Irf3 - interferon regulatory factor 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 292892

Summary

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; promoter-specific chromatin binding activity; and protein homodimerization activity. Involved in cellular response to exogenous dsRNA; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of cytokine production. Predicted to be located in cytosol and mitochondrion. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Irf3 Products (1)

mRNA Protein Name
NM_001006969.1 NP_001006970.1 interferon regulatory factor 3

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to exogenous dsRNA IEP
IEP: Inferred from expression pattern
18223009 RGD
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
20670634 RGD
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
20670634 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon regulatory factor 3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-176426 Subquinocin 99.83% Phase 4
HY-10249 GSK-690693 99.03% Phase 1

Pre-clinical Phase

Bioactive Molecules (71)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12326A c-di-AMP disodium Agonist 99.14% Unkown
HY-160225 ISD sodium 98.02% Unkown
HY-113469 Cyclic GMP 99.77% Unkown
HY-P1680 Astin C Inhibitor 99.47% Unkown
HY-P1934 Cyclo(Phe-Pro) Inhibitor 99.22% Unkown
HY-101950 KIN1148 Inhibitor 98.0% Unkown
HY-P11072 IRF5-CPP5 Inhibitor 99.23% Unkown
HY-113469A Cyclic GMP sodium 99.89% Unkown
HY-139056 SU0268 Inhibitor 99.96% Unkown
HY-12326B c-di-AMP diammonium Agonist 99.01% Unkown
HY-152956 STING agonist-23 Agonist 99.33% Unkown
HY-W140974 SN-001 Inhibitor 99.22% Unkown
HY-156449 STING-IN-7 Inhibitor 98.29% Unkown
HY-112951 ChX710 99.91% Unkown
HY-123805 KIN1400 98.1% Unkown
HY-D0162 Malachite green hemioxalate 98.0% Unkown
HY-124652 TBK1/IKKε-IN-4 Inhibitor 99.42% Unkown
HY-173425 STING-IN-15 Inhibitor 99.04% Unkown
HY-17663 KMR-206 98.86% Unkown
HY-164278 diABZI-V/C-Mal 99.28% Unkown
HY-12326 c-di-AMP Agonist 99.29% Unkown
HY-152959 STING agonist-26 Agonist 99.56% Unkown
HY-126113 KIN101 99.44% Unkown
HY-168034 diABZI-4 98.33% Unkown
HY-177338 STING agonist-45 Agonist 99.10% Unkown
HY-113469B Cyclic GMP TBAOH / Unkown
HY-181526 Sim-9 Inhibitor / Unkown
HY-W654000 Cyclic GMP-13C,15N2 98.81% Unkown
HY-138646 Poly(deoxyadenylic-thymidylic) acid sodium / Unkown
HY-160222 HSV-60mer sodium 98.11% Unkown
HY-160225F Biotin-labeled ISD sodium / Unkown
HY-162133 MSA-2-Pt / Unkown
HY-173462 TBK1-IN-2 Inhibitor 98.19% Unkown
HY-175714 STING agonist-46 Agonist 98.63% Unkown
HY-176192 SMU-14a Inhibitor / Unkown
HY-178049 UM-259 Inhibitor / Unkown
HY-W767865 Cyclic GMP sodium-13C5 99.03% Unkown
HY-148606 STING modulator-3 Inhibitor / Unkown
HY-148645 STING modulator-4 Modulator / Unkown
HY-152957 STING agonist-24 Agonist / Unkown
HY-152958 STING agonist-25 Agonist / Unkown
HY-152961 STING agonist-28 Agonist / Unkown
HY-158036 PROTAC STING Degrader-2 / Unkown
HY-162844 CDN-3 Activator / Unkown
HY-162963 DN203316 / Unkown
HY-162966 MS7829 Activator / Unkown
HY-162967 MS8588 Degrader / Unkown
HY-173399 hSTING activator-1 / Unkown
HY-174136 STING Degrader-2 / Unkown
HY-174308 ZSA-215 Agonist / Unkown
HY-178047 UM-242 Inhibitor / Unkown
HY-178690 MyD88-IN-4 Inhibitor / Unkown
HY-178915 ITA-5 Inhibitor / Unkown
HY-178916 ITA-9 Inhibitor / Unkown
HY-178951 STING-IN-17 Inhibitor / Unkown
HY-180120 UM-203 / Unkown
HY-180674 LA24 Agonist / Unkown
HY-181484 STING agonist-50 / Unkown
HY-182923 UM-200 Inhibitor / Unkown
HY-183537 KSI-028 Inhibitor / Unkown
HY-183607 SMU-3k / Unkown
HY-184200 Enpp-1-IN-32 / Unkown
HY-N18197 Norkurarinol / Unkown
HY-RS06907 IRF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-149724 Anti-inflammatory agent 65 Inhibitor / Unkown
HY-N10175 Berkeleyacetal C / Unkown
HY-N3548 Catalpalactone Inhibitor / Unkown
HY-N8107 Matairesinol monoglucoside 99.42% Unkown
HY-RS16587 Irf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23022 Irf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W682115 Poly(C) Activator / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991989 MRG004A Antibody 95.44% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irf3 NCBI NCBI:3661