicity against human Bel7404 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human Bel7404 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27668963]
HCT-116	IC₅₀	5.51 μM Compound: 10	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27668963]
HL-60	IC₅₀	3 μM Compound: 20	Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay	[PMID: 30869892]
MDA-MB-231	IC₅₀	7.53 μM Compound: 10	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27668963]

Chemical Information

No. CAS 2019163-02-9
Peso molecular 450.52
Fòrmula C₂₄H₃₄O₈
SMILES

CC(C)C(O[C@@H]1[C@]2([H])[C@@](C(C(O2)=O)=C)([H])[C@@H](C([C@@H](CCC[C@@]1(O)C)C)=O)OC(/C(C)=C\C)=O)=O
Synonyms

TMJ-105
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Wei X, et al. TMJ-105, an extract of Carpesium cernuum, induced G2/M phase arrest and apoptosis via the JAK2/STAT3 axis and MAPKs signaling pathway in leukemia HEL cells. Heliyon. 2024 Jul 5;10(14):e34115. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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100 mg

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Cernuumolide J

Ver todos los productos específicos de isoformas JAK

Ver todos los productos específicos de isoformas STAT

Ver todos los productos específicos de isoformas p38 MAPK

Ver todos los productos específicos de isoformas JNK

Ver todos los productos específicos de isoformas ERK

Actividad biológica

Chemical Information

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Referencias

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Cernuumolide J Related Classifications

HY-N13294 Related Classifications