Lrrk2 - leucine-rich repeat kinase 2 Gene

Mus musculus

Also known as Gm927; cI-46; 4921513O20Rik; 9330188B09Rik; D630001M17Rik

Gene ID: 66725 | Gene type: protein coding

About Lrrk2

Chromosome 15: 91,557,378-91,700,323 forward strand.GRCm39:CM001008.3

This gene has 6 transcripts (splice variants), 191 orthologues, 23 paralogues and is associated with 52 phenotypes. Broad expression in kidney adult (RPKM 2.7), lung adult (RPKM 2.3) and 24 other tissues.

Summary

Enables several functions, including beta-catenin destruction complex binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of cellular catabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including Golgi organization; positive regulation of histone deacetylase activity; and protein import into nucleus. Located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum exit site; and mitochondrion. Part of Wnt signalosome and ribonucleoprotein complex. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including autopod; brain; genitourinary system; limb bud; and spinal cord. Used to study Parkinson's disease 8. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and Cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrrk2 Products(1)

mRNA	Protein	Name
NM_025730.3	NP_080006.3	leucine-rich repeat serine/threonine-protein kinase 2

Lrrk2 Protein Structure

LRR_RI

PRK15370

LRR_RI

RocCOR

COR

STKc_LRRK2

0
400
800
1200
1600
2000
2400
2527 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat serine/threonine-protein kinase 2

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112809	GSK2646264	Inhibitor	98.39%	Phase 1

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100411	MLi-2	Inhibitor	99.80%	Unkown
HY-13687	IKK 16	Inhibitor	98.57%	Unkown
HY-10875	LRRK2-IN-1	Inhibitor	99.12%	Unkown
HY-12477	PF-06447475	Inhibitor	99.94%	Unkown
HY-15796	GNE0877	Inhibitor	99.15%	Unkown
HY-148030	XL01126	Inhibitor	99.81%	Unkown
HY-13237	GSK2578215A	Inhibitor	99.78%	Unkown
HY-18163	GNE-7915	Inhibitor	99.82%	Unkown
HY-13488	HG-10-102-01	Inhibitor	99.34%	Unkown
HY-120085	PFE-360	Inhibitor	99.48%	Unkown
HY-15800A	CZC-25146	Inhibitor	99.10%	Unkown
HY-13687A	IKK 16 hydrochloride	Inhibitor	≥98.0%	Unkown
HY-B0792	CZC-54252	Inhibitor	99.38%	Unkown
HY-12282	GNE-9605	Inhibitor	99.72%	Unkown
HY-112855	PF-06454589	Inhibitor	99.73%	Unkown
HY-18163A	GNE-7915 tosylate	Inhibitor	99.69%	Unkown
HY-40294	Indazole	Inhibitor	99.72%	Unkown
HY-142647	EB-42486	Inhibitor	99.62%	Unkown
HY-111493	LRRK2 inhibitor 1	Inhibitor	99.93%	Unkown
HY-152107	LRRK2-IN-7	Inhibitor	98.04%	Unkown
HY-145317	LRRK2-IN-2	Inhibitor	/	Unkown
HY-153058	LRRK2-IN-8	Inhibitor	/	Unkown
HY-145318	LRRK2-IN-3	Inhibitor	/	Unkown
HY-156167	LRRK2-IN-10	Inhibitor	/	Unkown
HY-B0792A	CZC-54252 hydrochloride	Inhibitor	98.44%	Unkown
HY-156429	MK-1468	Inhibitor	/	Unkown
HY-153103	LRRK2/NUAK1/TYK2-IN-1	Inhibitor	/	Unkown
HY-151444	LRRK2-IN-6	Inhibitor	/	Unkown
HY-144074	LRRK2-IN-4	Inhibitor	/	Unkown
HY-163064	CC-3240	Inhibitor	/	Unkown
HY-148353	PF-06455943	Inhibitor	/	Unkown
HY-151441	LRRK2-IN-5	Inhibitor	/	Unkown
HY-152107A	(R,R)-LRRK2-IN-7	Inhibitor	/	Unkown
HY-134562	PF-06371900	Inhibitor	/	Unkown
HY-155150	JH-XII-03-02	Inhibitor	/	Unkown
HY-15800	CZC-25146 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrrk2	NCBI	NCBI:120892

Name
Email *

	Sorry, but the email address you supplied was invalid.