Fos - Fos proto-oncogene, AP-1 transcription factor subunit Gene

Also Known as c-fos

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 314322

Summary

Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including conditioned taste aversion; positive regulation of pri-miRNA transcription by RNA polymerase II; and response to steroid hormone. Located in membrane; neuron projection; and nucleus. Biomarker of congestive heart failure; glomerulonephritis; and hypertension. Orthologous to human FOS (Fos proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Fos Products (1)

mRNA Protein Name
NM_022197.2 NP_071533.1 protein c-Fos

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
2105492 RGD
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
10830307 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
2105492 RGD
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
29330744 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7665092 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
2105492 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9369238 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10830307 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to epidermal growth factor stimulus IEP
IEP: Inferred from expression pattern
8603605 RGD
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
11460264 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
8593588 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
8603605 RGD
involved in cellular response to phorbol 13-acetate 12-myristate IEP
IEP: Inferred from expression pattern
8603605 RGD
involved in cellular response to prolactin IEP
IEP: Inferred from expression pattern
8584023 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in cellular response to zinc ion starvation IEP
IEP: Inferred from expression pattern
21893222 RGD
involved in cerebral cortex development IMP
IMP: Inferred from mutant phenotype
32385110 RGD
involved in conditioned taste aversion IEP
IEP: Inferred from expression pattern
18374904 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
12080023 RGD
involved in medium-term memory IMP
IMP: Inferred from mutant phenotype
22532480 RGD
involved in mononuclear cell differentiation IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in myoblast proliferation IEP
IEP: Inferred from expression pattern
2425941 RGD
involved in neural retina development IEP
IEP: Inferred from expression pattern
20589906 RGD
involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
32385110 RGD
involved in positive regulation of miRNA transcription IDA
IDA: Inferred from direct assay
18384814 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
24286756 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
18280640 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
18485334 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
18280640 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
22576626 RGD
involved in response to gravity IEP
IEP: Inferred from expression pattern
17274184 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
17936518 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
20818503 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
11146118 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
11389931 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
15126239 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
10934195 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
12080023 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
21948387 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
11295234 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
12243769 RGD
involved in skeletal muscle cell proliferation IEP
IEP: Inferred from expression pattern
2447874 RGD
involved in transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10830307 RGD
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
32385110 RGD
located in nuclear matrix IDA
IDA: Inferred from direct assay
20053986 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
20053986 RGD
located in nucleus IDA
IDA: Inferred from direct assay
7595148 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein c-Fos

  • FBJ murine osteosarcoma viral oncogene homolog

  • FBJ osteosarcoma oncogene

  • c-fos oncogene

  • proto-oncogene c-FOS

  • proto-oncogene cFOS

  • v-fos FBJ murine osteosarcoma viral oncogene homolog

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113756A Latanoprost acid Agonist 98.77% Unkown
HY-B1052A Lofexidine Agonist 99.08% Unkown
HY-B1052 Lofexidine hydrochloride Agonist 99.72% Unkown
HY-A0116A Trandolaprilate hydrate Inhibitor 97.30% Unkown
HY-A0116 Trandolaprilate Inhibitor 99.42% Unkown
HY-B1052R Lofexidine hydrochloride (Standard) Agonist / Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12270 T-5224 Inhibitor 99.59% Phase 2
HY-100426A Osemozotan hydrochloride Agonist / Phase 2
HY-113726 Nerisopam Agonist / Phase 1

Pre-clinical Phase

Bioactive Molecules (60)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10408 Candidalysin Activator 99.81% Unkown
HY-N0231 Bavachalcone 99.90% Unkown
HY-N2119 Sciadopitysin Inhibitor 99.0% Unkown
HY-N6837 Fructo-​oligosaccharide DP7/GF6 99.94% Unkown
HY-P10927 BRP 99.62% Unkown
HY-N5048 Galloylpaeoniflorin Inhibitor 98.30% Unkown
HY-N0805A Alisol B 99.57% Unkown
HY-165126 Schizophyllan / Unkown
HY-A0299 H-Gly-Pro-Hyp-OH Inhibitor 99.48% Unkown
HY-P10506 CMX-8933 Activator 99.77% Unkown
HY-107621 U0124 98.0% Unkown
HY-169021 JNK-1-IN-3 Inhibitor 98.44% Unkown
HY-59201A A-582941 dihydrochloride 99.78% Unkown
HY-182757 Y1693 Inhibitor 99.91% Unkown
HY-N6836 Fructo-oligosaccharide DP8/GF7 99.76% Unkown
HY-124277 ADM 12 Antagonist 98.86% Unkown
HY-P10927A BRP TFA / Unkown
HY-B1052S Lofexidine-d4 hydrochloride Agonist / Unkown
HY-100839 (RS)-(Tetrazol-5-yl)glycine Agonist 96.53% Unkown
HY-106584 Mosapramine Antagonist 98.58% Unkown
HY-114753 Neboglamine Modulator / Unkown
HY-168895 c-Fos-IN-1 97.24% Unkown
HY-N6835 Fructo-oligosaccharide DP9/GF8 99.83% Unkown
HY-P10405A TAT-D1 peptide acetate Inhibitor / Unkown
HY-RS05032 FOS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16815 Fos Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-106153B E-5842 citrate Ligand / Unkown
HY-107614G 1-Oleoyl lysophosphatidic acid sodium (GMP) Activator / Unkown
HY-113443 12(S)-HPETE Activator / Unkown
HY-113756B rel-Latanoprost acid Agonist / Unkown
HY-116640 Amorphigenin Inhibitor / Unkown
HY-120306 HHL-6 Inhibitor / Unkown
HY-12270S T-5224-d8 / Unkown
HY-131721 14,15-EET-SI Activator / Unkown
HY-15026 ATB 429 / Unkown
HY-168482 NF-κB/MAPK-IN-2 Inhibitor / Unkown
HY-168895A (E,E)-c-Fos-IN-1 / Unkown
HY-169451 Cannabidiolic acid methyl ester Modulator / Unkown
HY-175007 RIPK1-IN-32 Inhibitor / Unkown
HY-176019 Methylcarbamyl PAF C-8 / Unkown
HY-179216 KTT-1 Inhibitor / Unkown
HY-179684 PCC0105005 / Unkown
HY-182504 NRA-0562 / Unkown
HY-59201 A-582941 / Unkown
HY-A0116S1 Trandolaprilate-d6 / Unkown
HY-B1052S1 Lofexidine-d4 Agonist / Unkown
HY-E70684 CDK5/p25NCK Recombinant Human Active Protein Kinase / Unkown
HY-E70685 CDK5/p35NCK Recombinant Human Active Protein Kinase / Unkown
HY-N11775 Eudebeiolide B / Unkown
HY-N1326 Santamarine 98.85% Unkown
HY-N18209 4-Hydroxy-3-butylphthalide / Unkown
HY-N3071 Picrasidine I / Unkown
HY-N6834 Fructo-​oligosaccharide DP10/GF9 98.0% Unkown
HY-P11617 CLP-d2 Inhibitor / Unkown
HY-174682 Human FOS mRNA / Unkown
HY-B1606 Chlorothymol 99.70% Unkown
HY-N7008 Fructo-oligosaccharide DP11/GF10 / Unkown
HY-N7009 Fructo-oligosaccharide DP12/GF11 98.0% Unkown
HY-P10405 TAT-D1 peptide Antagonist / Unkown
HY-RS23255 Fos Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fos NCBI NCBI:2353