9-Hydroxyoctadecanoic acid
Based on 2 publication(s) in Google Scholar
9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that inhibits ∼66.4% HDAC1 enzymatic activity at 5 μM. 9-Hydroxyoctadecanoic acid shows anticancer activity.
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- 純度: 98.0%
- CAS 番号: 3384-24-5
- 分子式: C18H36O3
- 分子量:300.48
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 9-Hydroxyoctadecanoic acid
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生物活性
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HDAC1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>30 μM
Compound: 7
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Inhibition of CRM1 interaction with HIV1 HA-tagged Rev in HeLa cells assessed as inhibition of Rev nuclear export by indirect fluorescent antibody technique
Inhibition of CRM1 interaction with HIV1 HA-tagged Rev in HeLa cells assessed as inhibition of Rev nuclear export by indirect fluorescent antibody technique
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[PMID: 20176483] |
9-Hydroxyoctadecanoic acid (9-HSA) can bind to the active site of the three-dimensional model of the human HDAC1 protein[1].
9-Hydroxyoctadecanoic acid (9-HSA) (100 μM; 24 h) inhibits HT29 cell proliferation, induces arrest in G0/G1, and increases p21WAF1 expression both at the transcriptional and the translational levels[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT29 cell
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Concentration:100 μM
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Incubation Time:24 h
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Result:Resulted in a significant inhibition of cell proliferation.
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Cell Line:HT29 cell
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Concentration:100 μM
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Incubation Time:24 h
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Result:Decreased S-phase activity by 50.2% compared with untreated controls, and the growth inhibition was associated with a strong arrest in G0/G1.
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Cell Line:HT29 cell
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Concentration:100 μM
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Incubation Time:24 h
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Result:Increased the expression of p21WAF1.
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Cell Line:HT29 cell
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Concentration:100 μM
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Incubation Time:24 h
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Result:Induced p21WAF1 tanscript.
化学情報
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CAS 番号 3384-24-5
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性状 Solid
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分子量 300.48
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分子式 C18H36O3
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Color White to off-white
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SMILES
O=C(CCCCCCCC(CCCCCCCCC)O)O
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別名
9-Hydroxystearic acid; 9-HSA
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Cancer Cell
Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer. [Abstract]2024 Oct 14;42(10):1729-1746.e8. PMID: 39303724 -
Cell Host Microbe
Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections. [Abstract]2026 Feb 11;34(2):245-262.e8. PMID: 41605216
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (332.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
[1]. Calonghi N, et al. Histone deacetylase 1: a target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancer. J Lipid Res. 2005 Aug;46(8):1596-603. [Content Brief]
[2]. Calonghi N, et al. 9-Hydroxystearic acid upregulates p21(WAF1) in HT29 cancer cells. Biochem Biophys Res Commun. 2004 Jan 30;314(1):138-42. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3280 mL | 16.6400 mL | 33.2801 mL | 83.2002 mL |
| 5 mM | 0.6656 mL | 3.3280 mL | 6.6560 mL | 16.6400 mL | |
| 10 mM | 0.3328 mL | 1.6640 mL | 3.3280 mL | 8.3200 mL | |
| 15 mM | 0.2219 mL | 1.1093 mL | 2.2187 mL | 5.5467 mL | |
| 20 mM | 0.1664 mL | 0.8320 mL | 1.6640 mL | 4.1600 mL | |
| 25 mM | 0.1331 mL | 0.6656 mL | 1.3312 mL | 3.3280 mL | |
| 30 mM | 0.1109 mL | 0.5547 mL | 1.1093 mL | 2.7733 mL | |
| 40 mM | 0.0832 mL | 0.4160 mL | 0.8320 mL | 2.0800 mL | |
| 50 mM | 0.0666 mL | 0.3328 mL | 0.6656 mL | 1.6640 mL | |
| 60 mM | 0.0555 mL | 0.2773 mL | 0.5547 mL | 1.3867 mL | |
| 80 mM | 0.0416 mL | 0.2080 mL | 0.4160 mL | 1.0400 mL | |
| 100 mM | 0.0333 mL | 0.1664 mL | 0.3328 mL | 0.8320 mL |
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