Lrrk2 - leucine-rich repeat kinase 2 Gene

Also Known as Gm927; cI-46; 4921513O20Rik; 9330188B09Rik; D630001M17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66725

About Lrrk2

Chromosome 15: 91,557,378-91,700,323 forward strand.GRCm39:CM001008.3

This gene has 6 transcripts (splice variants), 191 orthologues, 23 paralogues and is associated with 52 phenotypes. Broad expression in kidney adult (RPKM 2.7), lung adult (RPKM 2.3) and 24 other tissues.

Summary

Enables several functions, including beta-catenin destruction complex binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of cellular catabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including Golgi organization; positive regulation of histone deacetylase activity; and protein import into nucleus. Located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum exit site; and mitochondrion. Part of Wnt signalosome and ribonucleoprotein complex. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including autopod; brain; genitourinary system; limb bud; and spinal cord. Used to study Parkinson's disease 8. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and Cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrrk2 Products (1)

mRNA Protein Name
NM_025730.3 NP_080006.3 leucine-rich repeat serine/threonine-protein kinase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin destruction complex binding IPI
IPI: Inferred from physical interaction
22899650 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
21390248 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21048939 MGI
enables protein kinase A binding IPI
IPI: Inferred from physical interaction
24464040 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
24510904 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
27798112 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
27798112 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
21048939 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Golgi organization IGI
IGI: Inferred from genetic interaction
24510904 MGI
involved in endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
25201882 MGI
involved in excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
24464040 MGI
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
24464040 MGI
involved in locomotory exploration behavior IMP
IMP: Inferred from mutant phenotype
24464040 MGI
acts upstream of or within negative regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
26355680 MGI
involved in negative regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
21307259 MGI
acts upstream of or within neuron differentiation IDA
IDA: Inferred from direct assay
26355680 MGI
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
20457918 MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
20457918 MGI
acts upstream of or within protein import into nucleus IDA
IDA: Inferred from direct assay
27798112 MGI
acts upstream of or within protein import into nucleus IMP
IMP: Inferred from mutant phenotype
27798112 MGI
involved in protein localization IMP
IMP: Inferred from mutant phenotype
24464040 MGI
involved in protein localization to endoplasmic reticulum exit site IMP
IMP: Inferred from mutant phenotype
25201882 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
27798112 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
27798112 MGI
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
28720718 MGI
involved in regulation of ER to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
25201882 MGI
involved in regulation of cAMP/PKA signal transduction IMP
IMP: Inferred from mutant phenotype
24464040 MGI
involved in regulation of canonical Wnt signaling pathway IPI
IPI: Inferred from physical interaction
22899650 MGI
involved in regulation of dendritic spine morphogenesis IGI
IGI: Inferred from genetic interaction
24464040 MGI
involved in regulation of dopamine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24464040 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24427314 MGI
involved in regulation of kidney size IMP
IMP: Inferred from mutant phenotype
20457918 MGI
involved in regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
24464040 MGI
involved in regulation of synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
25501810 MGI
involved in regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
25501810 MGI
involved in regulation of synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
21307259 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
17120249 MGI
part of Wnt signalosome IDA
IDA: Inferred from direct assay
22899650 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
27273569 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
17120249 MGI
located in dendrite IDA
IDA: Inferred from direct assay
24464040 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
17120249 MGI
located in endoplasmic reticulum exit site IDA
IDA: Inferred from direct assay
25201882 MGI
located in endosome IDA
IDA: Inferred from direct assay
17120249 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25501810 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25501810 MGI
located in lysosome IDA
IDA: Inferred from direct assay
17120249 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
17341485 MGI
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
17120249 MGI
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
17120249 MGI
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
17120249 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17341485 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
17341485 MGI
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
24427314 MGI
located in synapse IDA
IDA: Inferred from direct assay
22423108 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
17341485 MGI
located in trans-Golgi network IDA
IDA: Inferred from direct assay
17341485 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lrrk2 Protein Structure

LRR_RI

LRR_RI: sd00033 (984 - 1011)

LRR_RI

LRR_RI: sd00033 (1012 - 1035)

PRK15370

PRK15370: cl33128 (1013 - 1289)

LRR_RI

LRR_RI: sd00033 (1036 - 1058)

LRR_RI

LRR_RI: sd00033 (1059 - 1083)

LRR_RI

LRR_RI: sd00033 (1084 - 1107)

LRR_RI

LRR_RI: sd00033 (1108 - 1129)

LRR_RI

LRR_RI: sd00033 (1130 - 1169)

LRR_RI

LRR_RI: sd00033 (1170 - 1196)

LRR_RI

LRR_RI: sd00033 (1197 - 1220)

LRR_RI

LRR_RI: sd00033 (1221 - 1245)

LRR_RI

LRR_RI: sd00033 (1269 - 1290)

RocCOR

RocCOR: cd09914 (1333 - 1506)

COR

COR: cl24610 (1526 - 1739)

