1. Gene
  2. ERBB2 - erb-b2 receptor tyrosine kinase 2 Gene

ERBB2 - erb-b2 receptor tyrosine kinase 2 Gene

Rattus norvegicus

Also known as neu; HER2/neu

Gene ID: 24337 | Gene type: protein coding

About ERBB2

Primary_assembly 10: 83,411,313-83,435,078 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 200 orthologues, 54 paralogues and is associated with 83 phenotypes. Biased expression in Kidney (RPKM 121.3), Lung (RPKM 59.5) and 8 other tissues.

Summary

Enables HSP90 protein binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of intracellular signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral loop; and microvillus. Biomarker of congestive heart failure and median neuropathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma; reproductive organ Cancer (multiple); and urinary bladder Cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

ERBB2 Products(1)

mRNA Protein Name
NM_017003.2 NP_058699.2 receptor tyrosine-protein kinase erbB-2 precursor

ERBB2 Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (54 - 176)

Furin-like

Furin-like: pfam00757 (192 - 341)

Recep_L_domain

Recep_L_domain: pfam01030 (369 - 485)

GF_recep_IV

GF_recep_IV: pfam14843 (513 - 646)

TM_ErbB2

TM_ErbB2: cd12094 (644 - 687)

PTKc_HER2

PTKc_HER2: cd05109 (715 - 993)

PHA03247

PHA03247: cl33720 (1036 - 1218)

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  • 1259 a.a.
Protein Preferred Names Protein Names

receptor tyrosine-protein kinase erbB-2

Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)

C-erbB-2

NEU proto-oncogene

epidermal growth factor receptor-related protein

p185erbB2

p185neu

proto-oncogene NEU

proto-oncogene c-ErbB-2

receptor tyrosine-protein kinase erbB-2-like

v-erb-b2 avian erythroblastic leukemia viral oncogene 2

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Recombinant ERBB2 Proteins

Cat. No. Product Name Accession Purity
HY-P72626 HER2/CD340 Protein, Rat (His) P06494 (A67-V323) ≥95%
HY-P73097 HER2/CD340 Protein, Rat (HEK293) Q8K3F9 (M4-T656) ≥95%
HY-P74895 HER2/CD340 Protein, Rat (HEK293, His) AAH61863 (M4-T656) ≥95%
HY-P74896 HER2/CD340 Protein, Rat (HEK293, Fc) AAH61863 (M4-T656) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens ERBB2 NCBI NCBI:2064
Canis familiaris ERBB2 NCBI NCBI:403883
Macaca fascicularis ERBB2 NCBI NCBI:102146608
Mus musculus ERBB2 NCBI NCBI:13866
Macaca mulatta ERBB2 NCBI NCBI:697573