Wee1 - WEE 1 homolog 1 (S. pombe) Gene

Also Known as Wee1A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22390

About Wee1

Chromosome 7: 109,721,253-109,742,493 forward strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant), 227 orthologues, 8 paralogues and is associated with 19 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 12.3), placenta adult (RPKM 11.4) and 27 other tissues.

Summary

Enables protein kinase activity. Acts upstream of or within several processes, including establishment of cell polarity; neuron projection morphogenesis; and peptidyl-tyrosine phosphorylation. Located in cytoplasm. Is expressed in several structures, including 8-cell stage embryo; alimentary system; blastocyst; brain ventricular layer; and inferior colliculus. Orthologous to human Wee1 (Wee1 G2 checkpoint kinase). [provided by Alliance of Genome Resources, Apr 2022]

Wee1 Products (2)

mRNA Protein Name
NM_001355058.1 NP_001341987.1 wee1-like protein kinase isoform 2
NM_009516.3 NP_033542.2 wee1-like protein kinase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20026642 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
7551544 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
20026642 MGI
acts upstream of or within microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
20026642 MGI
acts upstream of or within neuron projection morphogenesis IGI
IGI: Inferred from genetic interaction
20026642 MGI
acts upstream of or within neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
20026642 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
15459478 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
7551544 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15459478 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Wee1 Protein Structure

PTKc_Wee1a

PTKc_Wee1a: cd14138 (291 - 566)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 646 a.a.
Protein Preferred Names Protein Names

wee1-like protein kinase

  • WEE1 tyrosine kinase

  • wee1A kinase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-132295 Azenosertib Inhibitor 99.96% Phase 3
HY-10993 Adavosertib Inhibitor 99.96% Phase 2
HY-145817A lunresertib Inhibitor 99.97% Phase 2
HY-147054 Zedoresertib Inhibitor 99.85% Phase 2
HY-175749 BMS-986463 Degrader 98.63% Phase 1
HY-182906 XL495 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (72)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13925 PD0166285 Inhibitor 99.46% Unkown
HY-N0819 Raddeanin A Inhibitor 98.68% Unkown
HY-18961 PD 407824 Inhibitor 99.00% Unkown
HY-122113 PD173952 Inhibitor 99.58% Unkown
HY-W1135319 SB-405483 99.33% Unkown
HY-133618 Pomalidomide-C3-adavosertib Degrader 99.84% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-147312 GSK-1520489A Inhibitor 99.83% Unkown
HY-108343 WEE1-IN-4 Inhibitor 99.70% Unkown
HY-103029 Bosutinib isomer Inhibitor 98.47% Unkown
HY-148062 RSS0680 99.85% Unkown
HY-145817 (Rac)-lunresertib Inhibitor 99.72% Unkown
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% Unkown
HY-173320 HEMTAC WEE1 degrader-1 Degrader 99.78% Unkown
HY-144999 LEB-03-146 98.08% Unkown
HY-138239 WEE1-IN-3 Inhibitor 98.33% Unkown
HY-168654 WEE1 degrader 1 Degrader 99.74% Unkown
HY-145664 Myt1-IN-1 Inhibitor 98.97% Unkown
HY-161880 WEE1-IN-10 Inhibitor / Unkown
HY-163697 WEE1-IN-7 Inhibitor 99.70% Unkown
HY-145666 Myt1-IN-3 Inhibitor 99.14% Unkown
HY-163490 PKMYT1-IN-1 Inhibitor 99.24% Unkown
HY-W070306 PDK1-IN-1 Inhibitor 99.95% Unkown
HY-145817B (R)-lunresertib Inhibitor 99.72% Unkown
HY-169946 WEE1/PKMYT1-IN-1 Inhibitor 98.84% Unkown
HY-180485 PROTAC D16-M1P2 Degrader / Unkown
HY-145665 Myt1-IN-2 Inhibitor / Unkown
HY-176363 Adavosertib-C3-NH-Boc Inhibitor / Unkown
HY-178190 WEE1-IN-13 Inhibitor / Unkown
HY-163491 PKMYT1-IN-2 Inhibitor / Unkown
HY-178150 WEE1-IN-14 Inhibitor / Unkown
HY-176283 Tubulin/LSD1-IN-1 Inhibitor / Unkown
HY-160948 DB07006 Inhibitor / Unkown
HY-143342 LEB-03-144 / Unkown
HY-182790 BAA-065 Inhibitor / Unkown
HY-161871 WEE1-IN-8 Inhibitor / Unkown
HY-143343 LEB-03-153 / Unkown
HY-208742 ZNL-02-096 Degrader / Unkown
HY-180484 PKMYT1-IN-12 Inhibitor / Unkown
HY-162849 PKMYT1-IN-3 Inhibitor / Unkown
HY-179272 Wee1/HDAC-IN-1 Inhibitor / Unkown
HY-161879 WEE1-IN-9 Inhibitor / Unkown
HY-187562 PKMYT1-IN-15 Inhibitor / Unkown
HY-168180 WEE1-IN-11 Inhibitor / Unkown
HY-172759 PKMYT1-IN-9 Inhibitor / Unkown
HY-172807 p38α-IN-9 Inhibitor / Unkown
HY-183278 APO-50815 Inhibitor / Unkown
HY-174448 WEE1-IN-12 Inhibitor / Unkown
HY-133703A i-AZD1775 TFA Inhibitor / Unkown
HY-133703 AZD1775-C3-NH2 Inhibitor / Unkown
HY-183547 WEE1/PKMYT1-IN-4 Inhibitor / Unkown
HY-175817 PKMYT1-IN-10 Inhibitor / Unkown
HY-182433 CJM061 Inhibitor / Unkown
HY-175261 DHI1 Inhibitor / Unkown
HY-143340 LEB-03-145 / Unkown
HY-175819 PD-166285 Inhibitor / Unkown
HY-169946A WEE1/PKMYT1-IN-2 Inhibitor / Unkown
HY-160530 WEE1-IN-6 Inhibitor / Unkown
HY-182791 BAA-009 Inhibitor / Unkown
HY-176957 PKMYT1-IN-11 Inhibitor / Unkown
HY-180893 XH-30 Inhibitor / Unkown
HY-169946B WEE1/PKMYT1-IN-3 Inhibitor / Unkown
HY-13925A PD0166285 dihydrochloride Inhibitor / Unkown
HY-157443 Myt1-IN-4 Inhibitor / Unkown
HY-188057 Sirusertib Inhibitor / Unkown
HY-162986 PKMYT1-IN-4 Inhibitor / Unkown
HY-162988 Myt1-IN-5 Inhibitor / Unkown
HY-184405 PKMYT1-IN-14 Inhibitor / Unkown
HY-176853 Myt1-IN-6 Inhibitor / Unkown
HY-162987 PKMYT1-IN-6 Inhibitor / Unkown
HY-N0819R Raddeanin A (Standard) / Unkown
HY-159937 PKMYT1-IN-7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wee1 NCBI NCBI:7465