製品番号: HY-B0956

パロモマイシン硫酸塩

(別名: Paromomycin (sulfate); Aminosidine (sulfate))

4 Cited Publications

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.96%
CAS 番号: 1263-89-4
分子式: C₂₃H₄₇N₅O₁₈S
分子量:713.71

保管条件:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Paromomycin sulfate 構造式

CAS 番号: 1263-89-4

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
- 臨床実験
化学情報
Publications (4)
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

Aminoglycoside

Amebae

Antibiotic アイソフォーム固有の製品をすべて表示 :

Parasite アイソフォーム固有の製品をすべて表示 :

体外実験

Paromomycin sulfate (500 μg/ml) reduces intracellular parasitic forms by 97.2% compared to control in Caco-2 cells and reduces the percentage of intracellular C. parvum forms by 99.5% in HCT-8 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Paromomycin sulfate (oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection) reduces the number of oocyst per gram of feces and intestine. It shows minimal focal inflammation in only 20% of the sections at 50 mg/kg from the intestines of mice infected with C. parvum and only 10% of focal inflammation at 200 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Swiss albino mice^[1]
Dosage:

50 mg/kg-200 mg/kg
Administration:

Oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection
Result:

Was against cryptosporidiosis in vivo.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 1263-89-4
性状 Solid
分子量 713.71
分子式 C₂₃H₄₇N₅O₁₈S
Color White to off-white
SMILES

N[C@@H](C[C@H]1N)[C@@]([C@@H]([C@H]1O)O[C@@](O[C@H](CO)[C@H]2O[C@@]([C@@H]([C@@H](O)[C@@H]3O)N)([H])O[C@H]3CN)([H])[C@@H]2O)([H])O[C@H]([C@@H]([C@@H](O)[C@@H]4O)N)O[C@@H]4CO.O=S(O)(O)=O
別名

Paromomycin (sulfate); Aminosidine (sulfate)
Structure Classification
- Antibiotics
- Other Antibiotics
- Antibiotics
- Plant Cell Culture
- Antibiotics
- Mammalian Cell Culture
- Antibiotics
- Resistance Selection
Initial Source
- Microorganisms
Streptomyces rimosus NRRL 2455
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (4)

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Journal Impact Factor

Int J Mol Sci

Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation. [Abstract]

2025 Feb 6;26(3):1381. PMID: 39941149
Comput Biol Chem

Targeting quorum sensing in Pseudomonas aeruginosa with high-affinity inhibitors: A high-throughput screening and in-silico analysis. [Abstract]

2025 Aug:117:108419. PMID: 40088808
Acta Trop

Paromomycin-loaded mannosylated chitosan nanoparticles: Synthesis, characterization and targeted drug delivery against leishmaniasis. [Abstract]

2019 Sep:197:105045. PMID: 31158341
Vet Res Commun

Biological characterization of lipoic acid- and heme-dependent Escherichia coli small colony variants isolated from sheep in Xinjiang, China. [Abstract]

2024 Dec;48(6):3859-3872. PMID: 39325108

溶剤 & 溶解度

体外:

H₂O : 100 mg/mL (140.11 mM; ultrasonic and warming and heat to 80°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Ethanol : < 1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.4011 mL

7.0056 mL

14.0113 mL

5 mM

0.2802 mL

1.4011 mL

2.8023 mL

10 mM

0.1401 mL

0.7006 mL

1.4011 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (140.11 mM); Clear solution; Need ultrasonic

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (282 KB)
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- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Tony J Tavares, et al. Structure of the cytosine-cytosine mismatch in the thymidylate synthase mRNA binding site and analysis of its interaction with the aminoglycoside paromomycin. RNA. 2009 May;15(5):911-22. [Content Brief]

[2]. Mohamed Mammeri, et al. Efficacy of chitosan, a natural polysaccharide, against Cryptosporidium parvum in vitro and in vivo in neonatal mice. Exp Parasitol. 2018 Nov;194:1-8. [Content Brief]

[3]. Ibrahim Aly, et al. Efficacy of Low and High Dose of Paromomycin Sulfate for Treatment of Cryptosporidiosis in Immunosuppressed Infected-Mice.Global Veterinaria 15 (2): 137-143, 2015

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.4011 mL	7.0056 mL	14.0113 mL	35.0282 mL
	5 mM	0.2802 mL	1.4011 mL	2.8023 mL	7.0056 mL
	10 mM	0.1401 mL	0.7006 mL	1.4011 mL	3.5028 mL
	15 mM	0.0934 mL	0.4670 mL	0.9341 mL	2.3352 mL
	20 mM	0.0701 mL	0.3503 mL	0.7006 mL	1.7514 mL
	25 mM	0.0560 mL	0.2802 mL	0.5605 mL	1.4011 mL
	30 mM	0.0467 mL	0.2335 mL	0.4670 mL	1.1676 mL
	40 mM	0.0350 mL	0.1751 mL	0.3503 mL	0.8757 mL
	50 mM	0.0280 mL	0.1401 mL	0.2802 mL	0.7006 mL
	60 mM	0.0234 mL	0.1168 mL	0.2335 mL	0.5838 mL
	80 mM	0.0175 mL	0.0876 mL	0.1751 mL	0.4379 mL
	100 mM	0.0140 mL	0.0701 mL	0.1401 mL	0.3503 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Paromomycin sulfate

4 Cited Publications

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パロモマイシン 硫酸塩

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MedChemExpress（MCE）の使用を引用している文献 Paromomycin sulfate

Antibiotic アイソフォーム固有の製品をすべて表示

Parasite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (4)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Paromomycin sulfate 関連分類

HY-B0956 関連分類

パロモマイシン硫酸塩