Referencia número: HY-144315

Biologically Validated

CYD19

Name: CYD19
Brand: MedChemExpress
SKU: HY-144315
Price: 150.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Snail/HDAC-IN-1)

1 Cited Publications

Revisión del cliente

Based on 1 publication(s) in Google Scholar

CYD19 is a potent Snail/HDAC dual target inhibitor. CYD19 displays potent inhibitory activity against HDAC1 with an IC₅₀ of 0.405 μM and potent inhibition against Snail with a K_d of 0.18 μM. CYD19 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza : 99.76%
No. CAS: 2415281-52-4
Fòrmula: C₂₄H₂₁FN₈OS
Peso molecular:488.54

Almacenamiento:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

CYD19 Chemical Structure

No. CAS: 2415281-52-4

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Precio

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- MCE Validation Data
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]

HDAC1

0.405 μM (IC₅₀)

Snail

0.18 μM (Kd)

Ver todos los productos específicos de isoformas HDAC :

MCE Validation Data

HCT 116 cells were seeded at 1*10⁵ cells/well in a 24-well plate and were cultured overnight. Then, cells are treated with 0-75 nM CYD19 (HY-144315) for 48 hours to assess the expression of Snail-1 via Western blotting. The results demonstrated that CYD19 inhibited the expression of Snail-1 at 75 and 100 nM. Primary antibody: SNAI1 antibody (HY-P81135), β-actin antibody (HY-P80438).

