Il13 - interleukin 13 Gene

Also Known as Il-13

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16163

About Il13

Chromosome 11: 53,522,151-53,525,529 reverse strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 88 orthologues and is associated with 55 phenotypes. Biased expression in thymus adult (RPKM 2.8), testis adult (RPKM .6) and 2 other tissues.

Summary

Predicted to enable interleukin-13 receptor binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation. Acts upstream of or within cellular response to cytokine stimulus; inflammatory response; and positive regulation of immune effector process. Located in cytoplasm; external side of plasma membrane; and extracellular space. Is expressed in gut; liver; male reproductive gland or organ; and thymus. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13). [provided by Alliance of Genome Resources, Apr 2022]

Il13 Products (1)

mRNA Protein Name
NM_008355.3 NP_032381.1 interleukin-13 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23972995 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to cytokine stimulus IDA
IDA: Inferred from direct assay
19666510 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
15647285 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
24906148 MGI
acts upstream of or within positive regulation of immunoglobulin production IGI
IGI: Inferred from genetic interaction
15944273 MGI
acts upstream of or within positive regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
15944273 MGI
involved in positive regulation of macrophage activation IMP
IMP: Inferred from mutant phenotype
19841166 MGI
acts upstream of or within positive regulation of mast cell degranulation IGI
IGI: Inferred from genetic interaction
15944273 MGI
acts upstream of or within positive regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
15944273 MGI
acts upstream of or within response to nematode IDA
IDA: Inferred from direct assay
26644468 MGI
acts upstream of or within response to selenium ion IDA
IDA: Inferred from direct assay
26644468 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11737071 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
18792410 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
15087456 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il13 Protein Structure

IL13

IL13: pfam03487 (20 - 129)

  • 0
  • 100
  • 131 a.a.
Protein Preferred Names Protein Names

interleukin-13

  • T-cell activation protein P600

Il13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Il13 P20109 Il13ra2 Mus musculus O88786
Anti Bait CoIP
27629921
Intra
Il13 P20109 Il13ra2 Mus musculus O88786
Anti Bait CoIP
23972995
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Il13 Proteins

Cat. No. Product Name Accession Purity
HY-P7076A IL-13 Protein, Mouse (CHO, His) P20109 (P22-F131) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70460 IL-13 Protein, Mouse P20109 (S26-F131) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72595 IL-13 Protein, Mouse (HEK293, His) P20109 (P22-F131) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73168 IL-13 Protein, Mouse (HEK293) P20109 (A19-F131) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700192AF Animal-Free IL-13 Protein, Mouse (His) P20109 (P22-F131) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0539 Desloratadine 99.98% Yes
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9926 Dupilumab Inhibitor ≥99.2% Unkown
HY-P99025 Lebrikizumab Inhibitor 99.90% Unkown
HY-P99053 Tralokinumab Inhibitor 99.12% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-154792 Pyrrolidone carboxylic acid / Phase 4
HY-155830 Morcamilast Inhibitor 98.92% Phase 2
HY-144683 PF-07038124 Inhibitor / Phase 2
Inhibitory Antibodies (17)
Cat. No. Product Name Effect
Purity Phase
HY-P990093 Stapokibart Inhibitor 99.37% Phase 4
HY-P990748 Lunsekimig Inhibitor 99.00% Phase 3
HY-P99496 Cendakimab Inhibitor 99.96% Phase 3
HY-P990090 Rademikibart Inhibitor 99.13% Phase 3
HY-P991515 TQH-2722 Inhibitor / Phase 3
HY-P99870 Eblasakimab ≥99.0% Phase 2
HY-P990741 Galvokimig 98.74% Phase 2
HY-P991266 SM-17 Inhibitor 96.98% Phase 2
HY-P99439 Anrukinzumab Inhibitor 98.64% Phase 2
HY-P991729 Zumilokibart Inhibitor 95.70% Phase 2
HY-P99883 Romilkimab Inhibitor 99.01% Phase 2
HY-P99846 Dectrekumab / Phase 2
HY-P990594 GSK-679586 Inhibitor / Phase 2
HY-P991633 TQC2938 Inhibitor / Phase 2
HY-P99417 Abrezekimab Inhibitor 95.00% Phase 1
HY-P991258 CNTO-5825 98.18% Phase 1
HY-P990602 IMA-026 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (45)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126360 Oxazolone 98.0% Unkown
HY-P2797A Chitinase, Streptomyces griseus / Unkown
HY-N6013 Aloin (mixture of A&B) 99.36% Unkown
HY-P1848 Pep-1 (uncapped) 99.89% Unkown
HY-145551 Atinvicitinib Inhibitor 98.62% Unkown
HY-P2797 Chitinase, Serratia marcescens / Unkown
HY-144683A PF-07038124 hydrochloride Inhibitor 99.26% Unkown
HY-207120 TSLP-IN-1 Inhibitor 99.67% Unkown
HY-162248 JAK1/2-IN-1 Inhibitor 98.36% Unkown
HY-206870 BP79 Inhibitor / Unkown
HY-125019 iJak-381 Inhibitor 99.86% Unkown
HY-P11287A DOTA-Pep-1L TFA Ligand 98.60% Unkown
HY-110295 SPL-334 Inhibitor 99.6% Unkown
HY-158990 GE1111 95.73% Unkown
HY-181006 TSLP modulator-1 Inhibitor 99.61% Unkown
HY-P10292 NOTA-Pep-1L 98.60% Unkown
HY-P11147 IL13Rα2 D1 Inhibitor 99.17% Unkown
HY-144684 PDE4-IN-8 Inhibitor / Unkown
HY-165484 AVP-13358 Inhibitor / Unkown
HY-172806 PARP14 inhibitor 1 Inhibitor / Unkown
HY-175650 STAT6-IN-9 Inhibitor 98.11% Unkown
HY-175876 ADAM17-IN-1 Inhibitor / Unkown
HY-183548 XW-17 Ligand / Unkown
HY-184915 APH003 / Unkown
HY-P11122 MSP-1 P2 Activator / Unkown
HY-P11287 DOTA-Pep-1L Ligand / Unkown
HY-P2797B Chitinase / Unkown
HY-P2797C Chitinase,Trichoderma viride / Unkown
HY-RS06685 IL13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06686 Il13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06687 Il13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06688 IL13RA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06689 IL13RA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W109107 GED 0507-34-Levo / Unkown
HY-124613 Pyrazinib Inhibitor / Unkown
HY-174637 Human IL13RA2 mRNA / Unkown
HY-174638 Human IL13RA1 mRNA / Unkown
HY-174639 Human IL13 mRNA / Unkown
HY-187160 IL-4-IN-2 Inhibitor / Unkown
HY-N3989 Haplopine 99.49% Unkown
HY-N6013R Aloin (mixture of A&B) (Standard) / Unkown
HY-RS18438 Il13ra2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19279 Il13ra1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24920 Il13ra2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25769 Il13ra1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990121 Anti-Mouse IL-4 Antibody (11B11) Inhibitor 97.67% Unkown
HY-P991162 Tilrekimig Inhibitor 97.00% Unkown
HY-P990735 Donzakimig 98.67% Unkown
HY-P990699 Riltovetbart 99% Unkown
HY-P991150 Ompekimig Inhibitor / Unkown
HY-P992034 APG808 Inhibitor / Unkown
HY-P992132 Solaprubart Inhibitor 99.59% Unkown
HY-P990442 Anti-IL-13 Antibody (CNTO 607) Inhibitor / Unkown
HY-P991594 Anti-IL-13 Antibody (C836) Inhibitor 97.20% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il13 NCBI NCBI:3596