STKc_LRRK2

STKc_LRRK2: cd14068 (1883 - 2134)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2400
  • 2527 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat serine/threonine-protein kinase 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112809 GSK2646264 Inhibitor 99.74% Phase 1

Pre-clinical Phase

Bioactive Molecules (65)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100411 MLi-2 Inhibitor 99.80% Unkown
HY-13687 IKK 16 Inhibitor 99.88% Unkown
HY-10875 LRRK2-IN-1 Inhibitor 99.04% Unkown
HY-148030 XL01126 Degrader 98.90% Unkown
HY-40294 Indazole Inhibitor 99.83% Unkown
HY-12477 PF-06447475 Inhibitor 99.94% Unkown
HY-15796 GNE0877 Inhibitor 99.81% Unkown
HY-13237 GSK2578215A Inhibitor 99.82% Unkown
HY-18163 GNE-7915 Inhibitor 99.81% Unkown
HY-13687A IKK 16 hydrochloride Inhibitor 99.95% Unkown
HY-13488 HG-10-102-01 Inhibitor 99.55% Unkown
HY-120085 PFE-360 Inhibitor 99.10% Unkown
HY-P5979 LRRKtide Substrate 99.94% Unkown
HY-15800A CZC-25146 Inhibitor 98.05% Unkown
HY-12282 GNE-9605 Inhibitor 99.51% Unkown
HY-155150 JH-XII-03-02 Degrader 99.33% Unkown
HY-111493 LRRK2 inhibitor 1 Inhibitor 99.80% Unkown
HY-152107 LRRK2-IN-7 Inhibitor 98.03% Unkown
HY-156429 MK-1468 Inhibitor 99.69% Unkown
HY-B0792 CZC-54252 Inhibitor 98.05% Unkown
HY-142647 EB-42486 Inhibitor 99.62% Unkown
HY-163064 CC-3240 Degrader 99.24% Unkown
HY-16936 JH-II-127 Inhibitor 98.0% Unkown
HY-18163A GNE-7915 tosylate Inhibitor 99.06% Unkown
HY-112855 PF-06454589 Inhibitor 99.91% Unkown
HY-W107722 IN04 98.51% Unkown
HY-148353 PF-06455943 Inhibitor 98.21% Unkown
HY-75368 SRI-31255 Inhibitor 99.88% Unkown
HY-174427 RN341 Inhibitor / Unkown
HY-174420 RN277 Inhibitor / Unkown
HY-152107A (R,R)-LRRK2-IN-7 Inhibitor / Unkown
HY-145317 LRRK2-IN-2 Inhibitor / Unkown
HY-145318 LRRK2-IN-3 Inhibitor / Unkown
HY-186110 PROTAC LRRK2 Degrader-5 Degrader / Unkown
HY-180320 Lu AF58786 Inhibitor / Unkown
HY-165543 SRI-29132 Inhibitor / Unkown
HY-153058 LRRK2-IN-8 Inhibitor / Unkown
HY-182928 LRRK2-IN-21 Inhibitor / Unkown
HY-144074 LRRK2-IN-4 Inhibitor / Unkown
HY-153103 LRRK2/NUAK1/TYK2-IN-1 Inhibitor / Unkown
HY-184652 LRRK2/JNK3-IN-1 Inhibitor / Unkown
HY-175651 LRRK2-IN-20 Inhibitor / Unkown
HY-161571 LRRK2-IN-13 Inhibitor / Unkown
HY-134562 PF-06371900 Inhibitor 99.43% Unkown
HY-158365 LRRK2-IN-14 Inhibitor / Unkown
HY-177016 LRRK2-IN-19 Inhibitor / Unkown
HY-168041 LRRK2-IN-15 Inhibitor / Unkown
HY-151444 LRRK2-IN-6 Inhibitor / Unkown
HY-169576 LRRK2-IN-16 Inhibitor / Unkown
HY-161570 LRRK2-IN-12 Inhibitor / Unkown
HY-184198 LRRK2-IN-22 Inhibitor / Unkown
HY-178796 PROTAC LRRK2 Degrader-4 Degrader / Unkown
HY-B0792A CZC-54252 hydrochloride Inhibitor 98.44% Unkown
HY-171801 PROTAC LRRK2 Degrader-1 Degrader / Unkown
HY-151441 LRRK2-IN-5 Inhibitor / Unkown
HY-172952 LRRK2-IN-17 Inhibitor / Unkown
HY-162699 LY2023-001 Inhibitor / Unkown
HY-178797 PROTAC LRRK2 Degrader-3 Degrader / Unkown
HY-156167 LRRK2-IN-10 Inhibitor / Unkown
HY-171802 PROTAC LRRK2 Degrader-2 Degrader / Unkown
HY-181046 Multi-kinase-IN-14 Inhibitor / Unkown
HY-P10636 Nictide / Unkown
HY-169900 FX 2149 Inhibitor / Unkown
HY-15800 CZC-25146 hydrochloride Inhibitor / Unkown
HY-149187 LRRK2-IN-9 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrrk2 NCBI NCBI:120892