2. Gene
  3. Hdac5 - histone deacetylase 5 Gene

Hdac5 - histone deacetylase 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 84580 | Gene type: protein coding

About Hdac5

Primary_assembly 10: 87,152,978-87,188,235 reverse strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 194 orthologues, 12 paralogues and is associated with 13 phenotypes. Biased expression in Heart (RPKM 189.9), Brain (RPKM 149.1) and 9 other tissues.

Summary

Enables chromatin binding activity. Involved in several processes, including cellular response to lipopolysaccharide; response to activity; and response to cocaine. Located in cytoplasm and nucleus. Part of protein-containing complex. Biomarker of acute kidney failure; mental depression; middle cerebral artery infarction; and pulmonary hypertension. Orthologous to human HDAC5 (histone deacetylase 5). [provided by Alliance of Genome Resources, Apr 2022]

Hdac5 Products(1)

mRNA Protein Name
NM_053450.1 NP_445902.1 histone deacetylase 5

Hdac5 Protein Structure

ClassIIa_HDAC_Gln-rich-N

ClassIIa_HDAC_Gln-rich-N: cl25407 (86 - 173)

Arginase_HDAC

Arginase_HDAC: cl17011 (688 - 1104)

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  • 1120 a.a.
Protein Preferred Names Protein Names

histone deacetylase 5

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13322 Pracinostat Inhibitor 99.82% Yes
Clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842 Givinostat Inhibitor 98.05% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 99.19% Phase 1
Pre-clinical Phase
Bioactive Molecules (26)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18361 TMP195 Inhibitor 99.57% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-18360 TMP269 Inhibitor 98.05% Unkown
HY-13428 Tubacin Inhibitor 95.50% Unkown
HY-16699 Nexturastat A Inhibitor 99.03% Unkown
HY-112719 BRD 4354 Inhibitor 99.66% Unkown
HY-115475 SW-100 Inhibitor 99.59% Unkown
HY-119939 CHDI-390576 Inhibitor 98.07% Unkown
HY-143248 KR-39038 Inhibitor 99.48% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-149285 NT160 Inhibitor 99.58% Unkown
HY-112719B BRD 4354 ditrifluoroacetate Inhibitor 98.06% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-150109 Purinostat mesylate Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-149208 HDAC-IN-53 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac5 NCBI NCBI:10014