Pkm - pyruvate kinase, muscle Gene

Also Known as Pk3; Pk-2; Pk-3; Pkm2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18746

About Pkm

Chromosome 9: 59,563,651-59,586,658 forward strand.GRCm39:CM001002.3

This gene has 11 transcripts (splice variants), 312 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in duodenum adult (RPKM 494.4), mammary gland adult (RPKM 485.2) and 27 other tissues.

Summary

Enables mRNA binding activity and Pyruvate Kinase activity. Involved in positive regulation of cytoplasmic translation. Acts upstream of or within glycolytic process. Located in cilium; photoreceptor inner segment; and rough endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PKM (Pyruvate Kinase M1/2). [provided by Alliance of Genome Resources, Apr 2022]

Pkm Products (10)

mRNA Protein Name
NM_001378869.1 NP_001365798.1 pyruvate kinase PKM isoform M2
NM_001378870.1 NP_001365799.1 pyruvate kinase PKM isoform M2
NM_011099.4 NP_035229.2 pyruvate kinase PKM isoform M2
NM_001378871.1 NP_001365800.1 pyruvate kinase PKM isoform 3
NM_001378866.1 NP_001365795.1 pyruvate kinase PKM isoform M1
NM_001378868.1 NP_001365797.1 pyruvate kinase PKM isoform M2
NM_001378872.1 NP_001365801.1 pyruvate kinase PKM isoform 4
NM_001253883.2 NP_001240812.1 pyruvate kinase PKM isoform M1
NM_001405491.1 NP_001392420.1 pyruvate kinase PKM isoform M1
NM_001378867.1 NP_001365796.1 pyruvate kinase PKM isoform M1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA binding IDA
IDA: Inferred from direct assay
28575669 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17500595 MGI
enables pyruvate kinase activity IDA
IDA: Inferred from direct assay
7262549 MGI
Biological Process GO Annotation Evidence References Source
involved in canonical glycolysis IDA
IDA: Inferred from direct assay
28630053 MGI
acts upstream of or within glycolytic process IDA
IDA: Inferred from direct assay
7262549 MGI
involved in glycolytic process IDA
IDA: Inferred from direct assay
7262549 MGI
involved in positive regulation of cytoplasmic translation IDA
IDA: Inferred from direct assay
28575669 MGI
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
16687649 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
25565206 MGI
located in rough endoplasmic reticulum IDA
IDA: Inferred from direct assay
28575669 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pkm Protein Structure

Pyruvate_Kinase

Pyruvate_Kinase: cd00288 (41 - 529)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 531 a.a.
Protein Preferred Names Protein Names

pyruvate kinase PKM

  • pyruvate kinase 3

  • pyruvate kinase isozymes M1/M2

  • pyruvate kinase muscle isozyme

  • threonine-protein kinase PKM2

  • tyrosine-protein kinase PKM2

Pkm Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Pkm P52480 Pou5f1 Mus musculus P20263
Confocal
18191611
Intra
Pkm P52480 Pou5f1 Mus musculus P20263
Pull Down
18191611
Cross
Pkm P52480 P04156-PRO_0000025675 Homo sapiens P04156-PRO_0000025675
Affinity Chrom
24390569
Cross
Pkm P52480 P04156-PRO_0000025675 Homo sapiens P04156-PRO_0000025675
Anti Bait CoIP
24390569
Cross
Pkm P52480 polg_hcvbk Hepatitis C virus P26663
Pull Down
18519040
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Pkm Proteins

Cat. No. Product Name Accession Purity
HY-P72053 PKM2 Protein, Mouse (sf9, His, solution) P52480 (M1-P531) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74629 PKM2 Protein, Mouse (sf9, His) P52480 (P2-P531) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0404A Benserazide hydrochloride Inhibitor 99.68% Yes
HY-B0404AR Benserazide hydrochloride (Standard) Inhibitor 99.89% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-121275 Benserazide Inhibitor 98.43% Phase 4
HY-155785 MTP / Phase 4
HY-P1284A ZIP TFA Inhibitor / Phase 4