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	0.466 μM Compound: 9n	Antiproliferative activity against human 786-0 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human 786-0 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
A498	GI₅₀	0.623 μM Compound: 9n	Antiproliferative activity against human A498 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human A498 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
A549	GI₅₀	0.886 μM Compound: 9n	Antiproliferative activity against human A549 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human A549 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
ACHN	GI₅₀	1.24 μM Compound: 9n	Antiproliferative activity against human ACHN cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human ACHN cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
BT-549	GI₅₀	0.296 μM Compound: 9n	Antiproliferative activity against human BT-549 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human BT-549 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
CCRF-CEM	GI₅₀	0.411 μM Compound: 9n	Antiproliferative activity against human CCRF-CEM cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human CCRF-CEM cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
COLO 205	GI₅₀	0.296 μM Compound: 9n	Antiproliferative activity against human COLO 205 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human COLO 205 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
DU-145	GI₅₀	0.461 μM Compound: 9n	Antiproliferative activity against human DU-145 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human DU-145 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
EKVX	GI₅₀	0.919 μM Compound: 9n	Antiproliferative activity against human EKVX cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human EKVX cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
HCC 2998	GI₅₀	0.677 μM Compound: 9n	Antiproliferative activity against human HCC 2998 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human HCC 2998 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
HCT-116	GI₅₀	0.494 μM Compound: 9n	Antiproliferative activity against human HCT-116 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human HCT-116 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
HCT-116	IC₅₀	0.0751 μM Compound: 9n	Antiproliferative activity against human HCT-116 cells assessed as cell viability at 1 uM incubated for 72 hrs by luminescence assay Antiproliferative activity against human HCT-116 cells assessed as cell viability at 1 uM incubated for 72 hrs by luminescence assay	[PMID: 34995925]
HCT-15	GI₅₀	0.424 μM Compound: 9n	Antiproliferative activity against human HCT-15 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human HCT-15 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
HL-60	GI₅₀	0.268 μM Compound: 9n	Antiproliferative activity against human HL-60 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human HL-60 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
HOP-62	GI₅₀	0.556 μM Compound: 9n	Antiproliferative activity against human HOP-62 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human HOP-62 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
HOP-92	GI₅₀	3.68 μM Compound: 9n	Antiproliferative activity against human HOP-92 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human HOP-92 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
Hs-578T	GI₅₀	0.429 μM Compound: 9n	Antiproliferative activity against human Hs-578T cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human Hs-578T cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
HT-29	GI₅₀	0.322 μM Compound: 9n	Antiproliferative activity against human HT-29 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human HT-29 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
IGROV-1	GI₅₀	0.558 μM Compound: 9n	Antiproliferative activity against human IGROV-1 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human IGROV-1 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
K562	GI₅₀	0.0487 μM Compound: 9n	Antiproliferative activity against human K562 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human K562 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
KM12	GI₅₀	0.284 μM Compound: 9n	Antiproliferative activity against human KM12 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human KM12 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
LOX IMVI	GI₅₀	0.665 μM Compound: 9n	Antiproliferative activity against human LOX IMVI cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human LOX IMVI cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
M14	GI₅₀	0.289 μM Compound: 9n	Antiproliferative activity against human M14 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human M14 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
Malme-3M	GI₅₀	1.83 μM Compound: 9n	Antiproliferative activity against human Malme-3M cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human Malme-3M cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
MCF7	GI₅₀	0.0518 μM Compound: 9n	Antiproliferative activity against human MCF7 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
MDA-MB-231	GI₅₀	0.854 μM Compound: 9n	Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
MDA-MB-435	GI₅₀	0.0361 μM Compound: 9n	Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
MDA-MB-468	GI₅₀	0.432 μM Compound: 9n	Antiproliferative activity against human MDA-MB-468 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human MDA-MB-468 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
MOLT-4	GI₅₀	0.508 μM Compound: 9n	Antiproliferative activity against human MOLT-4 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human MOLT-4 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
NCI/ADR-RES	GI₅₀	1.98 μM Compound: 9n	Antiproliferative activity against human NCI/ADR-RES cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human NCI/ADR-RES cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
NCI-H226	GI₅₀	2.7 μM Compound: 9n	Antiproliferative activity against human NCI-H226 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human NCI-H226 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
NCI-H23	GI₅₀	0.603 μM Compound: 9n	Antiproliferative activity against human NCI-H23 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human NCI-H23 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
NCI-H322M	GI₅₀	1.01 μM Compound: 9n	Antiproliferative activity against human NCI-H322M cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human NCI-H322M cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
NCI-H460	GI₅₀	0.395 μM Compound: 9n	Antiproliferative activity against human NCI-H460 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human NCI-H460 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
NCI-H522	GI₅₀	0.0488 μM Compound: 9n	Antiproliferative activity against human NCI-H522 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human NCI-H522 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
OVCAR-3	GI₅₀	0.202 μM Compound: 9n	Antiproliferative activity against human OVCAR-3 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human OVCAR-3 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
OVCAR-4	GI₅₀	1.66 μM Compound: 9n	Antiproliferative activity against human OVCAR-4 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human OVCAR-4 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
OVCAR-5	GI₅₀	0.657 μM Compound: 9n	Antiproliferative activity against human OVCAR-5 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human OVCAR-5 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
OVCAR-8	GI₅₀	0.483 μM Compound: 9n	Antiproliferative activity against human OVCAR-8 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human OVCAR-8 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
PC-3	GI₅₀	0.355 μM Compound: 9n	Antiproliferative activity against human PC-3 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human PC-3 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
RPMI-8226	GI₅₀	0.514 μM Compound: 9n	Antiproliferative activity against human RPMI-8226 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human RPMI-8226 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
RXF 393	GI₅₀	0.301 μM Compound: 9n	Antiproliferative activity against human RXF 393 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human RXF 393 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
SF-268	GI₅₀	1.12 μM Compound: 9n	Antiproliferative activity against human SF-268 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human SF-268 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
SF-295	GI₅₀	0.354 μM Compound: 9n	Antiproliferative activity against human SF-295 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human SF-295 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
SF-539	GI₅₀	0.282 μM Compound: 9n	Antiproliferative activity against human SF-539 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human SF-539 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
SK-MEL-2	GI₅₀	0.617 μM Compound: 9n	Antiproliferative activity against human SK-MEL-2 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human SK-MEL-2 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
SK-MEL-28	GI₅₀	2.83 μM Compound: 9n	Antiproliferative activity against human SK-MEL-28 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human SK-MEL-28 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
SK-MEL-5	GI₅₀	0.334 μM Compound: 9n	Antiproliferative activity against human SK-MEL-5 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human SK-MEL-5 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
SK-OV-3	GI₅₀	0.339 μM Compound: 9n	Antiproliferative activity against human SK-OV-3 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human SK-OV-3 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
SN12C	GI₅₀	1.25 μM Compound: 9n	Antiproliferative activity against human SN12C cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human SN12C cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
SNB-19	GI₅₀	0.536 μM Compound: 9n	Antiproliferative activity against human SNB-19 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human SNB-19 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
SNB-75	GI₅₀	0.198 μM Compound: 9n	Antiproliferative activity against human SNB-75 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human SNB-75 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
SR	GI₅₀	0.068 μM Compound: 9n	Antiproliferative activity against human SR cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human SR cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
SW-620	GI₅₀	0.426 μM Compound: 9n	Antiproliferative activity against human SW-620 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human SW-620 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
T47D	GI₅₀	1.12 μM Compound: 9n	Antiproliferative activity against human T47D cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human T47D cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
TK-10	GI₅₀	1.21 μM Compound: 9n	Antiproliferative activity against human TK-10 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human TK-10 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
U-251	GI₅₀	0.343 μM Compound: 9n	Antiproliferative activity against human U-251 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human U-251 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
UACC-257	GI₅₀	3.69 μM Compound: 9n	Antiproliferative activity against human UACC-257 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human UACC-257 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
UACC-62	GI₅₀	0.347 μM Compound: 9n	Antiproliferative activity against human UACC-62 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human UACC-62 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]
UO-31	GI₅₀	1.33 μM Compound: 9n	Antiproliferative activity against human UO-31 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay Antiproliferative activity against human UO-31 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay	[PMID: 34995925]

