Irf3 - interferon regulatory factor 3 Gene

Also Known as IRF-3; C920001K05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54131

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to virus; positive regulation of type I interferon production; and type I interferon signaling pathway. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; negative regulation of macromolecule metabolic process; and regulation of defense response. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Irf3 Products (1)

mRNA Protein Name
NM_016849.4 NP_058545.1 interferon regulatory factor 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
30842237 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
27129230 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
12855817 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
18802055 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
21606371 MGI
involved in cellular response to virus IDA
IDA: Inferred from direct assay
18802055 MGI
acts upstream of or within defense response to virus IMP
IMP: Inferred from mutant phenotype
23770239 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
18562536 MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
12855817 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
27129230 MGI
involved in positive regulation of interferon-alpha production IMP
IMP: Inferred from mutant phenotype
18562536 MGI
involved in positive regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
18562536 MGI
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
30842237 MGI
acts upstream of or within positive regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
17618271 MGI
acts upstream of or within programmed necrotic cell death IMP
IMP: Inferred from mutant phenotype
23770239 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
23160154 MGI
acts upstream of or within regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
28069950 MGI
acts upstream of or within response to bacterium IDA
IDA: Inferred from direct assay
15661922 MGI
acts upstream of or within response to exogenous dsRNA IDA
IDA: Inferred from direct assay
12855817 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
12855817 MGI
acts upstream of or within type I interferon production IGI
IGI: Inferred from genetic interaction
15800576 MGI
involved in type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
27129230 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15661922 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon regulatory factor 3

Recombinant Irf3 Proteins

Cat. No. Product Name Accession Purity
HY-P71747 IRF3 Protein, Mouse (P.pastoris, Myc, His) P70671 (M1-I419) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-176426 Subquinocin 99.83% Phase 4
HY-10249 GSK-690693 99.03% Phase 1

Pre-clinical Phase

Bioactive Molecules (71)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12326A c-di-AMP disodium Agonist 99.14% Unkown
HY-160225 ISD sodium 98.02% Unkown
HY-113469 Cyclic GMP 99.77% Unkown
HY-P1680 Astin C Inhibitor 99.47% Unkown
HY-P1934 Cyclo(Phe-Pro) Inhibitor 99.22% Unkown
HY-101950 KIN1148 Inhibitor 98.0% Unkown
HY-P11072 IRF5-CPP5 Inhibitor 99.23% Unkown
HY-113469A Cyclic GMP sodium 99.89% Unkown
HY-139056 SU0268 Inhibitor 99.96% Unkown
HY-12326B c-di-AMP diammonium Agonist 99.01% Unkown
HY-152956 STING agonist-23 Agonist 99.33% Unkown
HY-W140974 SN-001 Inhibitor 99.22% Unkown
HY-156449 STING-IN-7 Inhibitor 98.29% Unkown
HY-112951 ChX710 99.91% Unkown
HY-123805 KIN1400 98.1% Unkown
HY-D0162 Malachite green hemioxalate 98.0% Unkown
HY-124652 TBK1/IKKε-IN-4 Inhibitor 99.42% Unkown
HY-173425 STING-IN-15 Inhibitor 99.04% Unkown
HY-17663 KMR-206 98.86% Unkown
HY-164278 diABZI-V/C-Mal 99.28% Unkown
HY-12326 c-di-AMP Agonist 99.29% Unkown
HY-152959 STING agonist-26 Agonist 99.56% Unkown
HY-126113 KIN101 99.44% Unkown
HY-168034 diABZI-4 98.33% Unkown
HY-177338 STING agonist-45 Agonist 99.10% Unkown
HY-181526 Sim-9 Inhibitor / Unkown
HY-113469B Cyclic GMP TBAOH / Unkown
HY-W654000 Cyclic GMP-13C,15N2 98.81% Unkown
HY-138646 Poly(deoxyadenylic-thymidylic) acid sodium / Unkown
HY-160222 HSV-60mer sodium 98.11% Unkown
HY-160225F Biotin-labeled ISD sodium / Unkown
HY-162133 MSA-2-Pt / Unkown
HY-173462 TBK1-IN-2 Inhibitor 98.19% Unkown
HY-175714 STING agonist-46 Agonist 98.63% Unkown
HY-176192 SMU-14a Inhibitor / Unkown
HY-178049 UM-259 Inhibitor / Unkown
HY-W767865 Cyclic GMP sodium-13C5 99.03% Unkown
HY-148606 STING modulator-3 Inhibitor / Unkown
HY-148645 STING modulator-4 Modulator / Unkown
HY-152957 STING agonist-24 Agonist / Unkown
HY-152958 STING agonist-25 Agonist / Unkown
HY-152961 STING agonist-28 Agonist / Unkown
HY-158036 PROTAC STING Degrader-2 / Unkown
HY-162844 CDN-3 Activator / Unkown
HY-162963 DN203316 / Unkown
HY-162966 MS7829 Activator / Unkown
HY-162967 MS8588 Degrader / Unkown
HY-173399 hSTING activator-1 / Unkown
HY-174136 STING Degrader-2 / Unkown
HY-174308 ZSA-215 Agonist / Unkown
HY-178047 UM-242 Inhibitor / Unkown
HY-178690 MyD88-IN-4 Inhibitor / Unkown
HY-178915 ITA-5 Inhibitor / Unkown
HY-178916 ITA-9 Inhibitor / Unkown
HY-178951 STING-IN-17 Inhibitor / Unkown
HY-180120 UM-203 / Unkown
HY-180674 LA24 Agonist / Unkown
HY-181484 STING agonist-50 / Unkown
HY-182923 UM-200 Inhibitor / Unkown
HY-183537 KSI-028 Inhibitor / Unkown
HY-183607 SMU-3k / Unkown
HY-184200 Enpp-1-IN-32 / Unkown
HY-N18197 Norkurarinol / Unkown
HY-RS06907 IRF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-149724 Anti-inflammatory agent 65 Inhibitor / Unkown
HY-N10175 Berkeleyacetal C / Unkown
HY-N3548 Catalpalactone Inhibitor / Unkown
HY-N8107 Matairesinol monoglucoside 99.42% Unkown
HY-RS16587 Irf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23022 Irf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W682115 Poly(C) Activator / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991989 MRG004A Antibody 95.44% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irf3 NCBI NCBI:3661