TD034
Based on 1 Customer Validation
TD034 is a selective, reversible and noncovalent HDAC11 inhibitor with an IC50 of 5.1 nM and a Ki of 1.5 nM. TD034 does not inhibit other HDACs or sirtuins. TD034 inhibits the defatty acylation of SHMT2 (HDAC11 substrate). TD034 decreases the YAP1 level via HDAC11 inhibition. TD034 can be used for the study of lung cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.77%
- No. CAS: 3030718-42-1
- Fòrmula: C45H64N4O6
- Peso molecular:757.01
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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HDAC11 5.1 nM (IC50) |
HDAC11 1.5 nM (Ki) |
YAP1 |
TD034 significantly increases the fatty acylation level of SHMT2 at 2 μM in HEK293T[1].
TD034 (5-10 μM) results in a significant reduction of YAP1 protein levels and a decrease in the mRNA levels of two YAP1 target genes, CTGF and CYR61 in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3030718-42-1
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Appearance Solid
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Peso molecular 757.01
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Fòrmula C45H64N4O6
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Color Off-white to light yellow
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SMILES
CCCCCCCCCCC[C@@H]1[C@H](O1)C(CCCCC[C@@H]2NC([C@]3([H])N(CCCC3)C([C@@H](NC([C@@H](NC2=O)CC4=CC=CC=C4)=O)CC5=CC=CC=C5)=O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
DMSO : 100 mg/mL (132.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3210 mL | 6.6049 mL | 13.2099 mL | 33.0247 mL |
| 5 mM | 0.2642 mL | 1.3210 mL | 2.6420 mL | 6.6049 mL | |
| 10 mM | 0.1321 mL | 0.6605 mL | 1.3210 mL | 3.3025 mL | |
| 15 mM | 0.0881 mL | 0.4403 mL | 0.8807 mL | 2.2016 mL | |
| 20 mM | 0.0660 mL | 0.3302 mL | 0.6605 mL | 1.6512 mL | |
| 25 mM | 0.0528 mL | 0.2642 mL | 0.5284 mL | 1.3210 mL | |
| 30 mM | 0.0440 mL | 0.2202 mL | 0.4403 mL | 1.1008 mL | |
| 40 mM | 0.0330 mL | 0.1651 mL | 0.3302 mL | 0.8256 mL | |
| 50 mM | 0.0264 mL | 0.1321 mL | 0.2642 mL | 0.6605 mL | |
| 60 mM | 0.0220 mL | 0.1101 mL | 0.2202 mL | 0.5504 mL | |
| 80 mM | 0.0165 mL | 0.0826 mL | 0.1651 mL | 0.4128 mL | |
| 100 mM | 0.0132 mL | 0.0660 mL | 0.1321 mL | 0.3302 mL |
TD034 Related Classifications
HY-176542 Related Classifications
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