Ang - angiogenin, ribonuclease, RNase A family, 5 Gene

Also Known as Ang1; Rnase5; Rnase5a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11727

Summary

This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate Cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009]

Ang Products (2)

mRNA Protein Name
NM_001161731.3 NP_001155203.1 angiogenin precursor
NM_007447.4 NP_031473.1 angiogenin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA nuclease activity IDA
IDA: Inferred from direct assay
8448182 MGI
enables tRNA-specific ribonuclease activity IDA
IDA: Inferred from direct assay
24752898 MGI
Biological Process GO Annotation Evidence References Source
involved in antibacterial humoral response IDA
IDA: Inferred from direct assay
12548285 MGI
involved in antifungal humoral response IDA
IDA: Inferred from direct assay
12548285 MGI
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
12548285 MGI
involved in cellular response to osmotic stress IDA
IDA: Inferred from direct assay
24752898 MGI
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
12548285 MGI
involved in hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
27518564 MGI
involved in innate immune response IDA
IDA: Inferred from direct assay
12548285 MGI
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
24752898 MGI
involved in negative regulation of cellular senescence IDA
IDA: Inferred from direct assay
33758201 MGI
involved in negative regulation of translation in response to stress IMP
IMP: Inferred from mutant phenotype
27518564 MGI
involved in rRNA transcription IDA
IDA: Inferred from direct assay
33758201 MGI
involved in rRNA transcription IMP
IMP: Inferred from mutant phenotype
27518564 MGI
involved in response to yeast IDA
IDA: Inferred from direct assay
12548285 MGI
involved in tRNA destabilization IDA
IDA: Inferred from direct assay
33986151 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
33758201 MGI
located in growth cone IDA
IDA: Inferred from direct assay
17468498 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
17468498 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
33758201 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

angiogenin

  • angiogenin, ribonuclease A family, member 1

  • angiogenin-1

  • ribonuclease 5

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13948 Angiotensin II human 99.98% Unkown
HY-13948A Angiotensin II human acetate 99.81% Unkown
HY-B0561 Spironolactone 99.81% Yes
HY-B0202 Irbesartan 99.95% Yes
HY-B0935 Benzyl benzoate Inhibitor 99.98% Yes
HY-13948B Angiotensin II human TFA 98.29% Unkown
HY-B0202A Irbesartan hydrochloride / Unkown
HY-B0202R Irbesartan (Standard) / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99116 Faricimab Inhibitor 97.97% Unkown

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-P2983 Angiotensin-converting enzyme / Phase 4
HY-12403 Talfirastide 99.91% Phase 3
HY-P4073 ANG1005 98.83% Phase 3
HY-137455 Terevalefim Activator 99.37% Phase 3
HY-177671 Zodasiran Inhibitor 95.26% Phase 3
HY-177671A Zodasiran sodium Inhibitor / Phase 3
HY-109041 Razuprotafib 98.0% Phase 2
HY-147243 Ansornitinib Inhibitor 98.23% Phase 2
HY-124397 N-Acetylcolchinol phosphate Inhibitor / Phase 2
Inhibitory Antibodies (7)
Cat. No. Product Name Effect
Purity Phase
HY-P99546 Trebananib Inhibitor ≥99.0% Phase 3
HY-P99330 Vanucizumab Inhibitor 95.12% Phase 2
HY-P99510 Zansecimab Inhibitor ≥95.0% Phase 2
HY-P990689 Zifibancimig Inhibitor 99.00% Phase 2
HY-P99036 Nesvacumab Inhibitor 99.11% Phase 1
HY-P991663 AMG-780 Inhibitor / Phase 1
HY-P991415 ASKG-712 Antagonist / Phase 1

Pre-clinical Phase

Bioactive Molecules (61)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0216 A 779 Antagonist 99.55% Unkown
HY-P1236 Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse Inhibitor 99.55% Unkown
HY-160187 AAA Antagonist 99.52% Unkown
HY-15477 YS-49 99.98% Unkown
HY-N0515 Ophiopogonin D 99.80% Unkown
HY-151483 TK-129 Inhibitor ≥98.0% Unkown
HY-12403A Talfirastide acetate 99.76% Yes
HY-P3136 TRV055 99.47% Unkown
HY-13948F1 Angiotensin II human, FAM-labeled Activator 99.58% Unkown
HY-N7665 Prosaikogenin G 98.35% Unkown
HY-P3136A TRV055 hydrochloride Agonist 98.88% Unkown
HY-N2445 Flavokawain C 99.79% Unkown
HY-P1415A Norleual TFA 99.52% Unkown
HY-13948BS Angiotensin II human-13C6,15N TFA 99.46% Unkown
HY-15477A YS-49 monohydrate 99.56% Unkown
HY-13948F Biotin-Ahx-Angiotensin II human 99.86% Unkown
HY-P10933 PRO20 Antagonist 99.16% Unkown
HY-P1236A Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse TFA Inhibitor 99.32% Unkown
HY-15778A AVE 0991 sodium salt Agonist 99.47% Unkown
HY-N2666 5α-Hydroxycostic acid Inhibitor 95.17% Unkown
HY-15193B EMD638683 (S-Form) Inhibitor 99.72% Unkown
HY-B0202S Irbesartan-d4 Antagonist 99.46% Unkown
HY-135795 1-Cyclohexyl-3-dodecyl urea Inhibitor 98.0% Unkown
HY-16707 CH 5450 Inhibitor 98.04% Unkown
HY-172699A DSPE-PEG3400-ANG 95.0% Unkown
HY-B0561S4 Spironolactone-d6-1 99.26% Unkown
HY-RS00684 ANG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W342283 Diminazene / Unkown
HY-109041A Razuprotafib sodium / Unkown
HY-184265 Mito-Esculetin / Unkown
HY-102093A ZD 7155 / Unkown
HY-103247 EMD 66684 Antagonist / Unkown
HY-105506 EXP-7711 Antagonist / Unkown
HY-108120 L-162537 Inhibitor / Unkown
HY-114164E Rabbit Thrombin / Unkown
HY-121313 Embusartan Antagonist / Unkown
HY-129412 A-74273 Inhibitor / Unkown
HY-131162 Chymase Activator / Unkown
HY-142694 DCN1-UBC12-IN-2 Inhibitor / Unkown
HY-160043 AL6 aptamer sodium / Unkown
HY-162729 LSD1-IN-34 Inhibitor / Unkown
HY-163859 LSD1-IN-33 Inhibitor / Unkown
HY-169026 DCN1-IN-2 Inhibitor / Unkown
HY-172698 DSPE-PEG1000-ANG / Unkown
HY-172699 DSPE-PEG2000-ANG / Unkown
HY-172700 DSPE-PEG5000-ANG / Unkown
HY-19165 CI-996 Antagonist / Unkown
HY-19200 RB-105 Inhibitor / Unkown
HY-B0202S2 Irbesartan-d6-1 / Unkown
HY-P0216A A-779 TFA Antagonist / Unkown
HY-P10597 Angiotensin II type 1 receptor (181-187) Activator / Unkown
HY-P11389 (Sar1,Gly8)-Angiotensin II Antagonist / Unkown
HY-P1415 Norleual / Unkown
HY-P3545 5-Valine-angiotensin I Activator / Unkown
HY-167886 GA 0113 Antagonist / Unkown
HY-180796 PKM2 agonist-1 Agonist / Unkown
HY-B0202AS Irbesartan-d7 hydrochloride / Unkown
HY-B0202S3 Irbesartan-d7 / Unkown
HY-RS16832 Ang Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23274 Ang Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24191 Agt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992323 BI-836880 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ang NCBI NCBI:283