Pre-clinical Phase

Bioactive Molecules (59)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0822 Shikonin Inhibitor 99.80% Unkown
HY-18657 TEPP-46 Activator 99.93% Unkown
HY-103617 PKM2-IN-1 Inhibitor 99.79% Unkown
HY-19330 DASA-58 Activator 99.57% Unkown
HY-126585 SAICAR 99.57% Unkown
HY-162080 METTL1-WDR4-IN-1 Inhibitor 99.61% Unkown
HY-N7108 7-Hydroxyflavone 99.89% Unkown
HY-P1284 ZIP Inhibitor 98.56% Unkown
HY-157913 PKM2-IN-6 99.95% Unkown
HY-147368 PKM2 activator 2 Activator 99.38% Unkown
HY-167832 PT109 99.20% Unkown
HY-N4185 Licoflavone A 99.95% Unkown
HY-139667 PKM2-IN-3 Inhibitor 99.44% Unkown
HY-N2552 Vitamin K5 hydrochloride 99.25% Unkown
HY-D1456 TEPC466 99.43% Unkown
HY-N3011 Iridin 99.72% Unkown
HY-N7064 Iminostilbene Inhibitor 99.66% Unkown
HY-148324 PKM2 activator 5 Activator 96.03% Unkown
HY-148615 NPD10084 Inhibitor 99.69% Unkown
HY-155850 CIAC001 Inhibitor 99.70% Unkown
HY-W587878 Thujopsene 86.31% Unkown
HY-P1399A Pep2m, myristoylated TFA Inhibitor 99.77% Unkown
HY-126585S SAICAR-d3 96.57% Unkown
HY-132215 PF-06284674 Activator 99.69% Unkown
HY-156375 PKM2 activator 6 / Unkown
HY-162080A METTL1-WDR4-IN-1 TFA Inhibitor 99.61% Unkown
HY-179371 LIQ1 Inhibitor 97.40% Unkown
HY-D1876 ZY-2 95.77% Unkown
HY-RS10602 PKM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119874 Alkannin Inhibitor / Unkown
HY-147397 PKM2 activator 3 Activator / Unkown
HY-149275 PKM2/PDK1-IN-1 / Unkown
HY-155216 PKM2 activator 10 Activator / Unkown
HY-155668 HMG-CoA Reductase-IN-1 Inhibitor / Unkown
HY-155849 PKM2-IN-4 Inhibitor / Unkown
HY-161519 PKM2 activator 7 Activator / Unkown
HY-168882 PKM2 modulator 1 / Unkown
HY-168883 PKM2 modulator 2 / Unkown
HY-169567 PKM2-IN-9 Inhibitor / Unkown
HY-170577 PKM2-IN-8 / Unkown
HY-172881 PKM2-IN-10 Inhibitor / Unkown
HY-178441 PKM2-IN-11 / Unkown
HY-178748 PKM2-IN-12 / Unkown
HY-180523 PKM2-IN-13 / Unkown
HY-180795 PKM2 activator 11 / Unkown
HY-182037 Multi-target kinase-IN-9 Inhibitor / Unkown
HY-183765 PARP1/PKM2-IN-1 Inhibitor / Unkown
HY-B0404AS Benserazide-d3 hydrochloride Inhibitor / Unkown
HY-B1814 Vitamin K5 / Unkown
HY-D1877 ZY-1 98.91% Unkown
HY-P1399 Pep2m, myristoylated Inhibitor / Unkown
HY-RS10603 Pkm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10604 Pkm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W753956 Iminostilbene-d10 / Unkown
HY-148313 PKM2 activator 4 Activator / Unkown
HY-162071 PKM2-IN-5 Inhibitor / Unkown
HY-168995 BAR-072 Inhibitor / Unkown
HY-169883 PKM2-IN-7 Inhibitor / Unkown
HY-180796 PKM2 agonist-1 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pkm NCBI NCBI:5315