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製品番号: HY-123238

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AG-024104

Name: AG-024104
Brand: MedChemExpress
SKU: HY-123238
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AG-024104 is a CDK inhibitor with K_i values of 2.3 nM (CDK1/cyclinB), 1.8 nM (CDK2/cyclinA), and 0.67 nM (CDK4/cyclinD). AG-024104 functionally inhibits kinase activity of CDK1/cyclinB, CDK2/cyclinA, and CDK4/cyclinD. AG-024104 serves as a negative control for peripheral leukocyte toxicity studies in preclinical development.

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CAS 番号: 750575-23-6
分子式: C₂₄H₂₈F₂N₆O₄S₂
分子量:566.64

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

AG-024104 構造式

CAS 番号: 750575-23-6

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生物活性
- 製品説明
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
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生物活性

製品説明

CDK アイソフォーム固有の製品をすべて表示 :

体外実験

AG-024104 potently inhibits purified CDK1/cyclinB, CDK2/cyclinA, and CDK4/cyclinD enzymes with K_i values of 2.3 nM, 1.8 nM, and 0.67 nM, respectively^[1].
AG-024104 (4 days) inhibits HCT-116 colorectal carcinoma cell growth with an IC₅₀ of 51 nM^[1].
AG-024104 (24 h) induces cytotoxicity in human PBMCs and monkey PBLs with TC₅₀ values of 7.2 μM and 4.0 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HCT-116 colorectal carcinoma cells
Concentration:

concentrations to achieve 50% growth inhibition (IC₅₀ determination)
Incubation Time:

4 days
Result:

Inhibited HCT-116 cell growth with an IC₅₀ of 51 nM.

Parmacokinetics

Species	Dose	Route	AUC_0-24	T_1/2
Rat^[1]	10 mg/kg	i.v.	2.7 μg·h/mL	1.4 h

体内実験

AG-024104 (10 mg/kg; i.v.; single bolus injection over 2-3 min) does not induce significant acute suppression of peripheral white blood cell counts in male Sprague Dawley rats, with counts remaining at ~93% of pre-treatment levels 24 hours post-dose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (male, ~10 weeks old)^[1]
Dosage:

10 mg/kg
Administration:

i.v.; single bolus injection over 2-3 min
Result:

Remained at ~93% of pre-treatment levels 24 hours post-dose.

化学情報

CAS 番号 750575-23-6
分子量 566.64
分子式 C₂₄H₂₈F₂N₆O₄S₂
SMILES

O=C(C=1SC(=NC1N)NC2CCN(CC2)S(=O)(=O)C3=CN=C(OCCN(C)C)C=C3)C=4C(F)=CC=CC4F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Jessen BA, et al. Peripheral white blood cell toxicity induced by broad spectrum cyclin-dependent kinase inhibitors. J Appl Toxicol. 2007;27(2):133-142. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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生物活性
- 製品説明
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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AG-024104

CDK アイソフォーム固有の製品をすべて表示