SST0116CL1
SST0116CL1 is a HSP90 inhibitor (IC50: 0.21 μM). SST0116CL1 binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 induces degradation of Her2 in BT-474 cell (IC50: 0.2 μM). SST0116CL1 has antiproliferative activity and inhibits tumor growth. SST0116CL1 can be used for the study of leukemia, gastric and ovarian carcinoma.
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- No. CAS: 1799802-29-1
- Fòrmula: C22H31ClN4O6
- Peso molecular:482.96
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
SST0116CL1 has antiproliferative activity on different tumor cell lines, with IC50s of 0.81 μM (A431), 0.11 μM (NCI-H460), 0.81 μM (A2780), 0.40 μM (MV4;11), 0.23 μM (GTL-16), 0.62 μM (BT474), 0.34 μM (HT-1080)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1799802-29-1
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Peso molecular 482.96
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Fòrmula C22H31ClN4O6
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SMILES
O=C(NCC)C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1NC(CCN3CCOCC3)=O.Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SST0116CL1 Related Classifications
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