2. Gene
  3. Pkm - pyruvate kinase, muscle Gene

Pkm - pyruvate kinase, muscle Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pk3; Pk-2; Pk-3; Pkm2

Gene ID: 18746 | Gene type: protein coding

About Pkm

Chromosome 9: 59,563,651-59,586,658 forward strand.GRCm39:CM001002.3

This gene has 11 transcripts (splice variants), 312 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in duodenum adult (RPKM 494.4), mammary gland adult (RPKM 485.2) and 27 other tissues.

Summary

Enables mRNA binding activity and Pyruvate Kinase activity. Involved in positive regulation of cytoplasmic translation. Acts upstream of or within glycolytic process. Located in cilium; photoreceptor inner segment; and rough endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PKM (Pyruvate Kinase M1/2). [provided by Alliance of Genome Resources, Apr 2022]

Pkm Products(10)

mRNA Protein Name
NM_001378869.1 NP_001365798.1 pyruvate kinase PKM isoform M2
NM_001378870.1 NP_001365799.1 pyruvate kinase PKM isoform M2
NM_011099.4 NP_035229.2 pyruvate kinase PKM isoform M2
NM_001378871.1 NP_001365800.1 pyruvate kinase PKM isoform 3
NM_001378866.1 NP_001365795.1 pyruvate kinase PKM isoform M1
NM_001378868.1 NP_001365797.1 pyruvate kinase PKM isoform M2
NM_001378872.1 NP_001365801.1 pyruvate kinase PKM isoform 4
NM_001253883.2 NP_001240812.1 pyruvate kinase PKM isoform M1
NM_001405491.1 NP_001392420.1 pyruvate kinase PKM isoform M1
NM_001378867.1 NP_001365796.1 pyruvate kinase PKM isoform M1

Pkm Protein Structure

Pyruvate_Kinase

Pyruvate_Kinase: cd00288 (41 - 529)

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  • 531 a.a.
Protein Preferred Names Protein Names

pyruvate kinase PKM

pyruvate kinase 3

pyruvate kinase isozymes M1/M2

pyruvate kinase muscle isozyme

threonine-protein kinase PKM2

tyrosine-protein kinase PKM2

Recombinant Pkm Proteins

Cat. No. Product Name Accession Purity
HY-P72053 PKM2 Protein, Mouse (Baculovirus, His-Myc) P52480 (M1-P531) ≥95%
HY-P74629 PKM2 Protein, Mouse (sf9, His) P52480 (P2-P531) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-P1284 ZIP Inhibitor 98.03% Phase 4
HY-P1284A ZIP TFA Inhibitor / Phase 4
Pre-clinical Phase
Bioactive Molecules (30)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0822 Shikonin Inhibitor 99.80% Unkown
HY-18657 TEPP-46 Activator 99.65% Unkown
HY-103617 PKM2-IN-1 Inhibitor 99.61% Unkown
HY-19330 DASA-58 Activator 99.67% Unkown
HY-126585 SAICAR 99.36% Unkown
HY-147368 PKM2 activator 2 Activator 99.48% Unkown
HY-D1456 TEPC466 99.43% Unkown
HY-148324 PKM2 activator 5 Activator 96.24% Unkown
HY-D1876 ZY-2 / Unkown
HY-P1399A Pep2m, myristoylated TFA Inhibitor 99.77% Unkown
HY-119874 Alkannin Inhibitor / Unkown
HY-126585S SAICAR-d1 / Unkown
HY-139667 PKM2-IN-3 Inhibitor / Unkown
HY-147397 PKM2 activator 3 Activator / Unkown
HY-148313 PKM2 activator 4 Activator / Unkown
HY-148615 NPD10084 Inhibitor / Unkown
HY-149275 PKM2/PDK1-IN-1 / Unkown
HY-155668 HMG-CoA Reductase-IN-1 Inhibitor / Unkown
HY-155785 MTP / Unkown
HY-155849 PKM2-IN-4 Inhibitor / Unkown
HY-155850 CIAC001 Inhibitor / Unkown
HY-156375 PKM2 activator 6 / Unkown
HY-157913 PKM2-IN-6 / Unkown
HY-B1814 Vitamin K5 Inhibitor / Unkown
HY-D1877 ZY-1 98.91% Unkown
HY-P1399 Pep2m, myristoylated Inhibitor / Unkown
HY-RS10602 PKM Human Pre-designed siRNA Set A / Unkown
HY-RS10603 Pkm Mouse Pre-designed siRNA Set A / Unkown
HY-RS10604 Pkm Rat Pre-designed siRNA Set A / Unkown
HY-121275 Benserazide Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pkm NCBI NCBI:5315