Hdac5 - histone deacetylase 5 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84580

About Hdac5

Primary_assembly 10: 87,152,978-87,188,235 reverse strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 194 orthologues, 12 paralogues and is associated with 13 phenotypes. Biased expression in Heart (RPKM 189.9), Brain (RPKM 149.1) and 9 other tissues.

Summary

Enables chromatin binding activity. Involved in several processes, including cellular response to lipopolysaccharide; response to activity; and response to cocaine. Located in cytoplasm and nucleus. Part of protein-containing complex. Biomarker of acute kidney failure; mental depression; middle cerebral artery infarction; and pulmonary hypertension. Orthologous to human HDAC5 (histone deacetylase 5). [provided by Alliance of Genome Resources, Apr 2022]

Hdac5 Products (1)

mRNA Protein Name
NM_053450.1 NP_445902.1 histone deacetylase 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
19638401 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
22933299 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
12850547 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
21198979 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
21954104 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
16767219 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12896970 RGD
located in nucleus IDA
IDA: Inferred from direct assay
12896970 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
22360269 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac5 Protein Structure

ClassIIa_HDAC_Gln-rich-N

ClassIIa_HDAC_Gln-rich-N: cl25407 (86 - 173)

Arginase_HDAC

Arginase_HDAC: cl17011 (688 - 1104)

  • 0
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  • 1000
  • 1120 a.a.
Protein Preferred Names Protein Names

histone deacetylase 5

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-150109 Purinostat mesylate Inhibitor 99.45% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-13432 Nanatinostat Inhibitor 99.67% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (46)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18361 TMP195 Inhibitor 99.82% Unkown
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-18360 TMP269 Inhibitor 98.16% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-16012A Domatinostat Inhibitor 99.34% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-112719 BRD 4354 Inhibitor 98.10% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-149285 NT160 Inhibitor 99.58% Unkown
HY-143248 KR-39038 Inhibitor 99.68% Unkown
HY-181126 G194-0712 Activator 99.82% Unkown
HY-112719B BRD 4354 ditrifluoroacetate Inhibitor 98.06% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-P10462A SAP15 acetate Inhibitor 98.04% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-179019 HDAC-IN-94 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-13432A Nanatinostat TFA Inhibitor / Unkown
HY-181579 HDAC6-IN-74 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-176733 HDAC6-IN-61 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-P10462 SAP15 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-184574 HDAC-IN-104 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac5 NCBI NCBI:10014