ERBB2 - erb-b2 receptor tyrosine kinase 2 Gene

Also Known as neu; HER2/neu

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24337

About ERBB2

Primary_assembly 10: 83,411,313-83,435,078 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 200 orthologues, 54 paralogues and is associated with 83 phenotypes. Biased expression in Kidney (RPKM 121.3), Lung (RPKM 59.5) and 8 other tissues.

Summary

Enables HSP90 protein binding activity; protein tyrosine kinase activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of intracellular signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral loop; and microvillus. Biomarker of congestive heart failure and median neuropathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma; reproductive organ Cancer (multiple); and urinary bladder Cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

ERBB2 Products (1)

mRNA Protein Name
NM_017003.2 NP_058699.2 receptor tyrosine-protein kinase erbB-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp90 protein binding IPI
IPI: Inferred from physical interaction
15671027 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9271418 RGD
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
1359541 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
16168116 RGD
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
15671027 RGD
Biological Process GO Annotation Evidence References Source
involved in ERBB2-ERBB4 signaling pathway IDA
IDA: Inferred from direct assay
19632177 RGD
involved in axon regeneration IMP
IMP: Inferred from mutant phenotype
23437108 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
30813222 RGD
involved in estrous cycle IMP
IMP: Inferred from mutant phenotype
11956173 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
21186272 RGD
involved in glial cell differentiation IGI
IGI: Inferred from genetic interaction
12853432 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
12454858 RGD
involved in mammary gland involution IEP
IEP: Inferred from expression pattern
10653587 RGD
involved in multicellular organismal response to stress IEP
IEP: Inferred from expression pattern
27133902 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12673197 RGD
involved in peripheral nervous system development IMP
IMP: Inferred from mutant phenotype
15496447 RGD
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
16168116 RGD
involved in positive regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
12673197 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9271418 RGD
involved in positive regulation of membrane permeability IMP
IMP: Inferred from mutant phenotype
30813222 RGD
involved in positive regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
16859650 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
16168116 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
1359541 RGD
involved in response to axon injury IDA
IDA: Inferred from direct assay
15800203 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
27133902 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
26892146 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
17459743 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
27209698 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18184445 RGD
involved in skeletal muscle tissue development IEP
IEP: Inferred from expression pattern
8846777 RGD
involved in sympathetic nervous system development IMP
IMP: Inferred from mutant phenotype
15496447 RGD
involved in tongue development IEP
IEP: Inferred from expression pattern
10908606 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15499570 RGD
located in basal plasma membrane IDA
IDA: Inferred from direct assay
15499570 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15499570 RGD
located in lateral loop IDA
IDA: Inferred from direct assay
15800203 RGD
located in microvillus IDA
IDA: Inferred from direct assay
15800203 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
16859650 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15800203 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
7589796 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERBB2 Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (54 - 176)

Furin-like

Furin-like: pfam00757 (192 - 341)

Recep_L_domain

Recep_L_domain: pfam01030 (369 - 485)

GF_recep_IV

GF_recep_IV: pfam14843 (513 - 646)

TM_ErbB2

TM_ErbB2: cd12094 (644 - 687)

PTKc_HER2

PTKc_HER2: cd05109 (715 - 993)

PHA03247

PHA03247: cl33720 (1036 - 1218)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1259 a.a.
Protein Preferred Names Protein Names

receptor tyrosine-protein kinase erbB-2

  • Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)

  • C-erbB-2

  • NEU proto-oncogene

  • epidermal growth factor receptor-related protein

  • p185erbB2

  • p185neu

  • proto-oncogene NEU

  • proto-oncogene c-ErbB-2

  • receptor tyrosine-protein kinase erbB-2-like

  • v-erb-b2 avian erythroblastic leukemia viral oncogene 2

  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Recombinant ERBB2 Proteins

Cat. No. Product Name Accession Purity
HY-P72626 HER2/CD340 Protein, Rat (His) P06494 (A67-V323) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73097 HER2/CD340 Protein, Rat (HEK293) P06494 (T23-T654, with seven additional amino acids (ALEVLFQ) at the C-terminus) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P74895 HER2/CD340 Protein, Rat (HEK293, His) AAH61863 (M4-T656) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74896 HER2/CD340 Protein, Rat (HEK293, Fc) AAH61863 (T26-T656) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50898 Lapatinib 99.83% Yes
HY-13272 Dacomitinib 99.74% Yes
HY-50898A Lapatinib ditosylate 99.98% Yes
HY-50898B Lapatinib ditosylate monohydrate 99.99% Yes
HY-16069A Tucatinib hemiethanolate Inhibitor 98.82% Yes
HY-50898C Lapatinib tosylate / Unkown

