Hdac9 - histone deacetylase 9 Gene

Also Known as HD9; HD7B; HDRP; Mitr; Hdac7b; mKIAA0744; D030072B18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 79221

About Hdac9

Chromosome 12: 34,097,579-34,967,094 reverse strand.GRCm39:CM001005.3

This gene has 12 transcripts (splice variants), 235 orthologues, 10 paralogues and is associated with 2 phenotypes. Broad expression in frontal lobe adult (RPKM 2.7), cortex adult (RPKM 1.4) and 21 other tissues.

Summary

Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Acts upstream of or within several processes, including determination of adult lifespan; negative regulation of transcription by RNA polymerase II; and regulation of skeletal muscle fiber development. Part of Histone Methyltransferase complex. Is expressed in several structures, including 2-cell stage embryo; future midbrain; heart; nervous system; and trunk myotome. Orthologous to human HDAC9 (histone deacetylase 9). [provided by Alliance of Genome Resources, Apr 2022]

Hdac9 Products (2)

mRNA Protein Name
NM_001271386.1 NP_001258315.1 histone deacetylase 9 isoform 1
NM_024124.3 NP_077038.2 histone deacetylase 9 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
12242305 MGI
enables histone H3K14 deacetylase activity IMP
IMP: Inferred from mutant phenotype
21708950 MGI
enables histone H3K9 deacetylase activity IMP
IMP: Inferred from mutant phenotype
21708950 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11390982 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
11022042 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA repair IGI
IGI: Inferred from genetic interaction
21746928 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: Inferred from genetic interaction
21746928 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
15367668 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11022042 MGI
involved in negative regulation of gene expression, epigenetic IMP
IMP: Inferred from mutant phenotype
21708950 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11390982 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16280321 MGI
acts upstream of or within regulation of skeletal muscle fiber development IGI
IGI: Inferred from genetic interaction
17786239 MGI
acts upstream of or within regulation of skeletal muscle fiber differentiation IGI
IGI: Inferred from genetic interaction
17786239 MGI
Cellular Component GO Annotation Evidence References Source
part of histone methyltransferase complex IDA
IDA: Inferred from direct assay
12242305 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac9 Protein Structure

ClassIIa_HDAC9_Gln-rich-N

ClassIIa_HDAC9_Gln-rich-N: cd10163 (58 - 147)

HDAC_classIIa

HDAC_classIIa: cd11681 (652 - 1029)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1088 a.a.
Protein Preferred Names Protein Names

histone deacetylase 9

  • MEF2-interacting transcription repressor MITR

  • histone deacetylase 7B

  • histone deacetylase-related protein

Hdac9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Hdac9 Q99N13 Hdac6 Mus musculus Q9Z2V5
Anti Bait CoIP
25873389
Intra
Hdac9 Q99N13 Pcbp1 Mus musculus P60335
Y2H
15102471
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-150109 Purinostat mesylate Inhibitor 99.45% Phase 3
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18361 TMP195 Inhibitor 99.82% Unkown
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-18360 TMP269 Inhibitor 98.16% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-16012A Domatinostat Inhibitor 99.34% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-112719 BRD 4354 Inhibitor 98.10% Unkown
HY-169259 HDAC9-IN-1 Inhibitor 95.13% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-149285 NT160 Inhibitor 99.58% Unkown
HY-112719B BRD 4354 ditrifluoroacetate Inhibitor 98.06% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac9 NCBI NCBI:9734