TH-6
Based on 1 publication(s) in Google Scholar
TH-6 is a potent HDAC inhibitor with IC50s of 0.115, 0.135, 0.242, 0.138, 2.120 µM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively. TH-6 inhibits cell migration and invasion. TH-6 induces apoptosis and cell cycle arrest at G2/M phase. TH-6 shows anti-tumor activity.
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- Pureza: 95.00%
- No. CAS: 3031349-25-1
- Fòrmula: C22H24FN3O5
- Peso molecular:429.44
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
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Publications Citing Use of MedChemExpress (MCE) TH-6
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Actividad biológica
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HDAC1 0.115 μM (IC50) |
HDAC2 0.135 μM (IC50) |
HDAC3 0.242 μM (IC50) |
HDAC6 0.138 μM (IC50) |
HDAC8 2.120 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| H22 | IC50 |
26 nM
Compound: TH-6
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Antiproliferative activity against mouse H22 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against mouse H22 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
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[PMID: 35926141] |
| HCT-116 | IC50 |
28 nM
Compound: TH-6
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
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[PMID: 35926141] |
| HepG2 | IC50 |
29 nM
Compound: TH-6
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
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[PMID: 35926141] |
| HFL1 | IC50 |
13 nM
Compound: TH-6
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Antiproliferative activity against human HFL1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human HFL1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
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[PMID: 35926141] |
| HUVEC | IC50 |
0.271 μM
Compound: TH-6
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Antiproliferative activity against HUVEC cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
Antiproliferative activity against HUVEC cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
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[PMID: 35926141] |
| K562 | IC50 |
0.018 μM
Compound: TH-6
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Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
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[PMID: 35926141] |
| MCF7 | IC50 |
27 nM
Compound: TH-6
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
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[PMID: 35926141] |
| MDA-MB-231 | IC50 |
30 nM
Compound: TH-6
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
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[PMID: 35926141] |
TH-6 (0-2 µM) shows antiproliferative activities in cancer cell lines and normal human lung cells[1].
TH-6 (0-10 µM) inhibits tubulin polymerization with an IC50 value of 4.06 µM[1].
TH-6 (0.03, 0.1, 0.3 1 µM; 24 h) increases the expression of Ac-α-Tubulin and AC-Histone H3 in HepG2 cells[1].
TH-6 (7.5, 15, 30 nM) induces apoptosis and cell cycle arrest at G2/M phase[1].
TH-6 (0-30 nM) decreases the MMP and increase ROS levels of HepG2 cells in a dose-dependent manner[1].
TH-6 (7.5, 15, 30 nM; 48 h) inhibits cell migration and invasion in MDA-MB-231 cells and suppress the migration of HUVECs in a concentration-dependent manner[1].
TH-6 shows favorable liver microsomal stability in vitro with t1/2 of 50.3 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562, GepG2, HCT-116, MDA-MB-231, H22, MCF-7, HFL-1 cells
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Concentration:0-2 µM
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Incubation Time:
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Result:Showed antiproliferative activities with an IC50 values of 18, 29, 28, 30, 26, 27, 134 nM for K562, GepG2, HCT-116, MDA-MB-231, H22, MCF-7, HFL-1 cells, respectively.
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Cell Line:HepG2 cells
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Concentration:0.03, 0.1, 0.3 1 µM
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Incubation Time:24 h
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Result:Increased the intracellular levels of HDAC6 substrate acetyl-α-tubulin and the HDAC1/2/3 substrate acetyl-histone H3 in a dose-dependent manner.
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Cell Line:HepG2 cells
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Concentration:7.5, 15, 30 nM
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Incubation Time:
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Result:Induced cell cycle arrest at G2/M phase with decreased the expression of Cdc2, Cdc25c, and Cyclin B1 proteins in a dose dependent manner.
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Cell Line:HepG2 cells
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Concentration:7.5, 15, 30 nM
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Incubation Time:
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Result:Showed an accumulation of apoptotic cells from 27.04 to 50.54% and upregulated the expression of the pro-apoptotic protein (Bax and Bad) and downregulated the expression of the antiapoptotic protein (Bcl-2 and Bcl-xL) in a dose-dependent manner.
TH-6 (20 mg/kg) shows antivascular activity and a good cardiovascular safety profile in mouse[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4-5 weeks, 18-22 g female ICR mice (H22 allograft mouse model)[1]
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Dosage:10, 20 mg/kg
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Administration:I.v.; daily for 21 days
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Result:Reduced tumor weights at day 21 by 82% and did not affect body weight during treatment, indicating the low toxicity.
Chemical Information
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No. CAS 3031349-25-1
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Appearance Solid
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Peso molecular 429.44
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Fòrmula C22H24FN3O5
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Color Light yellow to khaki
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SMILES
ONC(/C=C/C(C=C1CNC(C2=C(N3CCOCC3)C=CC(F)=C2)=O)=C(C=C1)OC)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : 50 mg/mL (116.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3286 mL | 11.6431 mL | 23.2861 mL | 58.2153 mL |
| 5 mM | 0.4657 mL | 2.3286 mL | 4.6572 mL | 11.6431 mL | |
| 10 mM | 0.2329 mL | 1.1643 mL | 2.3286 mL | 5.8215 mL | |
| 15 mM | 0.1552 mL | 0.7762 mL | 1.5524 mL | 3.8810 mL | |
| 20 mM | 0.1164 mL | 0.5822 mL | 1.1643 mL | 2.9108 mL | |
| 25 mM | 0.0931 mL | 0.4657 mL | 0.9314 mL | 2.3286 mL | |
| 30 mM | 0.0776 mL | 0.3881 mL | 0.7762 mL | 1.9405 mL | |
| 40 mM | 0.0582 mL | 0.2911 mL | 0.5822 mL | 1.4554 mL | |
| 50 mM | 0.0466 mL | 0.2329 mL | 0.4657 mL | 1.1643 mL | |
| 60 mM | 0.0388 mL | 0.1941 mL | 0.3881 mL | 0.9703 mL | |
| 80 mM | 0.0291 mL | 0.1455 mL | 0.2911 mL | 0.7277 mL | |
| 100 mM | 0.0233 mL | 0.1164 mL | 0.2329 mL | 0.5822 mL |
TH-6 Related Classifications
HY-149029 Related Classifications
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