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-13050 Sapitinib Inhibitor 99.93% Phase 2
HY-10367 Canertinib Inhibitor 99.74% Phase 2
HY-32718 Pelitinib Inhibitor 99.13% Phase 2
HY-10045 AEE788 98.39% Phase 2
HY-14674 CP-724714 98.72% Phase 2
HY-103443 HKI-357 Inhibitor 99.24% Phase 1
HY-116437 Selatinib Inhibitor 98.56% Phase 1
HY-10346 AV-412 Inhibitor 99.17% Phase 1
HY-135366 HPN-01 Inhibitor 98.61% Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P990697 Anvatabart Inhibitor 98.15% Phase 3
HY-P991524 MM-111 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (57)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168438 ERBB agonist-1 99.16% Unkown
HY-112411 PD 174265 98.35% Unkown
HY-13896 PD168393 98.01% Unkown
HY-18609 PD158780 Inhibitor 99.47% Unkown
HY-15375 Allitinib Inhibitor 98.88% Unkown
HY-10322 Falnidamol Inhibitor 99.41% Unkown
HY-10367A Canertinib dihydrochloride Inhibitor 99.68% Unkown
HY-20878 Tyrphostin AG 879 99.26% Unkown
HY-10325 CL-387785 99.31% Unkown
HY-15844 AG-825 98.13% Unkown
HY-13427 Allitinib tosylate Inhibitor 99.54% Unkown
HY-P4082 ErbB-2-binding peptide-1 Ligand 99.52% Unkown
HY-150023 BI-1622 Inhibitor 98.02% Unkown
HY-103440 EGFR/ErbB-2/ErbB-4 inhibitor-3 Inhibitor 96.78% Unkown
HY-123035 Gamendazole Inhibitor 99.44% Unkown
HY-101042 AG-494 Inhibitor 98.69% Unkown
HY-112420 EGFR/ErbB-2-IN-2 Inhibitor 99.45% Unkown
HY-103441 JNJ28871063 hydrochloride Inhibitor 98.36% Unkown
HY-50898S Lapatinib-d4 99.02% Unkown
HY-N1166 Tephrosin 98.02% Unkown
HY-RS04466 ERBB2 Human Pre-designed siRNA Set A / Unkown
HY-100499 Tyrphostin AG 528 Inhibitor 98.0% Unkown
HY-103439 GW583340 dihydrochloride Inhibitor / Unkown
HY-10346A AV-412 free base Inhibitor 98.10% Unkown
HY-13272S2 Dacomitinib-d10 dihydrochloride ≥95.0% Unkown
HY-E70715 ERBB2 775YVMA776 Recombinant Human Active Protein Kinase / Unkown
HY-123726 ErbB-1/ErbB-2 tyrosine kinase-IN-1 / Unkown
HY-147407 Imbotolimod Inhibitor / Unkown
HY-103439A GW583340 Inhibitor / Unkown
HY-118900 CP-654577 / Unkown
HY-129288 GW837016X Inhibitor / Unkown
HY-13050A Sapitinib fumarate Inhibitor / Unkown
HY-13272S3 Dacomitinib-d10 / Unkown
HY-137028 2′-Thioadenosine Inhibitor / Unkown
HY-156639 EGFR/ErbB-2 inhibitor-1 Inhibitor / Unkown
HY-168577 KRAS G12D inhibitor 25 / Unkown
HY-175809 SRT6 Inhibitor / Unkown
HY-177989 ER121 Inhibitor 98.52% Unkown
HY-184940 BTK-IN-50 Inhibitor / Unkown
HY-50898S1 Lapatinib-d7 dihydrochloride / Unkown
HY-50898S2 Lapatinib-d5 / Unkown
HY-50898S3 Lapatinib-d4-1 / Unkown
HY-50898S5 Lapatinib-13C,d7 / Unkown
HY-P10981 ErbB2 peptide Ligand / Unkown
HY-RS04467 Erbb2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04468 ERBB2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W008914 (E/Z)-CP-724714 Inhibitor / Unkown
HY-W740576 7-Descarbamoyl-17-amino geldanamycin / Unkown
HY-W777297 Lapatinib-13C2,15N Ditosylate / Unkown
HY-10325R CL-387785 (Standard) / Unkown
HY-103443A HKI-357 dimaleate Inhibitor / Unkown
HY-160068 2-2(t) aptamer sodium Chemical 99.28% Unkown
HY-174671 Human HBEGF mRNA / Unkown
HY-178740 GI261520A Inhibitor / Unkown
HY-32718S Pelitinib-d6 / Unkown
HY-50898CS Lapatinib-d4 tosylate / Unkown
HY-50898S4 Lapatinib-d7 / Unkown
Inhibitory Antibodies (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99558 Timigutuzumab Inhibitor 97.53% Unkown
HY-P990909 Calotatug 98% Unkown
HY-P990978 Caxmotabart 96.56% Unkown
HY-P990695 Lunaxafusp (His Tag) Inhibitor / Unkown
HY-P990972 Azerutamig / Unkown
HY-P992107 Dulpatatug Inhibitor 99.09% Unkown
HY-P991243 MP-RM-1 Inhibitor 96.29% Unkown
HY-P991979 Erbicin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ERBB2 NCBI NCBI:2064