In Vitro

CYD19 (compound 9n) shows antiproliferative activity in HCT-116 cell lines with an IC₅₀ of 0.0751 μM. CYD19 shows a good inhibitory effect on NCI–H522 (GI₅₀=0.0488 μM), MDA-MB-435 (GI₅₀=0.0361 μM), and MCF7 (GI₅₀=0.0518 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

No. CAS 2415281-52-4
Appearance Solid
Peso molecular 488.54
Fòrmula C₂₄H₂₁FN₈OS
Color White to light yellow
SMILES

O=C(NC1=CC=C(F)C=C1N)C2=CC=C(CSC(N=C3NC4=NNC(C)=C4)=NN5C3=CC=C5)C=C2
Synonyms

Snail/HDAC-IN-1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Clin Transl Med

2026 Sep;16(9):e70793. PMID: 42745358

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (204.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0469 mL

10.2346 mL

20.4692 mL

5 mM

0.4094 mL

2.0469 mL

4.0938 mL

10 mM

0.2047 mL

1.0235 mL

2.0469 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

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The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
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- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Cui H, et al. Design and synthesis of dual inhibitors targeting snail and histone deacetylase for the treatment of solid tumour cancer. Eur J Med Chem. 2022;229:114082. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0469 mL	10.2346 mL	20.4692 mL	51.1729 mL
	5 mM	0.4094 mL	2.0469 mL	4.0938 mL	10.2346 mL
	10 mM	0.2047 mL	1.0235 mL	2.0469 mL	5.1173 mL
	15 mM	0.1365 mL	0.6823 mL	1.3646 mL	3.4115 mL
	20 mM	0.1023 mL	0.5117 mL	1.0235 mL	2.5586 mL
	25 mM	0.0819 mL	0.4094 mL	0.8188 mL	2.0469 mL
	30 mM	0.0682 mL	0.3412 mL	0.6823 mL	1.7058 mL
	40 mM	0.0512 mL	0.2559 mL	0.5117 mL	1.2793 mL
	50 mM	0.0409 mL	0.2047 mL	0.4094 mL	1.0235 mL
	60 mM	0.0341 mL	0.1706 mL	0.3412 mL	0.8529 mL
	80 mM	0.0256 mL	0.1279 mL	0.2559 mL	0.6397 mL
	100 mM	0.0205 mL	0.1023 mL	0.2047 mL	0.5117 mL

Bioz

Keywords

CYD19

1 Cited Publications

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CYD19

Publications Citing Use of MedChemExpress (MCE) CYD19

Ver todos los productos específicos de isoformas HDAC